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      string(82) "Olympics, postponement to 2021: the reactions of Nolano, Dell’Aquila and Alessio"
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      string(693) "The IOC’s decision to postpone the Tokyo 2020 Games to next year is fully shared by the Italy of taekwondo which even sees an advantage in this extension: “More time to better prepare for the qualifications” Four days have passed since the deliberate and shared decision by the premier of Japan, Abe, and the head ... Read more"
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The IOC’s decision to postpone the Tokyo 2020 Games to next year is fully shared by the Italy of taekwondo which even sees an advantage in this extension: “More time to better prepare for the qualifications”

Four days have passed since the deliberate and shared decision by the premier of Japan, Abe, and the head of the IOC, Bach, to postpone the Tokyo 2020 Olympics to 2021. And if for the athletes it may have been a bitter morsel to to digest, however, everyone believes it was a choice of common sense and great responsibility. Even the blue taekwondo fully agrees with the postponement, Fita had already previously decided to cancel all the competitions scheduled until May, but certainly there are many doubts regarding the future and especially regarding the Olympic qualification tournament, scheduled from 17 to April 19 in Milan and then canceled, which would have delivered the last passes for the Games. Vito Dell’Aquila, first blue qualified in Tokyo 2020 directly through ranking, but also Simone Alessio, World Champion in the middle of the Olympic race, and Claudio Nolano, technical director of the National team, have expressed their opinion.

OF THE EAGLE

“Participating in the Olympics has always been my dream, ever since I was a child – writes Vito Dell’Aquila in a post published on facebook -. Since 2017 I have been traveling around the world participating in about fifteen races a year to win useful ranking points. to qualification. Unfortunately this year no one would have ever expected that a cursed virus would invade the entire planet, causing the death of thousands of people. So I believe that postponing the Games is the most mature and intelligent decision “. The dream of a lifetime was two steps away, but according to the -58 kg European Champion this postponement can only help: “I agree with the decision because it safeguards the health of athletes, technicians and all professionals. convinced that an athlete, however motivated he may be, cannot train to the fullest of his abilities indoors and without the main tools of his specific sport. So I am really happy that the choice was to move the Games to next year and not to keep them this summer or to cancel them, because we will have plenty of time to assimilate what is happening to our planet, train seriously and serenely and be as competitive as possible. so that this ugly phenomenon goes away as soon as possible “.

ALESSIO

Simone Alessio also shares the decision taken by the IOC: “I think that at this moment it is not right to force something that goes against public health. The Olympics are, in addition to the dream of every athlete, a sport party and it is right that there is the best environment around it “. For those who, like the -74 kg World Champion, qualification for Tokyo 2020 were still at stake, it can even be an advantage: “As far as I’m concerned, there will be more time to train and consolidate the balance found in the new category. of -80 kg, so as to get to the best qualifications and still be able to hope to conquer the Olympic dream “.

NOLANO

From the point of view of the technical director Claudio Nolano, the strength of an athlete also lies in respecting the rules of the game and therefore in adapting better to today’s emergency situation with a serene look towards the future: “Nobody could have foreseen this situation. athlete cannot set a goal in front of him thinking of not running into some inconvenience, on the contrary the champion focuses them and surpasses them. The postponement of the Olympics affects us all without distinction, we must be respectful of the decisions taken, and I do not hide nice for the image that a sportsman must have. For us specifically I think it is even a situation from which the taekwondo Italy can benefit. We started to work in a more programmed way a few months before Vito’s qualification through ranking and by Antonino Bossolo for para taekwondo and this type of work should have led us to the qualifying tournament in Milan. we were running, tight with the times, and in the case of the women’s team we even had injuries to manage, so the postponement gives us more time to better prepare for qualification. In this sense, however, a discourse relating to the blue choices also reopens: my policy has always been one that all athletes are called into question and have opportunities. Obviously, people with a deep experience and background give more confidence in the face of an important qualification like the Olympic one, but all the more so now all the boys must feel called into question. The only thing that remains to be understood is in terms of the qualification criteria: I don’t think they will change, but in any case we can only respect the decisions that will be made. We all have the commitment to prepare well as soon as we have the chance. I just hope that the boys do not lose the desire and the desire to get involved, this situation of distance from the tatami is a double-edged sword, but we will have to be good at keeping this fire alive now and when we return to the gym “.

We would like to thank the writer of this short article for this incredible web content

Olympics, postponement to 2021: the reactions of Nolano, Dell’Aquila and Alessio

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The IOC’s decision to postpone the Tokyo 2020 Games to next year is fully shared by the Italy of taekwondo which even sees an advantage in this extension: “More time to better prepare for the qualifications”

Four days have passed since the deliberate and shared decision by the premier of Japan, Abe, and the head of the IOC, Bach, to postpone the Tokyo 2020 Olympics to 2021. And if for the athletes it may have been a bitter morsel to to digest, however, everyone believes it was a choice of common sense and great responsibility. Even the blue taekwondo fully agrees with the postponement, Fita had already previously decided to cancel all the competitions scheduled until May, but certainly there are many doubts regarding the future and especially regarding the Olympic qualification tournament, scheduled from 17 to April 19 in Milan and then canceled, which would have delivered the last passes for the Games. Vito Dell’Aquila, first blue qualified in Tokyo 2020 directly through ranking, but also Simone Alessio, World Champion in the middle of the Olympic race, and Claudio Nolano, technical director of the National team, have expressed their opinion.

OF THE EAGLE

“Participating in the Olympics has always been my dream, ever since I was a child – writes Vito Dell’Aquila in a post published on facebook -. Since 2017 I have been traveling around the world participating in about fifteen races a year to win useful ranking points. to qualification. Unfortunately this year no one would have ever expected that a cursed virus would invade the entire planet, causing the death of thousands of people. So I believe that postponing the Games is the most mature and intelligent decision “. The dream of a lifetime was two steps away, but according to the -58 kg European Champion this postponement can only help: “I agree with the decision because it safeguards the health of athletes, technicians and all professionals. convinced that an athlete, however motivated he may be, cannot train to the fullest of his abilities indoors and without the main tools of his specific sport. So I am really happy that the choice was to move the Games to next year and not to keep them this summer or to cancel them, because we will have plenty of time to assimilate what is happening to our planet, train seriously and serenely and be as competitive as possible. so that this ugly phenomenon goes away as soon as possible “.

ALESSIO

Simone Alessio also shares the decision taken by the IOC: “I think that at this moment it is not right to force something that goes against public health. The Olympics are, in addition to the dream of every athlete, a sport party and it is right that there is the best environment around it “. For those who, like the -74 kg World Champion, qualification for Tokyo 2020 were still at stake, it can even be an advantage: “As far as I’m concerned, there will be more time to train and consolidate the balance found in the new category. of -80 kg, so as to get to the best qualifications and still be able to hope to conquer the Olympic dream “.

NOLANO

From the point of view of the technical director Claudio Nolano, the strength of an athlete also lies in respecting the rules of the game and therefore in adapting better to today’s emergency situation with a serene look towards the future: “Nobody could have foreseen this situation. athlete cannot set a goal in front of him thinking of not running into some inconvenience, on the contrary the champion focuses them and surpasses them. The postponement of the Olympics affects us all without distinction, we must be respectful of the decisions taken, and I do not hide nice for the image that a sportsman must have. For us specifically I think it is even a situation from which the taekwondo Italy can benefit. We started to work in a more programmed way a few months before Vito’s qualification through ranking and by Antonino Bossolo for para taekwondo and this type of work should have led us to the qualifying tournament in Milan. we were running, tight with the times, and in the case of the women’s team we even had injuries to manage, so the postponement gives us more time to better prepare for qualification. In this sense, however, a discourse relating to the blue choices also reopens: my policy has always been one that all athletes are called into question and have opportunities. Obviously, people with a deep experience and background give more confidence in the face of an important qualification like the Olympic one, but all the more so now all the boys must feel called into question. The only thing that remains to be understood is in terms of the qualification criteria: I don’t think they will change, but in any case we can only respect the decisions that will be made. We all have the commitment to prepare well as soon as we have the chance. I just hope that the boys do not lose the desire and the desire to get involved, this situation of distance from the tatami is a double-edged sword, but we will have to be good at keeping this fire alive now and when we return to the gym “.

We would like to thank the writer of this short article for this incredible web content

Olympics, postponement to 2021: the reactions of Nolano, Dell’Aquila and Alessio

" ["date_timestamp"]=> int(1640652619) } [1]=> array(11) { ["title"]=> string(114) "Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’" ["link"]=> string(151) "https://redhatbeauty.com/healthandscience/clues-to-treatment-of-schizophrenia-and-bipolar-disorder-found-in-recently-evolved-region-of-the-dark-genome/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Tue, 28 Dec 2021 00:20:57 +0000" ["category"]=> string(83) "Health And SciencebipolarcluesDarkdisorderevolvedgenomeregionschizophreniatreatment" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3459" ["description"]=> string(792) "Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’ – NovLink Home Mash H Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’ We want to say thanks to the author of this post for this outstanding web content ... Read more" ["content"]=> array(1) { ["encoded"]=> string(6737) "




Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’ – NovLink














We want to say thanks to the author of this post for this outstanding web content

Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’

" } ["summary"]=> string(792) "Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’ – NovLink Home Mash H Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’ We want to say thanks to the author of this post for this outstanding web content ... Read more" ["atom_content"]=> string(6737) "




Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’ – NovLink














We want to say thanks to the author of this post for this outstanding web content

Clues to treatment of schizophrenia and bipolar disorder found in recently evolved region of the ‘dark genome’

" ["date_timestamp"]=> int(1640650857) } [2]=> array(11) { ["title"]=> string(70) "Dietary fiber improves outcomes for melanoma patients on immunotherapy" ["link"]=> string(113) "https://redhatbeauty.com/healthandscience/dietary-fiber-improves-outcomes-for-melanoma-patients-on-immunotherapy/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Mon, 27 Dec 2021 22:53:09 +0000" ["category"]=> string(75) "Health And ScienceDietaryfiberimmunotherapyimprovesmelanomaoutcomespatients" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3457" ["description"]=> string(712) "Journal Reference: Christine N. Spencer, Jennifer L. McQuade, Vancheswaran Gopalakrishnan, John A. McCulloch, Marie Vetizou, Alexandria P. Cogdill, Md A. Wadud Khan, Xiaotao Zhang, Michael G. White, Christine B. Peterson, Matthew C. Wong, Golnaz Morad, Theresa Rodgers, Jonathan H. Badger, Beth A. Helmink, Miles C. Andrews, Richard R. Rodrigues, Andrey Morgun, Young S. Kim, Jason ... Read more" ["content"]=> array(1) { ["encoded"]=> string(7365) "

Journal Reference:

  1. Christine N. Spencer, Jennifer L. McQuade, Vancheswaran Gopalakrishnan, John A. McCulloch, Marie Vetizou, Alexandria P. Cogdill, Md A. Wadud Khan, Xiaotao Zhang, Michael G. White, Christine B. Peterson, Matthew C. Wong, Golnaz Morad, Theresa Rodgers, Jonathan H. Badger, Beth A. Helmink, Miles C. Andrews, Richard R. Rodrigues, Andrey Morgun, Young S. Kim, Jason Roszik, Kristi L. Hoffman, Jiali Zheng, Yifan Zhou, Yusra B. Medik, Laura M. Kahn, Sarah Johnson, Courtney W. Hudgens, Khalida Wani, Pierre-Olivier Gaudreau, Angela L. Harris, Mohamed A. Jamal, Erez N. Baruch, Eva Perez-Guijarro, Chi-Ping Day, Glenn Merlino, Barbara Pazdrak, Brooke S. Lochmann, Robert A. Szczepaniak-Sloane, Reetakshi Arora, Jaime Anderson, Chrystia M. Zobniw, Eliza Posada, Elizabeth Sirmans, Julie Simon, Lauren E. Haydu, Elizabeth M. Burton, Linghua Wang, Minghao Dang, Karen Clise-Dwyer, Sarah Schneider, Thomas Chapman, Nana-Ama A. S. Anang, Sheila Duncan, Joseph Toker, Jared C. Malke, Isabella C. Glitza, Rodabe N. Amaria, Hussein A. Tawbi, Adi Diab, Michael K. Wong, Sapna P. Patel, Scott E. Woodman, Michael A. Davies, Merrick I. Ross, Jeffrey E. Gershenwald, Jeffrey E. Lee, Patrick Hwu, Vanessa Jensen, Yardena Samuels, Ravid Straussman, Nadim J. Ajami, Kelly C. Nelson, Luigi Nezi, Joseph F. Petrosino, P. Andrew Futreal, Alexander J. Lazar, Jianhua Hu, Robert R. Jenq, Michael T. Tetzlaff, Yan Yan, Wendy S. Garrett, Curtis Huttenhower, Padmanee Sharma, Stephanie S. Watowich, James P. Allison, Lorenzo Cohen, Giorgio Trinchieri, Carrie R. Daniel, Jennifer A. Wargo. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science, 2021; 374 (6575): 1632 DOI: 10.1126/science.aaz7015

Published today in Science, the study led by the University of Texas and the National Institutes of Health is a promising development in the fight against multiple types of cancer including melanoma, the most deadly form of skin cancer, the researchers said.

Nationwide, melanoma is the fifth-most common cancer. Roughly 100,000 new melanoma cases will be diagnosed in the United States in the coming year, and more than 7,000 of those patients are expected to die, according to the American Cancer Society.

One of the most aggressive cancers, melanoma kills by metastasizing, or spreading, to other organs such as the liver, lungs and brain.

The new study focuses on a therapeutic technique called immune checkpoint blockade, often referred to by its initials of ICB, which has revolutionized treatment of melanoma, and cancer in general.

ICB therapy relies on inhibitor drugs that block proteins called checkpoints that are produced by certain immune system cells — T cells, for example — and also by some cancer cells.

Checkpoints help prevent immune responses from being too strong, but sometimes that means keeping T cells from killing cancer cells. Thus, when the checkpoints are blocked, T cells can do a better job of killing cancer cells.

“ICB has been a game-changer in cancer therapy, and the influence of the gut microbiome on therapeutic response has been demonstrated in numerous studies, in preclinical models and also in research involving human cohorts,” Morgun said. “A person’s microbiome is shaped by a wide range of environmental factors including food and medications, while human genetics accounts for a much smaller proportion of the microbiome variation from person to person.”

The human gut microbiome is a complicated community of more than 10 trillion microbial cells from about 1,000 different bacterial species. It has remained unclear whether dietary fiber intake and the use of commercially available probiotics affect immunotherapy response in cancer patients, Morgun said.

Morgun and collaborators on this study looked at hundreds of melanoma patients, analyzing their gut microbiomes, dietary habits, use of probiotics, disease features and treatment outcomes. Most of the patients were being treated via ICB, typically a type known as anti-programmed cell death protein therapy, abbreviated to anti-PD-1.

A parallel study involving mice implanted with tumors was also part of the research.

In the human, observational cohort portion of the study, higher dietary fiber intake was associated with disease non-progression among patients on ICB; the most pronounced benefits were found in patients with strong dietary fiber intake and no probiotic use.

The mouse model generated similar results.

“We showed that dietary fiber and probiotic use, both known to impact the gut microbiome, are associated with differing ICB outcomes,” Morgun said. “From the human cohort results we can’t assign causality — there may have been other things going on with those patients that we didn’t measure in this study.”

But Morgun said the results in the mice support the idea that anti-tumor immunity is strongest with a high-fiber diet and no probiotics.

To help make sense of microbiome complexity, Morgun and Natalia Shulzhenko of Oregon State’s Carlson College of Veterinary Medicine earlier invented a computer modeling technique known as transkingdom network analysis.

The model, used in this latest work, integrates multiple types of “omics” data — metagenomic, metabolomic, lipidomic, proteomic, etc. — in determining how interactions among specific types of gut microbes help or hinder biological functions in the host. In this case, the microbial interactions involved how well the host responds to immune checkpoint blockade.

It’s important to note, Morgun said, that transkingdom network analysis in mice showed a family of bacteria, Ruminococcaceae, among the organisms increased by the high-fiber diet; the same bacteria were found in the current study involving humans and in previous, related research with people.

Double-blind, randomized dietary intervention studies will be critical for establishing whether a targeted, achievable diet change at the start of ICB therapy can improve patient outcomes, he said.

“And though the findings suggest that some commercially available probiotics may be harmful for patients on ICB, more research is needed to determine which probiotics could actually be beneficial,” Morgun said.

Leading the study were Jennifer Wargo, Lorenzo Cohen and Carrie Daniel of the University of Texas and Giorgio Trinchieri of the National Institutes of Health. Approximately 80 scientists took part in the research.

Funders included the NIH and the U.S. Department of State.

We would love to give thanks to the writer of this short article for this remarkable web content

Dietary fiber improves outcomes for melanoma patients on immunotherapy

" } ["summary"]=> string(712) "Journal Reference: Christine N. Spencer, Jennifer L. McQuade, Vancheswaran Gopalakrishnan, John A. McCulloch, Marie Vetizou, Alexandria P. Cogdill, Md A. Wadud Khan, Xiaotao Zhang, Michael G. White, Christine B. Peterson, Matthew C. Wong, Golnaz Morad, Theresa Rodgers, Jonathan H. Badger, Beth A. Helmink, Miles C. Andrews, Richard R. Rodrigues, Andrey Morgun, Young S. Kim, Jason ... Read more" ["atom_content"]=> string(7365) "

Journal Reference:

  1. Christine N. Spencer, Jennifer L. McQuade, Vancheswaran Gopalakrishnan, John A. McCulloch, Marie Vetizou, Alexandria P. Cogdill, Md A. Wadud Khan, Xiaotao Zhang, Michael G. White, Christine B. Peterson, Matthew C. Wong, Golnaz Morad, Theresa Rodgers, Jonathan H. Badger, Beth A. Helmink, Miles C. Andrews, Richard R. Rodrigues, Andrey Morgun, Young S. Kim, Jason Roszik, Kristi L. Hoffman, Jiali Zheng, Yifan Zhou, Yusra B. Medik, Laura M. Kahn, Sarah Johnson, Courtney W. Hudgens, Khalida Wani, Pierre-Olivier Gaudreau, Angela L. Harris, Mohamed A. Jamal, Erez N. Baruch, Eva Perez-Guijarro, Chi-Ping Day, Glenn Merlino, Barbara Pazdrak, Brooke S. Lochmann, Robert A. Szczepaniak-Sloane, Reetakshi Arora, Jaime Anderson, Chrystia M. Zobniw, Eliza Posada, Elizabeth Sirmans, Julie Simon, Lauren E. Haydu, Elizabeth M. Burton, Linghua Wang, Minghao Dang, Karen Clise-Dwyer, Sarah Schneider, Thomas Chapman, Nana-Ama A. S. Anang, Sheila Duncan, Joseph Toker, Jared C. Malke, Isabella C. Glitza, Rodabe N. Amaria, Hussein A. Tawbi, Adi Diab, Michael K. Wong, Sapna P. Patel, Scott E. Woodman, Michael A. Davies, Merrick I. Ross, Jeffrey E. Gershenwald, Jeffrey E. Lee, Patrick Hwu, Vanessa Jensen, Yardena Samuels, Ravid Straussman, Nadim J. Ajami, Kelly C. Nelson, Luigi Nezi, Joseph F. Petrosino, P. Andrew Futreal, Alexander J. Lazar, Jianhua Hu, Robert R. Jenq, Michael T. Tetzlaff, Yan Yan, Wendy S. Garrett, Curtis Huttenhower, Padmanee Sharma, Stephanie S. Watowich, James P. Allison, Lorenzo Cohen, Giorgio Trinchieri, Carrie R. Daniel, Jennifer A. Wargo. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science, 2021; 374 (6575): 1632 DOI: 10.1126/science.aaz7015

Published today in Science, the study led by the University of Texas and the National Institutes of Health is a promising development in the fight against multiple types of cancer including melanoma, the most deadly form of skin cancer, the researchers said.

Nationwide, melanoma is the fifth-most common cancer. Roughly 100,000 new melanoma cases will be diagnosed in the United States in the coming year, and more than 7,000 of those patients are expected to die, according to the American Cancer Society.

One of the most aggressive cancers, melanoma kills by metastasizing, or spreading, to other organs such as the liver, lungs and brain.

The new study focuses on a therapeutic technique called immune checkpoint blockade, often referred to by its initials of ICB, which has revolutionized treatment of melanoma, and cancer in general.

ICB therapy relies on inhibitor drugs that block proteins called checkpoints that are produced by certain immune system cells — T cells, for example — and also by some cancer cells.

Checkpoints help prevent immune responses from being too strong, but sometimes that means keeping T cells from killing cancer cells. Thus, when the checkpoints are blocked, T cells can do a better job of killing cancer cells.

“ICB has been a game-changer in cancer therapy, and the influence of the gut microbiome on therapeutic response has been demonstrated in numerous studies, in preclinical models and also in research involving human cohorts,” Morgun said. “A person’s microbiome is shaped by a wide range of environmental factors including food and medications, while human genetics accounts for a much smaller proportion of the microbiome variation from person to person.”

The human gut microbiome is a complicated community of more than 10 trillion microbial cells from about 1,000 different bacterial species. It has remained unclear whether dietary fiber intake and the use of commercially available probiotics affect immunotherapy response in cancer patients, Morgun said.

Morgun and collaborators on this study looked at hundreds of melanoma patients, analyzing their gut microbiomes, dietary habits, use of probiotics, disease features and treatment outcomes. Most of the patients were being treated via ICB, typically a type known as anti-programmed cell death protein therapy, abbreviated to anti-PD-1.

A parallel study involving mice implanted with tumors was also part of the research.

In the human, observational cohort portion of the study, higher dietary fiber intake was associated with disease non-progression among patients on ICB; the most pronounced benefits were found in patients with strong dietary fiber intake and no probiotic use.

The mouse model generated similar results.

“We showed that dietary fiber and probiotic use, both known to impact the gut microbiome, are associated with differing ICB outcomes,” Morgun said. “From the human cohort results we can’t assign causality — there may have been other things going on with those patients that we didn’t measure in this study.”

But Morgun said the results in the mice support the idea that anti-tumor immunity is strongest with a high-fiber diet and no probiotics.

To help make sense of microbiome complexity, Morgun and Natalia Shulzhenko of Oregon State’s Carlson College of Veterinary Medicine earlier invented a computer modeling technique known as transkingdom network analysis.

The model, used in this latest work, integrates multiple types of “omics” data — metagenomic, metabolomic, lipidomic, proteomic, etc. — in determining how interactions among specific types of gut microbes help or hinder biological functions in the host. In this case, the microbial interactions involved how well the host responds to immune checkpoint blockade.

It’s important to note, Morgun said, that transkingdom network analysis in mice showed a family of bacteria, Ruminococcaceae, among the organisms increased by the high-fiber diet; the same bacteria were found in the current study involving humans and in previous, related research with people.

Double-blind, randomized dietary intervention studies will be critical for establishing whether a targeted, achievable diet change at the start of ICB therapy can improve patient outcomes, he said.

“And though the findings suggest that some commercially available probiotics may be harmful for patients on ICB, more research is needed to determine which probiotics could actually be beneficial,” Morgun said.

Leading the study were Jennifer Wargo, Lorenzo Cohen and Carrie Daniel of the University of Texas and Giorgio Trinchieri of the National Institutes of Health. Approximately 80 scientists took part in the research.

Funders included the NIH and the U.S. Department of State.

We would love to give thanks to the writer of this short article for this remarkable web content

Dietary fiber improves outcomes for melanoma patients on immunotherapy

" ["date_timestamp"]=> int(1640645589) } [3]=> array(11) { ["title"]=> string(84) "CBD reduces glioblastoma’s dimension, supportive environment in experimental model" ["link"]=> string(123) "https://redhatbeauty.com/healthandscience/cbd-reduces-glioblastomas-dimension-supportive-environment-in-experimental-model/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Mon, 27 Dec 2021 21:35:14 +0000" ["category"]=> string(88) "Health And ScienceCBDdimensionenvironmentExperimentalglioblastomasmodelreducessupportive" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3455" ["description"]=> string(786) "Journal Reference: Hesam Khodadadi, Évila Lopes Salles, Ahmet Alptekin, Daniel Mehrabian, Martin Rutkowski, Ali S. Arbab, W. Andrew Yeudall, Jack C. Yu, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani, Babak Baban. Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment. Cannabis and Cannabinoid Research, 2021; DOI: 10.1089/can.2021.0098 “We saw a ... Read more" ["content"]=> array(1) { ["encoded"]=> string(9747) "

Journal Reference:

  1. Hesam Khodadadi, Évila Lopes Salles, Ahmet Alptekin, Daniel Mehrabian, Martin Rutkowski, Ali S. Arbab, W. Andrew Yeudall, Jack C. Yu, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani, Babak Baban. Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment. Cannabis and Cannabinoid Research, 2021; DOI: 10.1089/can.2021.0098

“We saw a significant reduction in the size of the tumor and its microenvironment was different,” Dr. Babak Baban, immunologist and associate dean for research at the Dental College of Georgia at Augusta University says, after only seven days of treatment.

Researchers at DCG and the Medical College of Georgia say that the inhaler approach not only helped ensure the compound found in cannabis reached the brain, but that the method of delivery could, much like asthma inhalers, eventually be easily used by patients.

It was the first study to use CBD in an animal model of glioblastoma, they report in the journal Cannabis and Cannabinoid Research.

Using modified glioblastoma cells from humans, they created what is called an orthotopic glioblastoma model, to provide the most realistic model they could for this most common and lethal malignant brain tumor. By day eight the aggressive tumor was established in the brain of the mice, and at day 9 they started giving daily doses of inhaled CBD or a placebo that continued for seven days. They then looked again at an image of the tumor and directly at the tumor tissue.

While the approach is likely easily applicable to humans, at this juncture they are looking primarily at the biological response of the tumor to CBD, says Dr. Martin Rutkowski, MCG neurosurgeon whose expertise includes operating on these patients who tend to present after a seizure or sudden loss of consciousness, or with slower onset of neurological deficits like a weak arm, vision or cognitive problems.

“It’s probably one of the most aggressive cancers period. We are in desperate need of research and more treatments,” the neurosurgeon and study coauthor says. “What we have right now is not working very well,” he says.

“Family members will bring patients in and say they are just not thinking right, that their memory is all over the place, or that they got fired from their job because they are no longer doing things right that they have been doing for 30 years,” Rutkowski says.

Today’s treatment includes surgery, followed by chemotherapy and radiation therapy. “Surgery does not offer a cure but it does offer an important first step in maximizing quality of life and prognosis,” Rutkowski says, noting there is a clear relationship between the amount of tumor that can be removed surgically and the length of survival.

They found that CBD appears adept at altering the tumor’s ecosystem, or supportive tumor microenvironment, including restoring levels of inflammation that target rather than protect the glioblastoma, which could make it a safe, effective and novel adjunct therapy for these patients.

“It is about immune balance,” says Baban, corresponding author. Inflammation is heightened in response to a frontline attack on a tumor, which is a normal response; in fact our immune system is regularly attacking cancerous or precancerous cells. But when a tumor manages to become established, the tumor takes charge, switching to producing a state of more chronic inflammation that ultimately protects it from the immune system, he says.

The tumor microenvironment established by the cancer cells, includes things like immune cells as well as blood vessels and growth factors to enable more blood vessel growth, which is key to tumor growth and survival, enabling it to thrive where it starts and to spread.

For a glioblastoma, the tumor microenvironment has been shown to have increased activity of natural immune checkpoints, which as their name implies, helps prevent an overzealous immune response that could hurt the body, like what happens in autoimmune diseases like rheumatoid arthritis. But in this case the damping down means protecting the tumor. There also is a notably small presence of cytotoxic T cells, which are particularly adept at putting a tumor or other invader in the crosshairs.

CBD was able to improve the immune mix against the tumor including reducing the tumor’s coopting of glial cells — a brain cell type that normally protects neurons, including producing inflammation to fight invaders — into instead becoming a major component of the tumor, now called a glioblastoma associated macrophage, which helps support and protect it.

It also suppressed the protein P-selectin, which typically plays a role in important functions like injury repair, and one of the things it recruits to help is platelets. However in cancer, P-selectin helps tumors spread and be treatment resistant, in fact it’s a focus for new cancer treatments. Like many other inhabitants of the microenvironment, there is some evidence one way P-selectin works for tumors is by also serving as an immune checkpoint.

Apelin, a pervasive enzyme made by a lot of different cell types, is normally present at low levels in the brain. But in glioblastoma its expression is much higher, the researchers say, and it supports critical blood vessel growth, in addition to promoting the cancer stem cells thought to birth the tumor as well as being key to the tumor’s resistance to treatment. There also is evidence that apelin functions as an immune checkpoint in the tumor microenvironment, and others have shown that inhibiting apelin, which CBD does, decreases the growth rate of the deadly brain tumor.

CBD also suppresses IL-8, which macrophages normally release to promote inflammation and aid injury repair, and which recruits other immune cells in the process. But glioblastoma also secretes IL-8 to help promote cell migration and angiogenesis and its level has been shown to be high in many cancers, including glioblastoma. In fact, these fast-growing tumors are good at growing blood vessels, which in turn support their growth, and drugs that target this specific skill have been shown to help.

CBD also reduces other key immune checkpoints, like the enzyme indoleamine 2,3 dioxygenase, or IDO, another localized blockade to the immune response that tumors are known to use.

CBD also improved the mix by increasing expression of some good things, like CD103, a complex thought to help the immune system recognize cancer, and that is generally associated with a better cancer prognosis, as well as CD8, a sugar-coated protein that also aids an immune response. There is evidence suppressing immune checkpoints, which CBD does, drives levels of both up.

“It is a puzzle and that is why we need good immune regulators,” Baban says. “CBD is a very smart regulator,” that can make adjustments based on its environment, like turning apelin down in glioblastoma and up in the face of lungs damaged by COVID, he says. DCG and MCG investigators reported last year that CBD actually increases levels of apelin, which they have shown go way down with a SARS-CoV-2 infection, and in that scenario the apelin increase reduces inflammation and the “cytokine storm” that has wreaked destruction in the lungs of patients.

“Right now we are excited that the tumor shrinks,” Baban says of the cannabinoid’s impact in glioblastoma. He and Rutkowski note that the positive results from inhaled CBD occurred without being done in tandem with other therapies, like surgery. They anticipate if CBD is eventually used for these patients, it will be a novel adjunct to these therapies.

Next steps include seeing how long the positive changes last and looking further at the impact on cancer stem cells. They also want to assess CBD’s impact on the high recurrence rates of glioblastoma. They have more evidence for hope: In an earlier study they incubated the tumor cells in CBD before implantation, and no tumors resulted, Baban says.

The latest significant advance in treating glioblastoma came more than 15 years ago, with the addition of the chemotherapy drug temozolamide to radiation, which extended survival about one and one half months and was celebrated by patients and caregivers alike, Rutkowski says.

CBD’s skill at controlling inflammation, and their research experience with other conditions where inflammation is key, including Alzheimer’s, led Baban and his colleagues to pursue the cannabis derivative for glioblastoma. Other researchers are looking at CBD in combination with other cannabis derivatives, including THC, but because CBD is such an interactive compound, including with other active compounds in cannabis, like THC, the DCG and MCG researchers thought it would be more effective alone.

We would like to say thanks to the writer of this article for this outstanding content

CBD reduces glioblastoma’s dimension, supportive environment in experimental model

" } ["summary"]=> string(786) "Journal Reference: Hesam Khodadadi, Évila Lopes Salles, Ahmet Alptekin, Daniel Mehrabian, Martin Rutkowski, Ali S. Arbab, W. Andrew Yeudall, Jack C. Yu, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani, Babak Baban. Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment. Cannabis and Cannabinoid Research, 2021; DOI: 10.1089/can.2021.0098 “We saw a ... Read more" ["atom_content"]=> string(9747) "

Journal Reference:

  1. Hesam Khodadadi, Évila Lopes Salles, Ahmet Alptekin, Daniel Mehrabian, Martin Rutkowski, Ali S. Arbab, W. Andrew Yeudall, Jack C. Yu, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani, Babak Baban. Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment. Cannabis and Cannabinoid Research, 2021; DOI: 10.1089/can.2021.0098

“We saw a significant reduction in the size of the tumor and its microenvironment was different,” Dr. Babak Baban, immunologist and associate dean for research at the Dental College of Georgia at Augusta University says, after only seven days of treatment.

Researchers at DCG and the Medical College of Georgia say that the inhaler approach not only helped ensure the compound found in cannabis reached the brain, but that the method of delivery could, much like asthma inhalers, eventually be easily used by patients.

It was the first study to use CBD in an animal model of glioblastoma, they report in the journal Cannabis and Cannabinoid Research.

Using modified glioblastoma cells from humans, they created what is called an orthotopic glioblastoma model, to provide the most realistic model they could for this most common and lethal malignant brain tumor. By day eight the aggressive tumor was established in the brain of the mice, and at day 9 they started giving daily doses of inhaled CBD or a placebo that continued for seven days. They then looked again at an image of the tumor and directly at the tumor tissue.

While the approach is likely easily applicable to humans, at this juncture they are looking primarily at the biological response of the tumor to CBD, says Dr. Martin Rutkowski, MCG neurosurgeon whose expertise includes operating on these patients who tend to present after a seizure or sudden loss of consciousness, or with slower onset of neurological deficits like a weak arm, vision or cognitive problems.

“It’s probably one of the most aggressive cancers period. We are in desperate need of research and more treatments,” the neurosurgeon and study coauthor says. “What we have right now is not working very well,” he says.

“Family members will bring patients in and say they are just not thinking right, that their memory is all over the place, or that they got fired from their job because they are no longer doing things right that they have been doing for 30 years,” Rutkowski says.

Today’s treatment includes surgery, followed by chemotherapy and radiation therapy. “Surgery does not offer a cure but it does offer an important first step in maximizing quality of life and prognosis,” Rutkowski says, noting there is a clear relationship between the amount of tumor that can be removed surgically and the length of survival.

They found that CBD appears adept at altering the tumor’s ecosystem, or supportive tumor microenvironment, including restoring levels of inflammation that target rather than protect the glioblastoma, which could make it a safe, effective and novel adjunct therapy for these patients.

“It is about immune balance,” says Baban, corresponding author. Inflammation is heightened in response to a frontline attack on a tumor, which is a normal response; in fact our immune system is regularly attacking cancerous or precancerous cells. But when a tumor manages to become established, the tumor takes charge, switching to producing a state of more chronic inflammation that ultimately protects it from the immune system, he says.

The tumor microenvironment established by the cancer cells, includes things like immune cells as well as blood vessels and growth factors to enable more blood vessel growth, which is key to tumor growth and survival, enabling it to thrive where it starts and to spread.

For a glioblastoma, the tumor microenvironment has been shown to have increased activity of natural immune checkpoints, which as their name implies, helps prevent an overzealous immune response that could hurt the body, like what happens in autoimmune diseases like rheumatoid arthritis. But in this case the damping down means protecting the tumor. There also is a notably small presence of cytotoxic T cells, which are particularly adept at putting a tumor or other invader in the crosshairs.

CBD was able to improve the immune mix against the tumor including reducing the tumor’s coopting of glial cells — a brain cell type that normally protects neurons, including producing inflammation to fight invaders — into instead becoming a major component of the tumor, now called a glioblastoma associated macrophage, which helps support and protect it.

It also suppressed the protein P-selectin, which typically plays a role in important functions like injury repair, and one of the things it recruits to help is platelets. However in cancer, P-selectin helps tumors spread and be treatment resistant, in fact it’s a focus for new cancer treatments. Like many other inhabitants of the microenvironment, there is some evidence one way P-selectin works for tumors is by also serving as an immune checkpoint.

Apelin, a pervasive enzyme made by a lot of different cell types, is normally present at low levels in the brain. But in glioblastoma its expression is much higher, the researchers say, and it supports critical blood vessel growth, in addition to promoting the cancer stem cells thought to birth the tumor as well as being key to the tumor’s resistance to treatment. There also is evidence that apelin functions as an immune checkpoint in the tumor microenvironment, and others have shown that inhibiting apelin, which CBD does, decreases the growth rate of the deadly brain tumor.

CBD also suppresses IL-8, which macrophages normally release to promote inflammation and aid injury repair, and which recruits other immune cells in the process. But glioblastoma also secretes IL-8 to help promote cell migration and angiogenesis and its level has been shown to be high in many cancers, including glioblastoma. In fact, these fast-growing tumors are good at growing blood vessels, which in turn support their growth, and drugs that target this specific skill have been shown to help.

CBD also reduces other key immune checkpoints, like the enzyme indoleamine 2,3 dioxygenase, or IDO, another localized blockade to the immune response that tumors are known to use.

CBD also improved the mix by increasing expression of some good things, like CD103, a complex thought to help the immune system recognize cancer, and that is generally associated with a better cancer prognosis, as well as CD8, a sugar-coated protein that also aids an immune response. There is evidence suppressing immune checkpoints, which CBD does, drives levels of both up.

“It is a puzzle and that is why we need good immune regulators,” Baban says. “CBD is a very smart regulator,” that can make adjustments based on its environment, like turning apelin down in glioblastoma and up in the face of lungs damaged by COVID, he says. DCG and MCG investigators reported last year that CBD actually increases levels of apelin, which they have shown go way down with a SARS-CoV-2 infection, and in that scenario the apelin increase reduces inflammation and the “cytokine storm” that has wreaked destruction in the lungs of patients.

“Right now we are excited that the tumor shrinks,” Baban says of the cannabinoid’s impact in glioblastoma. He and Rutkowski note that the positive results from inhaled CBD occurred without being done in tandem with other therapies, like surgery. They anticipate if CBD is eventually used for these patients, it will be a novel adjunct to these therapies.

Next steps include seeing how long the positive changes last and looking further at the impact on cancer stem cells. They also want to assess CBD’s impact on the high recurrence rates of glioblastoma. They have more evidence for hope: In an earlier study they incubated the tumor cells in CBD before implantation, and no tumors resulted, Baban says.

The latest significant advance in treating glioblastoma came more than 15 years ago, with the addition of the chemotherapy drug temozolamide to radiation, which extended survival about one and one half months and was celebrated by patients and caregivers alike, Rutkowski says.

CBD’s skill at controlling inflammation, and their research experience with other conditions where inflammation is key, including Alzheimer’s, led Baban and his colleagues to pursue the cannabis derivative for glioblastoma. Other researchers are looking at CBD in combination with other cannabis derivatives, including THC, but because CBD is such an interactive compound, including with other active compounds in cannabis, like THC, the DCG and MCG researchers thought it would be more effective alone.

We would like to say thanks to the writer of this article for this outstanding content

CBD reduces glioblastoma’s dimension, supportive environment in experimental model

" ["date_timestamp"]=> int(1640640914) } [4]=> array(11) { ["title"]=> string(77) "Westbrook warns the Lakers: “Just do what they ask me: now I play my way”" ["link"]=> string(99) "https://redhatbeauty.com/nba/westbrook-warns-the-lakers-just-do-what-they-ask-me-now-i-play-my-way/" ["dc"]=> array(1) { ["creator"]=> string(10) "Holly June" } ["pubdate"]=> string(31) "Mon, 27 Dec 2021 21:23:33 +0000" ["category"]=> string(27) "NBALakersplaywarnsWestbrook" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3452" ["description"]=> string(643) "Russ still can’t fit into a troubled team: “They all have ideas about what I should do on the pitch, but now I’ll take care of it” Not working. Russell Westbrook was supposed to be the third star of the Lakers, but it is one of the many problems of a team that, playing to ... Read more" ["content"]=> array(1) { ["encoded"]=> string(5105) "

Russ still can’t fit into a troubled team: “They all have ideas about what I should do on the pitch, but now I’ll take care of it”

Not working. Russell Westbrook was supposed to be the third star of the Lakers, but it is one of the many problems of a team that, playing to win the title, has passed Christmas with 16 wins and 18 losses and an open streak of 5 defeats. Russ is in the eye of the storm: for the 19.6 points per game he puts on the scoresheet, never so few since his second season in the NBA, and for what appears to be a chronic inability to play alongside LeBron. “Everyone tells me to be myself, to play like Russ, but no one really knows what it means – said Westbrook after training on Monday -: from now on I have my way”.

Being Westbrook

A proclamation that sounds almost like a threat to the Lakers. The problems are also of the game: Westbrook has not yet integrated into the schemes of coach Vogel, still firm for Covid, so much so that the relationship with the coach is not idyllic. The 33-year-old often looks like a fish out of water: he goes twice as fast as his teammates, so much so that when he launches into those counterattacks that have made him lucky, he often finds himself alone, forced to close down at a time when the shot is not entering. “When it happens, you can only go on – he says -: my game does not revolve around the ball that enters the basket or not, but in all the things I do to help the team win. My mentality is to go forward and always try to improve “. When the Lakers took him via trade from Washington, coach Vogel imagined Westbrook as the team’s metronome: the one who dictates the pace, the one who alternates with LeBron in the construction of the game, the one who helps him improve his teammates. None of this has happened: also thanks to the many injuries and the constant line-up changes, Russ still doesn’t seem to have dropped into the part.

the turning point

Westbrook, who shot 4/20 from the field at Christmas against the Nets, decided it was time for a change. “Everyone has an idea of ​​what I should do, they tell me what they think and how they would like me to be on the pitch,” he said. I just want to play and think about doing what I do best, what I can do to help the team: get the c … on the pitch, trying to improve my teammates as I have been doing for years. People expect me to put in 25 points, 15 rebounds and 15 assists every night, but that’s not normal. I know I’ve done this in the last few years, but it’s not normal. They all say to let Russ be Russ, but nobody but me really knows what it means to be Russ: from now on, I am only interested in doing what I know I can do, regardless of what others think I should do ”.

Group

Westbrook’s loneliness is evident, despite the words. In the summer, in the dinner at James’ house with LeBron and Anthony Davis that laid the foundations for his move to the Lakers, he had promised to change for the good of the team, to work to integrate himself into a system in which he is no longer the North Star. but one of the columns, in which more than shining with its own light it must understand how to make its light reflect on others. Two months into the season, Westbrook still hasn’t figured out how to be a Laker: “We don’t want to leave him alone in this, but we want him to be himself,” says David Fizdale, coach Vogel’s substitute. He is criticized a lot, but he is doing the things he has to do: the assists, the offensive rebounds, the commitment he puts us in defense. We have to understand together what to do, how to help him: but it all starts with him playing like a real Russ ”. The problem for the Lakers, though, is that Westbrook and the team seem to have different ideas about what it’s like to play as a real Russ.

We would love to thank the writer of this short article for this remarkable material

Westbrook warns the Lakers: “Just do what they ask me: now I play my way”

" } ["summary"]=> string(643) "Russ still can’t fit into a troubled team: “They all have ideas about what I should do on the pitch, but now I’ll take care of it” Not working. Russell Westbrook was supposed to be the third star of the Lakers, but it is one of the many problems of a team that, playing to ... Read more" ["atom_content"]=> string(5105) "

Russ still can’t fit into a troubled team: “They all have ideas about what I should do on the pitch, but now I’ll take care of it”

Not working. Russell Westbrook was supposed to be the third star of the Lakers, but it is one of the many problems of a team that, playing to win the title, has passed Christmas with 16 wins and 18 losses and an open streak of 5 defeats. Russ is in the eye of the storm: for the 19.6 points per game he puts on the scoresheet, never so few since his second season in the NBA, and for what appears to be a chronic inability to play alongside LeBron. “Everyone tells me to be myself, to play like Russ, but no one really knows what it means – said Westbrook after training on Monday -: from now on I have my way”.

Being Westbrook

A proclamation that sounds almost like a threat to the Lakers. The problems are also of the game: Westbrook has not yet integrated into the schemes of coach Vogel, still firm for Covid, so much so that the relationship with the coach is not idyllic. The 33-year-old often looks like a fish out of water: he goes twice as fast as his teammates, so much so that when he launches into those counterattacks that have made him lucky, he often finds himself alone, forced to close down at a time when the shot is not entering. “When it happens, you can only go on – he says -: my game does not revolve around the ball that enters the basket or not, but in all the things I do to help the team win. My mentality is to go forward and always try to improve “. When the Lakers took him via trade from Washington, coach Vogel imagined Westbrook as the team’s metronome: the one who dictates the pace, the one who alternates with LeBron in the construction of the game, the one who helps him improve his teammates. None of this has happened: also thanks to the many injuries and the constant line-up changes, Russ still doesn’t seem to have dropped into the part.

the turning point

Westbrook, who shot 4/20 from the field at Christmas against the Nets, decided it was time for a change. “Everyone has an idea of ​​what I should do, they tell me what they think and how they would like me to be on the pitch,” he said. I just want to play and think about doing what I do best, what I can do to help the team: get the c … on the pitch, trying to improve my teammates as I have been doing for years. People expect me to put in 25 points, 15 rebounds and 15 assists every night, but that’s not normal. I know I’ve done this in the last few years, but it’s not normal. They all say to let Russ be Russ, but nobody but me really knows what it means to be Russ: from now on, I am only interested in doing what I know I can do, regardless of what others think I should do ”.

Group

Westbrook’s loneliness is evident, despite the words. In the summer, in the dinner at James’ house with LeBron and Anthony Davis that laid the foundations for his move to the Lakers, he had promised to change for the good of the team, to work to integrate himself into a system in which he is no longer the North Star. but one of the columns, in which more than shining with its own light it must understand how to make its light reflect on others. Two months into the season, Westbrook still hasn’t figured out how to be a Laker: “We don’t want to leave him alone in this, but we want him to be himself,” says David Fizdale, coach Vogel’s substitute. He is criticized a lot, but he is doing the things he has to do: the assists, the offensive rebounds, the commitment he puts us in defense. We have to understand together what to do, how to help him: but it all starts with him playing like a real Russ ”. The problem for the Lakers, though, is that Westbrook and the team seem to have different ideas about what it’s like to play as a real Russ.

We would love to thank the writer of this short article for this remarkable material

Westbrook warns the Lakers: “Just do what they ask me: now I play my way”

" ["date_timestamp"]=> int(1640640213) } [5]=> array(11) { ["title"]=> string(61) "Vaccine obligation? Thus the super green pass comes to sport" ["link"]=> string(96) "https://redhatbeauty.com/volleyball/vaccine-obligation-thus-the-super-green-pass-comes-to-sport/" ["dc"]=> array(1) { ["creator"]=> string(12) "Sally Scully" } ["pubdate"]=> string(31) "Mon, 27 Dec 2021 20:41:35 +0000" ["category"]=> string(46) "VolleyBallgreenobligationpasssportsupervaccine" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3449" ["description"]=> string(629) "Decree and doubts: for basketball and volleyball, unless there are exceptions, the buffer is no longer enough. And also for outdoor sports … A decree and several “sporting” questions that have not yet been answered. The first sums them all up a bit: the adoption of the reinforced green pass or super green pass, ie ... Read more" ["content"]=> array(1) { ["encoded"]=> string(4845) "

Decree and doubts: for basketball and volleyball, unless there are exceptions, the buffer is no longer enough. And also for outdoor sports …

A decree and several “sporting” questions that have not yet been answered. The first sums them all up a bit: the adoption of the reinforced green pass or super green pass, ie reserved only for vaccinated with at least two doses and cured but not simply “buffered”, actually means a vaccination obligation for sports at closed and also indirectly for outdoor disciplines that still need gyms and changing rooms? The question is already on the table in an interview between the Ministry of Health and the Sports Department. In fact, there is time until January 10, the day of the entry into force of this part of the provisions, to unravel the tangle of question marks.

Complicated waivers

But let’s try to tidy up. First point: in the press release from the Sports office there is talk of a reinforced green pass for “gyms, swimming pools, team sports” limited to “indoor activities”. Therefore, basketball, volleyball and handball would be included, with their entire chain of championships, but also individual disciplines, certainly those of contact. It is necessary to understand if the top management will be able to take advantage of an exemption, as has occurred several times in recent months with the famous exception for the preparation for events of national or international interest, a fabric with decidedly rather large meshes that allowed the continuation of activities for thousands of members for a large period. Reproposing the derogation seems difficult also because in this case the vast majority of top athletes are vaccinated, and even for some time. In the world of professional sports, and therefore of basketball but not volleyball, a possible interpretative solution is emerging: athletes are workers in all respects, and this condition equates them to those who still have the right to enter with a tampon. But even this reading is considered rather tiring because the mask is always used in the workplace and the distance can be respected. Is football? Like other outdoor disciplines, it is not directly involved. However, a professional team (and not only) uses gyms and changing rooms in their daily lives: at that point what to do? In super organized societies, individual indoor areas could even be envisaged to avoid contact. But it is complicated.

Avoid the worst

However, the growth of the epidemiological curve is a fact that must be considered. Let’s face it: the anti Covid Christmas decree, compared to the premises, has spared much more impactful measures towards the world of football and sport in general. The idea of ​​asking for the negative swab also from those who are vaccinated (or who is vaccinated with only two doses) has been frozen for the moment. In fact, there is only the obligation to wear an FFP2 mask as regards the presence of the public (the roofs of 75 percent outdoors and 60 percent indoors were not touched). The super green pass is basically a way to remove closures or generalized reductions in activities, in short, to avoid the worst.

Instructors don’t

Of course, there is the decision that concerns the basic user. Here the need for a reinforced green pass, for indoor activities, is made explicit by the law decree. Even if it will not extend, a point of balance would have been reached on this, to the range of instructors, technicians and masters. However, even in this case the guidelines should try to make the set of measures as coherent as possible. As always, to decide, even more than the law, will be its “translation”.

We want to say thanks to the author of this short article for this outstanding web content

Vaccine obligation? Thus the super green pass comes to sport

" } ["summary"]=> string(629) "Decree and doubts: for basketball and volleyball, unless there are exceptions, the buffer is no longer enough. And also for outdoor sports … A decree and several “sporting” questions that have not yet been answered. The first sums them all up a bit: the adoption of the reinforced green pass or super green pass, ie ... Read more" ["atom_content"]=> string(4845) "

Decree and doubts: for basketball and volleyball, unless there are exceptions, the buffer is no longer enough. And also for outdoor sports …

A decree and several “sporting” questions that have not yet been answered. The first sums them all up a bit: the adoption of the reinforced green pass or super green pass, ie reserved only for vaccinated with at least two doses and cured but not simply “buffered”, actually means a vaccination obligation for sports at closed and also indirectly for outdoor disciplines that still need gyms and changing rooms? The question is already on the table in an interview between the Ministry of Health and the Sports Department. In fact, there is time until January 10, the day of the entry into force of this part of the provisions, to unravel the tangle of question marks.

Complicated waivers

But let’s try to tidy up. First point: in the press release from the Sports office there is talk of a reinforced green pass for “gyms, swimming pools, team sports” limited to “indoor activities”. Therefore, basketball, volleyball and handball would be included, with their entire chain of championships, but also individual disciplines, certainly those of contact. It is necessary to understand if the top management will be able to take advantage of an exemption, as has occurred several times in recent months with the famous exception for the preparation for events of national or international interest, a fabric with decidedly rather large meshes that allowed the continuation of activities for thousands of members for a large period. Reproposing the derogation seems difficult also because in this case the vast majority of top athletes are vaccinated, and even for some time. In the world of professional sports, and therefore of basketball but not volleyball, a possible interpretative solution is emerging: athletes are workers in all respects, and this condition equates them to those who still have the right to enter with a tampon. But even this reading is considered rather tiring because the mask is always used in the workplace and the distance can be respected. Is football? Like other outdoor disciplines, it is not directly involved. However, a professional team (and not only) uses gyms and changing rooms in their daily lives: at that point what to do? In super organized societies, individual indoor areas could even be envisaged to avoid contact. But it is complicated.

Avoid the worst

However, the growth of the epidemiological curve is a fact that must be considered. Let’s face it: the anti Covid Christmas decree, compared to the premises, has spared much more impactful measures towards the world of football and sport in general. The idea of ​​asking for the negative swab also from those who are vaccinated (or who is vaccinated with only two doses) has been frozen for the moment. In fact, there is only the obligation to wear an FFP2 mask as regards the presence of the public (the roofs of 75 percent outdoors and 60 percent indoors were not touched). The super green pass is basically a way to remove closures or generalized reductions in activities, in short, to avoid the worst.

Instructors don’t

Of course, there is the decision that concerns the basic user. Here the need for a reinforced green pass, for indoor activities, is made explicit by the law decree. Even if it will not extend, a point of balance would have been reached on this, to the range of instructors, technicians and masters. However, even in this case the guidelines should try to make the set of measures as coherent as possible. As always, to decide, even more than the law, will be its “translation”.

We want to say thanks to the author of this short article for this outstanding web content

Vaccine obligation? Thus the super green pass comes to sport

" ["date_timestamp"]=> int(1640637695) } [6]=> array(11) { ["title"]=> string(90) "Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects" ["link"]=> string(132) "https://redhatbeauty.com/healthandscience/fingers-made-of-laser-gentle-controlled-grabbing-and-rotation-of-biological-micro-objects/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Mon, 27 Dec 2021 20:18:15 +0000" ["category"]=> string(84) "Health And SciencebiologicalcontrolledFingersgentlegrabbinglasermicroobjectsrotation" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3447" ["description"]=> string(749) "Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects – NovLink Home Mash D Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects We wish to give thanks to the author of this short article for this remarkable material Fingers made of laser gentle: Controlled grabbing and rotation of ... Read more" ["content"]=> array(1) { ["encoded"]=> string(6513) "




Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects – NovLink














We wish to give thanks to the author of this short article for this remarkable material

Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects

" } ["summary"]=> string(749) "Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects – NovLink Home Mash D Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects We wish to give thanks to the author of this short article for this remarkable material Fingers made of laser gentle: Controlled grabbing and rotation of ... Read more" ["atom_content"]=> string(6513) "




Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects – NovLink














We wish to give thanks to the author of this short article for this remarkable material

Fingers made of laser gentle: Controlled grabbing and rotation of biological micro-objects

" ["date_timestamp"]=> int(1640636295) } [7]=> array(11) { ["title"]=> string(78) "Italy, Lamaro almost captain. All Blacks, who before: “It would be crazy”" ["link"]=> string(99) "https://redhatbeauty.com/rugby/italy-lamaro-almost-captain-all-blacks-who-before-it-would-be-crazy/" ["dc"]=> array(1) { ["creator"]=> string(10) "Lance Kind" } ["pubdate"]=> string(31) "Mon, 27 Dec 2021 20:03:26 +0000" ["category"]=> string(34) "RugbyBlackscaptaincrazyItalyLamaro" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3444" ["description"]=> string(670) "Coach Crowley, from the match on November 6, could entrust the ranks to the 23-year-old Roman flanker: “But I would remain the same as always” By dint of hearing it, the prophecy is becoming a reality. After all, Michele Lamaro was born a captain. Since July, in Treviso, he shares the role with South African ... Read more" ["content"]=> array(1) { ["encoded"]=> string(5036) "

Coach Crowley, from the match on November 6, could entrust the ranks to the 23-year-old Roman flanker: “But I would remain the same as always”

By dint of hearing it, the prophecy is becoming a reality. After all, Michele Lamaro was born a captain. Since July, in Treviso, he shares the role with South African scrum-half Dewaldt Duvenage. And from next week, coinciding with the Verona meeting that will lead to the three Italian test matches in November, he could also wear the armband in the national team. If the new coach Kieran Crowley really decides to replace Luca Bigi, invested with responsibility since February 2020, the number one candidate to replace him will be the Roman third line. When it is said to forge ahead: Lamaro made his debut with the major Italy last November and boasts no more than seven appearances. How long was it enough for him, at the age of 23, to confirm certain characteristics – not just technical – as a leader.

The band

“If it really happens – he says – I will reach a great milestone. It would be a source of pride: for me, for my family and for all those with whom I have worked over the years. In case I will remain the Michele I always have, animated by the passion that accompanies me. since I started playing. In Treviso, in recent weeks, I realized that the role does not involve big changes. What is different is that the teammates observe you, they take you as a reference and so any possible error does not go unnoticed. L ‘the only thing is that when they call me captain or make jokes, I get a little embarrassed. ”The beauty is that the possible debut with the ranks will not take place in just any match. But in the one against the All Blacks on Saturday 6 November at the Olimpico of his hometown. “In New Zealand – admits Gianluca’s son, Olympic sailor in Los Angeles 1984 and Seoul 1988 – I’ve never been there, but that culture fascinates me. The ranking doesn’t matter: they are the best in the world. C ‘is also the bil even win-lost games to say it, close to 80%. I grew up at Aurelio, 10 ‘from the stadium, so it will be a special occasion for me. Also because not everyone is lucky enough to play such a match. I was in the Monte Mario stands in 2016, when Tommy Boni made his debut in blue, also scoring a try for them. And I have a precedent with the Under 20s, at the World Cup in Georgia in 2017. Then my reference player is the All Black par excellence: Richie McCaw. “Captain and flanker like him.

Image man

Just Michele, for a few hours, has been standing out throughout the city together with Bauden Barrett, all star, in the launch campaign at the match: “It will be interesting to see if someone recognizes me later” smiles the future doctor in sports management (thesis defense degree is scheduled for December 12). “If last season, with Treviso, after a disastrous Pro 14, we were in desperate need of victories and we arrived at the success in the Rainbow Cup that has restored confidence to the environment – he underlines – in the national team we desperately need to return to being competitive. , even against teams like New Zealand, Argentina and Uruguay, fearsome next opponents. The Pumas are returning from a subdued Championship and will be animated by a great desire for redemption, the Teros have just won the qualification for the next World Cup and they will be well charged: I foresee a great physical clash “. 13 Treviso players have been called up for the Verona meeting. Including rookie Ivan Nemer, a 23-year-old Argentine prop equalized: “When he arrived in Italy – remembers Lamaro – he was destined for Casale, in Serie B. But he soon demonstrated his qualities. He is outgoing and competitive: if only he spoke in one language. a little more understandable … “.

We would like to say thanks to the author of this short article for this amazing content

Italy, Lamaro almost captain. All Blacks, who before: “It would be crazy”

" } ["summary"]=> string(670) "Coach Crowley, from the match on November 6, could entrust the ranks to the 23-year-old Roman flanker: “But I would remain the same as always” By dint of hearing it, the prophecy is becoming a reality. After all, Michele Lamaro was born a captain. Since July, in Treviso, he shares the role with South African ... Read more" ["atom_content"]=> string(5036) "

Coach Crowley, from the match on November 6, could entrust the ranks to the 23-year-old Roman flanker: “But I would remain the same as always”

By dint of hearing it, the prophecy is becoming a reality. After all, Michele Lamaro was born a captain. Since July, in Treviso, he shares the role with South African scrum-half Dewaldt Duvenage. And from next week, coinciding with the Verona meeting that will lead to the three Italian test matches in November, he could also wear the armband in the national team. If the new coach Kieran Crowley really decides to replace Luca Bigi, invested with responsibility since February 2020, the number one candidate to replace him will be the Roman third line. When it is said to forge ahead: Lamaro made his debut with the major Italy last November and boasts no more than seven appearances. How long was it enough for him, at the age of 23, to confirm certain characteristics – not just technical – as a leader.

The band

“If it really happens – he says – I will reach a great milestone. It would be a source of pride: for me, for my family and for all those with whom I have worked over the years. In case I will remain the Michele I always have, animated by the passion that accompanies me. since I started playing. In Treviso, in recent weeks, I realized that the role does not involve big changes. What is different is that the teammates observe you, they take you as a reference and so any possible error does not go unnoticed. L ‘the only thing is that when they call me captain or make jokes, I get a little embarrassed. ”The beauty is that the possible debut with the ranks will not take place in just any match. But in the one against the All Blacks on Saturday 6 November at the Olimpico of his hometown. “In New Zealand – admits Gianluca’s son, Olympic sailor in Los Angeles 1984 and Seoul 1988 – I’ve never been there, but that culture fascinates me. The ranking doesn’t matter: they are the best in the world. C ‘is also the bil even win-lost games to say it, close to 80%. I grew up at Aurelio, 10 ‘from the stadium, so it will be a special occasion for me. Also because not everyone is lucky enough to play such a match. I was in the Monte Mario stands in 2016, when Tommy Boni made his debut in blue, also scoring a try for them. And I have a precedent with the Under 20s, at the World Cup in Georgia in 2017. Then my reference player is the All Black par excellence: Richie McCaw. “Captain and flanker like him.

Image man

Just Michele, for a few hours, has been standing out throughout the city together with Bauden Barrett, all star, in the launch campaign at the match: “It will be interesting to see if someone recognizes me later” smiles the future doctor in sports management (thesis defense degree is scheduled for December 12). “If last season, with Treviso, after a disastrous Pro 14, we were in desperate need of victories and we arrived at the success in the Rainbow Cup that has restored confidence to the environment – he underlines – in the national team we desperately need to return to being competitive. , even against teams like New Zealand, Argentina and Uruguay, fearsome next opponents. The Pumas are returning from a subdued Championship and will be animated by a great desire for redemption, the Teros have just won the qualification for the next World Cup and they will be well charged: I foresee a great physical clash “. 13 Treviso players have been called up for the Verona meeting. Including rookie Ivan Nemer, a 23-year-old Argentine prop equalized: “When he arrived in Italy – remembers Lamaro – he was destined for Casale, in Serie B. But he soon demonstrated his qualities. He is outgoing and competitive: if only he spoke in one language. a little more understandable … “.

We would like to say thanks to the author of this short article for this amazing content

Italy, Lamaro almost captain. All Blacks, who before: “It would be crazy”

" ["date_timestamp"]=> int(1640635406) } [8]=> array(11) { ["title"]=> string(91) "The best young people of Milan: from Alesi to Traoré and Gala. And Colombo shines on loan" ["link"]=> string(122) "https://redhatbeauty.com/football/the-best-young-people-of-milan-from-alesi-to-traore-and-gala-and-colombo-shines-on-loan/" ["dc"]=> array(1) { ["creator"]=> string(10) "Debby Kent" } ["pubdate"]=> string(31) "Mon, 27 Dec 2021 19:47:19 +0000" ["category"]=> string(52) "FootballAlesiColomboGalaloanMilanpeopleshinesTraoré" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3441" ["description"]=> string(703) "Pioli could draw some useful cards from the youth sector. The “panzer” Rossi, the Swede Roback but not only. With a keen eye on those who have only been away for a year Francesco Pietrella December 27 – Milano Milan is the ideal place for a young talent. Pioli’s work says it, the ranking confirms ... Read more" ["content"]=> array(1) { ["encoded"]=> string(8434) "

Pioli could draw some useful cards from the youth sector. The “panzer” Rossi, the Swede Roback but not only. With a keen eye on those who have only been away for a year

Francesco Pietrella

Milan is the ideal place for a young talent. Pioli’s work says it, the ranking confirms it, the data confirm it: the Rossoneri are fourth for average age in Serie A, if we consider the 11 owner (25.5 years old). Before them only Spezia, Empoli and Turin. It’s spring? Is there any baby that Pioli can use? The championship goes like this for the Giunti boys, the team is thirteenth at 17 points, while in the Youth League they have collected two draws in 6 games. However, despite the bad moment, there are some interesting talents. Who knows if during the year one of them will be able to suit Pioli.

Alesi, the 10th of Alcamo

Google his name and you will find a couple of things. The first is that United had looked for him years ago, the second is the super goal scored with the Under 15 team in 2019. Gabriele Alesi is 17 years old, is a playmaker and comes from Alcamo, Sicily, near Trapani. Two years ago he decided to bewitch Milan with a sudden goal from midfield. Scenario: Vismara field, 1-1, Verona scores and brings the ball to the white circle of the median, convinced that the draw is a done thing, but Alesi is not there. He gets the ball and kicks from 50 meters. Goals. His teammates enter the field, he takes off his shirt and runs fast. The likes of Maldini and Sheva arrive on social media, while the network goes around the world. “Do you score goals in recovery but do you want to win? Shoot from midfield! ”. AC Milan writes on Instagram. Alesi is a number 10, he can also make the second striker, this year he played 14 games scoring a goal and serving an assist. He has a contract until 2023. To keep an eye on.

Traoré, the sixteen-year-old gold

He understood immediately that Milan was in destiny: Chaka Traoré was the first 2004 to debut in Serie A. Five minutes on the pitch against Ibra, on 10 April 2021 in Parma-Milan 1-3, where he also nearly scored. . Predestined, especially because D’Aversa made him play three more times: two in the top flight (Lazio and Sampdoria), one in the Italian Cup (one minute at the Olimpico against the biancocelesti). Hired in the summer for around 600,000 euros, Traoré is an attacking winger with an easy dribbling and a lot of flair. Those who know him say it will be done. This year he played 17 games, scored 5 goals and served 3 assists. Ivoriano, right-handed who plays on the left, until a few years ago was called Cissè and played with this name. Those who accompanied him to Italy from the Ivory Coast violated the rules for underage players. He made the authorities believe that the boy was arriving in our country for an alleged family reunion. A lie. After a few months and Chaka – at the time still Cissè – was noticed by the amateurs of the Audace. Play a few months, it does well, but then it turns out everything. The person who brought him to Italy is arrested, he continues to amaze. In 2019 he sees Fausto Pizzi, former head of the youth sector of Parma, and immediately brings him to the yellow and blue. The rest is history.

Gala, the 2004 beacon

Another very owner of Giunti. Antonio Gala is another well-spoken 2004 player, a quality midfielder with 18 appearances, three goals and two assists. Born and raised in Piscinola, a suburb of Naples, Gala arrived at Milan in 2018 after touching Lazio. The Biancocelesti had brought him to Holland to play a high-level tour against Psg, Ajax and City, but the Rossoneri were quicker. Raffaele D’Auria, president of Internapoli Kennedy, the club where he started playing, spoke of him as “one of the strongest young people in all of Campania”. Rossonero thanks to a won tournament and Gallipoli. It is inspired by Zidane.

Rossi, the “panzer” of Rome

Here it is the tip of weight, one meter and 80 of doors, networks and presence in the area. Last year they called him the “panzer” because of the many goals in the Under 17 team, 13 in 13 games. A couple of seasons ago he lost the U15 championship in the final against Roma. This year he only made a couple of them in the Coppa Italia Primavera. Leonardo Rossi was born in Rome and has been playing for Milan since 2018. The Rossoneri snatched him from the Giallorossi and brought him to the Duomo. Born in 2004 like Traoré, Gala and Alesi, Leo was the star of the very young Roma regional teams, the first quick and quick striker with some flashes even in the blue youth teams: 5 goals with the Under 15s, 3 with the U16. This year 4 goals in 21 games.

The others, from Kerkez to Roback

The first name is in defense: beyond Jungdal, promoted to the first team after Maignan’s stoppage, keep an eye on Milos Kerkez, an 18-year-old Hungarian left-back. In the summer he stood out by scoring a couple of goals at the Pro Sesto in a friendly. Nineteen games in the season. Another one to keep an eye on is Emil Roback, Swedish like Ibra, quick and snappy toe. He has already made some bench in the first team, this year he scored 6 goals. Chapter 2002: the most interesting are Enrico Di Gesù and Giovanni Robotti, quality midfielders, and Antonio Capone, second striker / attacking midfielder. Curiosity: his brother Christian plays in Serie B with Ternana. In 2016 he made his debut with Gasp’s Atalanta in the Italian Cup.

Borrowed

Some guys are out on loan in Italy. In addition to Pobega, 22, four goals and an assist in Turin, there is Lorenzo Colombo at Spal. This year he scored 6 goals in 17 Serie B games, with one assist. Contract until 2024, last year he was with Pioli until January. In Serie B there are also Marco Brescianini, class of two thousand, 5 games in Monza, Gabriele Bellodi in Alessandria (also 2000, defender) and Frank Tsadjout, striker of Pordenone (’99, one goal in 15 games). Chapter Serie C: Riccardo Tonin, 2001, scored a goal in Cesena, Marco Frigerio is the owner of Lucchese (2001, midfielder), while Luan Capanni plays at Viterbese (2 goals in 22 games, 2001). In addition to them also Alessandro Sala al Renate (2001, midfielder) and Antonio Mionic al Montevarchi (owner with 16 games, also 2001).

We would love to thank the writer of this write-up for this remarkable content

The best young people of Milan: from Alesi to Traoré and Gala. And Colombo shines on loan

" } ["summary"]=> string(703) "Pioli could draw some useful cards from the youth sector. The “panzer” Rossi, the Swede Roback but not only. With a keen eye on those who have only been away for a year Francesco Pietrella December 27 – Milano Milan is the ideal place for a young talent. Pioli’s work says it, the ranking confirms ... Read more" ["atom_content"]=> string(8434) "

Pioli could draw some useful cards from the youth sector. The “panzer” Rossi, the Swede Roback but not only. With a keen eye on those who have only been away for a year

Francesco Pietrella

Milan is the ideal place for a young talent. Pioli’s work says it, the ranking confirms it, the data confirm it: the Rossoneri are fourth for average age in Serie A, if we consider the 11 owner (25.5 years old). Before them only Spezia, Empoli and Turin. It’s spring? Is there any baby that Pioli can use? The championship goes like this for the Giunti boys, the team is thirteenth at 17 points, while in the Youth League they have collected two draws in 6 games. However, despite the bad moment, there are some interesting talents. Who knows if during the year one of them will be able to suit Pioli.

Alesi, the 10th of Alcamo

Google his name and you will find a couple of things. The first is that United had looked for him years ago, the second is the super goal scored with the Under 15 team in 2019. Gabriele Alesi is 17 years old, is a playmaker and comes from Alcamo, Sicily, near Trapani. Two years ago he decided to bewitch Milan with a sudden goal from midfield. Scenario: Vismara field, 1-1, Verona scores and brings the ball to the white circle of the median, convinced that the draw is a done thing, but Alesi is not there. He gets the ball and kicks from 50 meters. Goals. His teammates enter the field, he takes off his shirt and runs fast. The likes of Maldini and Sheva arrive on social media, while the network goes around the world. “Do you score goals in recovery but do you want to win? Shoot from midfield! ”. AC Milan writes on Instagram. Alesi is a number 10, he can also make the second striker, this year he played 14 games scoring a goal and serving an assist. He has a contract until 2023. To keep an eye on.

Traoré, the sixteen-year-old gold

He understood immediately that Milan was in destiny: Chaka Traoré was the first 2004 to debut in Serie A. Five minutes on the pitch against Ibra, on 10 April 2021 in Parma-Milan 1-3, where he also nearly scored. . Predestined, especially because D’Aversa made him play three more times: two in the top flight (Lazio and Sampdoria), one in the Italian Cup (one minute at the Olimpico against the biancocelesti). Hired in the summer for around 600,000 euros, Traoré is an attacking winger with an easy dribbling and a lot of flair. Those who know him say it will be done. This year he played 17 games, scored 5 goals and served 3 assists. Ivoriano, right-handed who plays on the left, until a few years ago was called Cissè and played with this name. Those who accompanied him to Italy from the Ivory Coast violated the rules for underage players. He made the authorities believe that the boy was arriving in our country for an alleged family reunion. A lie. After a few months and Chaka – at the time still Cissè – was noticed by the amateurs of the Audace. Play a few months, it does well, but then it turns out everything. The person who brought him to Italy is arrested, he continues to amaze. In 2019 he sees Fausto Pizzi, former head of the youth sector of Parma, and immediately brings him to the yellow and blue. The rest is history.

Gala, the 2004 beacon

Another very owner of Giunti. Antonio Gala is another well-spoken 2004 player, a quality midfielder with 18 appearances, three goals and two assists. Born and raised in Piscinola, a suburb of Naples, Gala arrived at Milan in 2018 after touching Lazio. The Biancocelesti had brought him to Holland to play a high-level tour against Psg, Ajax and City, but the Rossoneri were quicker. Raffaele D’Auria, president of Internapoli Kennedy, the club where he started playing, spoke of him as “one of the strongest young people in all of Campania”. Rossonero thanks to a won tournament and Gallipoli. It is inspired by Zidane.

Rossi, the “panzer” of Rome

Here it is the tip of weight, one meter and 80 of doors, networks and presence in the area. Last year they called him the “panzer” because of the many goals in the Under 17 team, 13 in 13 games. A couple of seasons ago he lost the U15 championship in the final against Roma. This year he only made a couple of them in the Coppa Italia Primavera. Leonardo Rossi was born in Rome and has been playing for Milan since 2018. The Rossoneri snatched him from the Giallorossi and brought him to the Duomo. Born in 2004 like Traoré, Gala and Alesi, Leo was the star of the very young Roma regional teams, the first quick and quick striker with some flashes even in the blue youth teams: 5 goals with the Under 15s, 3 with the U16. This year 4 goals in 21 games.

The others, from Kerkez to Roback

The first name is in defense: beyond Jungdal, promoted to the first team after Maignan’s stoppage, keep an eye on Milos Kerkez, an 18-year-old Hungarian left-back. In the summer he stood out by scoring a couple of goals at the Pro Sesto in a friendly. Nineteen games in the season. Another one to keep an eye on is Emil Roback, Swedish like Ibra, quick and snappy toe. He has already made some bench in the first team, this year he scored 6 goals. Chapter 2002: the most interesting are Enrico Di Gesù and Giovanni Robotti, quality midfielders, and Antonio Capone, second striker / attacking midfielder. Curiosity: his brother Christian plays in Serie B with Ternana. In 2016 he made his debut with Gasp’s Atalanta in the Italian Cup.

Borrowed

Some guys are out on loan in Italy. In addition to Pobega, 22, four goals and an assist in Turin, there is Lorenzo Colombo at Spal. This year he scored 6 goals in 17 Serie B games, with one assist. Contract until 2024, last year he was with Pioli until January. In Serie B there are also Marco Brescianini, class of two thousand, 5 games in Monza, Gabriele Bellodi in Alessandria (also 2000, defender) and Frank Tsadjout, striker of Pordenone (’99, one goal in 15 games). Chapter Serie C: Riccardo Tonin, 2001, scored a goal in Cesena, Marco Frigerio is the owner of Lucchese (2001, midfielder), while Luan Capanni plays at Viterbese (2 goals in 22 games, 2001). In addition to them also Alessandro Sala al Renate (2001, midfielder) and Antonio Mionic al Montevarchi (owner with 16 games, also 2001).

We would love to thank the writer of this write-up for this remarkable content

The best young people of Milan: from Alesi to Traoré and Gala. And Colombo shines on loan

" ["date_timestamp"]=> int(1640634439) } [9]=> array(11) { ["title"]=> string(73) "HIV an infection: Better understanding the reservoir of virus in the body" ["link"]=> string(115) "https://redhatbeauty.com/healthandscience/hiv-an-infection-better-understanding-the-reservoir-of-virus-in-the-body/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Mon, 27 Dec 2021 19:01:31 +0000" ["category"]=> string(61) "Health And SciencebodyHIVinfectionreservoirunderstandingvirus" ["guid"]=> string(32) "https://redhatbeauty.com/?p=3439" ["description"]=> string(770) "Journal Reference: Manuel Albanese, Adrian Ruhle, Jennifer Mittermaier, Ernesto Mejías-Pérez, Madeleine Gapp, Andreas Linder, Niklas A. Schmacke, Katharina Hofmann, Alexandru A. Hennrich, David N. Levy, Andreas Humpe, Karl-Klaus Conzelmann, Veit Hornung, Oliver T. Fackler, Oliver T. Keppler. Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4 T cells allows complex functional analyses. ... Read more" ["content"]=> array(1) { ["encoded"]=> string(4876) "

Journal Reference:

  1. Manuel Albanese, Adrian Ruhle, Jennifer Mittermaier, Ernesto Mejías-Pérez, Madeleine Gapp, Andreas Linder, Niklas A. Schmacke, Katharina Hofmann, Alexandru A. Hennrich, David N. Levy, Andreas Humpe, Karl-Klaus Conzelmann, Veit Hornung, Oliver T. Fackler, Oliver T. Keppler. Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4 T cells allows complex functional analyses. Nature Methods, 2021; DOI: 10.1038/s41592-021-01328-8

CD4+ T cells are important parts of the immune system and play a key role in defending the body against pathogens. As they possess a great variety of defense mechanisms against HIV in their resting state, they are infected only very rarely — but these few infected cells form a latent reservoir for HIV in the body that currently cannot be reached by antiviral drugs. Consequently, the virus can spread again from there after activation of the CD4+ T cells. Understanding how HIV interacts with resting CD4+ T cells is essential for finding new therapeutic approaches. Scientists led by Prof. Oliver T. Keppler from the Max von Pettenkofer Institute at LMU have now developed a method that for the first time allows these specific immune cells to be genetically manipulated under physiological conditions in an efficient and uncomplicated manner. As the authors report in the journal Nature Methods, this permits previously unobtainable insights into the biology of these cells.

Resting CD4+ T cells had been scarcely amenable to genetic manipulations, because the available methods generally presuppose dividing cells, as Keppler explains. “And resting cells do not divide by definition.” As the first step in the development of the new method, the team of scientists optimized the cultivation conditions. As a result, the researchers were able to keep these cells alive in the laboratory after extracting them from the blood of healthy donors not just for 3-4 days as before, but for up to six weeks. The decisive progress came with an advance in nucleofection, a special method that allows reagents to be delivered into the nucleus of a cell. Using this technique, the researchers introduced the genetic scissors CRISPR-Cas into resting CD4+ T cells, enabling them to make targeted modifications to the genome of the host cells — for example, by eliminating genes by means of so-called knockouts. “This combination worked very efficiently, and we were able to reach and genetically manipulate around 98 percent of the cells. Moreover, we did this without activating the CD4+ T cells,” says Keppler. “What was particularly exciting was that we were able to eliminate up to six genes simultaneously with high efficiency by means of a single nucleofection. Nobody had managed to do that in primary cells before — and we did it with cells isolated from an intact organ.”

In the future, the researchers will thus be able to eliminate individual genes and whole signaling pathways and analyze their functions. By knocking out the corresponding genes, they have already managed to clarify whether four previously controversial cellular factors play a role in infection with HIV or not.

On top of this, they pursued a second “knock-in” approach, whereby additional or slightly modified genes are inserted, such as a gene for green fluorescent protein (GFP). With the help of this protein, researchers can analyze how the activity of a target gene changes under certain conditions, or they can mark specific proteins. “All these things together give us the opportunity for the first time to investigate the interaction of HIV with human resting CD4+ T cells under physiological conditions,” explains Adrian Ruhle, co-lead author of the study. “But we can also investigate these cells better in their general role as immune cells beyond HIV.” In the long term, the researchers hope that having a better understanding of the biology of these cells will lead to new approaches for the total elimination of HIV from the bodies of patients, as there are still around 37 million people worldwide infected with the virus.

We would love to thank the writer of this short article for this incredible web content

HIV an infection: Better understanding the reservoir of virus in the body

" } ["summary"]=> string(770) "Journal Reference: Manuel Albanese, Adrian Ruhle, Jennifer Mittermaier, Ernesto Mejías-Pérez, Madeleine Gapp, Andreas Linder, Niklas A. Schmacke, Katharina Hofmann, Alexandru A. Hennrich, David N. Levy, Andreas Humpe, Karl-Klaus Conzelmann, Veit Hornung, Oliver T. Fackler, Oliver T. Keppler. Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4 T cells allows complex functional analyses. ... Read more" ["atom_content"]=> string(4876) "

Journal Reference:

  1. Manuel Albanese, Adrian Ruhle, Jennifer Mittermaier, Ernesto Mejías-Pérez, Madeleine Gapp, Andreas Linder, Niklas A. Schmacke, Katharina Hofmann, Alexandru A. Hennrich, David N. Levy, Andreas Humpe, Karl-Klaus Conzelmann, Veit Hornung, Oliver T. Fackler, Oliver T. Keppler. Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4 T cells allows complex functional analyses. Nature Methods, 2021; DOI: 10.1038/s41592-021-01328-8

CD4+ T cells are important parts of the immune system and play a key role in defending the body against pathogens. As they possess a great variety of defense mechanisms against HIV in their resting state, they are infected only very rarely — but these few infected cells form a latent reservoir for HIV in the body that currently cannot be reached by antiviral drugs. Consequently, the virus can spread again from there after activation of the CD4+ T cells. Understanding how HIV interacts with resting CD4+ T cells is essential for finding new therapeutic approaches. Scientists led by Prof. Oliver T. Keppler from the Max von Pettenkofer Institute at LMU have now developed a method that for the first time allows these specific immune cells to be genetically manipulated under physiological conditions in an efficient and uncomplicated manner. As the authors report in the journal Nature Methods, this permits previously unobtainable insights into the biology of these cells.

Resting CD4+ T cells had been scarcely amenable to genetic manipulations, because the available methods generally presuppose dividing cells, as Keppler explains. “And resting cells do not divide by definition.” As the first step in the development of the new method, the team of scientists optimized the cultivation conditions. As a result, the researchers were able to keep these cells alive in the laboratory after extracting them from the blood of healthy donors not just for 3-4 days as before, but for up to six weeks. The decisive progress came with an advance in nucleofection, a special method that allows reagents to be delivered into the nucleus of a cell. Using this technique, the researchers introduced the genetic scissors CRISPR-Cas into resting CD4+ T cells, enabling them to make targeted modifications to the genome of the host cells — for example, by eliminating genes by means of so-called knockouts. “This combination worked very efficiently, and we were able to reach and genetically manipulate around 98 percent of the cells. Moreover, we did this without activating the CD4+ T cells,” says Keppler. “What was particularly exciting was that we were able to eliminate up to six genes simultaneously with high efficiency by means of a single nucleofection. Nobody had managed to do that in primary cells before — and we did it with cells isolated from an intact organ.”

In the future, the researchers will thus be able to eliminate individual genes and whole signaling pathways and analyze their functions. By knocking out the corresponding genes, they have already managed to clarify whether four previously controversial cellular factors play a role in infection with HIV or not.

On top of this, they pursued a second “knock-in” approach, whereby additional or slightly modified genes are inserted, such as a gene for green fluorescent protein (GFP). With the help of this protein, researchers can analyze how the activity of a target gene changes under certain conditions, or they can mark specific proteins. “All these things together give us the opportunity for the first time to investigate the interaction of HIV with human resting CD4+ T cells under physiological conditions,” explains Adrian Ruhle, co-lead author of the study. “But we can also investigate these cells better in their general role as immune cells beyond HIV.” In the long term, the researchers hope that having a better understanding of the biology of these cells will lead to new approaches for the total elimination of HIV from the bodies of patients, as there are still around 37 million people worldwide infected with the virus.

We would love to thank the writer of this short article for this incredible web content

HIV an infection: Better understanding the reservoir of virus in the body

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