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Meghan Markle wins legal battle against British tabloid
Ancient lineage of algae found to include five ?cryptic? species
Volcanic fertilization of the oceans drove severe mass extinction
Machine learning helps mathematicians make new connections
Toro show for half an hour, then red in Singo and Empoli comeback
Breastfeeding: my history, silicone nipples and lessons learned ? Fashionism
One of the most important Final Fantasy, and its role in Endwalker
Targeting the brain?s immune cells may help prevent or treat Alzheimer?s disease
MLB: It?s official, Major League Baseball?s work stoppage begins, the first in 27 years
New computational approach predicts chemical reactions at high temperatures

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                    [title] => Meghan Markle wins legal battle against British tabloid
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                    [pubdate] => Fri, 03 Dec 2021 00:13:38 +0000
                    [category] => World NewsbattleBritishlegalMarkleMeghantabloidwins
                    [guid] => https://redhatbeauty.com/?p=8004
                    [description] => The Duchess of Sussex, Meghan Markle, at a concert in New York City on September 25, 2021. CAITLIN OCHS / REUTERS Former actress Meghan Markle won her case on Thursday, December 2, against the British tabloid Mail on Sunday, condemned for the publication of a letter she had written to her father, a victory likely ... Read more
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Former actress Meghan Markle won her case on Thursday, December 2, against the British tabloid Mail on Sunday, condemned for the publication of a letter she had written to her father, a victory likely to reshape a tabloid press cruel and deceptive, according to Prince Harry’s wife.

Saying disappointed by the decision of the Court of Appeal which rejected his appeal against his conviction for invasion of privacy, the editor of Mail on Sunday, the Associated Newspapers Limited (ANL) group, has announced that it is considering taking the matter to the Supreme Court.

The mass-circulation newspaper was challenging a February court ruling that the publication of Meghan’s letter to her father was “Manifestly excessive and therefore illegal”. He particularly regretted that the decision had been taken at first instance without going through a due process.

Read also Article reserved for our subscribers Prince Harry and Meghan Markle wreak havoc in UK media

Sentenced to pay 530,000 euros to Meghan Markle

“The Court of Appeal upholds the judge’s decision that the Duchess could reasonably expect respect for her privacy”said Judge Geoffrey Vos, pointing out that the contents of the letter were “Personal, private and did not present a legitimate interest in the public interest”.

“What matters most is that we are now collectively brave enough to reshape a tabloid industry that pushes people to be cruel and takes advantage of the lies and the pain they create.”, rejoiced Mme Markle after the court of appeal decision. Denouncing on multiple occasions the pressure of the media on his couple, Harry, 37, has also made it the main reason for his withdrawal from the royal family and his exile in California with his wife, where they live with their two children.

Read also Article reserved for our subscribers Has the British media been racist against Meghan Markle?

In this missive published in 2018, shortly after her marriage to Prince Harry, the Duchess of Sussex asked her father, Thomas Markle, 77, to stop talking and lying in the media about their broken relationship. the Mail on Sunday had been condemned to report in “one” of his legal defeat, and his publisher to pay 450,000 pounds (530,000 euros) to Mr.me Markle for his legal costs. But the tabloid had argued in its appeal, reviewed in November, that she wrote the letter knowing it could be disclosed.

The letter written with the possibility “that it might leak”

Meghan Markle denounced the practices “Without rules” of this publication, which she said made “A simple and extremely convoluted business, in order to generate even more titles and sell more newspapers ? a model that rewards chaos rather than truth ?.

In order to support his claims, the Mail on Sunday highlighted during the appeal hearings the testimony of Jason Knauf, the couple’s former communications secretary, who said that the draft letter had been drafted with in mind “That she could flee”. In a written testimony, Meghan had refuted this claim, believing it to be only a “Possibility”.

Bringing water to the tabloid mill, which wanted to demonstrate that it regularly sought to influence public opinion, Mr. Knauf had also said to have provided on behalf of Meghan and Harry private information to the authors of the unofficial biography of the royal couple, Finding Freedom (Harry and Meghan, free, in its French translation). Mme Markle finally recognized it and apologized for having misled justice by not having specified it in the first instance, a backpedal which earned him the mockery of the tabloids.

Read also Article reserved for our subscribers Meghan Markle and Harry’s interview, new crisis for the British royal family

She argued, however, that the information shared with the authors was “Far from very detailed personal information” published by the Mail on Sunday. But the ANL spokesperson stressed that“No evidence has been subjected to cross-examination, as it should be, especially when the evidence provided by Mr Knauf raises questions as to the credibility of the Duchess”.

The World with AFP

We would like to thank the author of this write-up for this remarkable content

Meghan Markle wins legal battle against British tabloid

) [summary] => The Duchess of Sussex, Meghan Markle, at a concert in New York City on September 25, 2021. CAITLIN OCHS / REUTERS Former actress Meghan Markle won her case on Thursday, December 2, against the British tabloid Mail on Sunday, condemned for the publication of a letter she had written to her father, a victory likely ... Read more [atom_content] =>

Former actress Meghan Markle won her case on Thursday, December 2, against the British tabloid Mail on Sunday, condemned for the publication of a letter she had written to her father, a victory likely to reshape a tabloid press cruel and deceptive, according to Prince Harry’s wife.

Saying disappointed by the decision of the Court of Appeal which rejected his appeal against his conviction for invasion of privacy, the editor of Mail on Sunday, the Associated Newspapers Limited (ANL) group, has announced that it is considering taking the matter to the Supreme Court.

The mass-circulation newspaper was challenging a February court ruling that the publication of Meghan’s letter to her father was “Manifestly excessive and therefore illegal”. He particularly regretted that the decision had been taken at first instance without going through a due process.

Read also Article reserved for our subscribers Prince Harry and Meghan Markle wreak havoc in UK media

Sentenced to pay 530,000 euros to Meghan Markle

“The Court of Appeal upholds the judge’s decision that the Duchess could reasonably expect respect for her privacy”said Judge Geoffrey Vos, pointing out that the contents of the letter were “Personal, private and did not present a legitimate interest in the public interest”.

“What matters most is that we are now collectively brave enough to reshape a tabloid industry that pushes people to be cruel and takes advantage of the lies and the pain they create.”, rejoiced Mme Markle after the court of appeal decision. Denouncing on multiple occasions the pressure of the media on his couple, Harry, 37, has also made it the main reason for his withdrawal from the royal family and his exile in California with his wife, where they live with their two children.

Read also Article reserved for our subscribers Has the British media been racist against Meghan Markle?

In this missive published in 2018, shortly after her marriage to Prince Harry, the Duchess of Sussex asked her father, Thomas Markle, 77, to stop talking and lying in the media about their broken relationship. the Mail on Sunday had been condemned to report in “one” of his legal defeat, and his publisher to pay 450,000 pounds (530,000 euros) to Mr.me Markle for his legal costs. But the tabloid had argued in its appeal, reviewed in November, that she wrote the letter knowing it could be disclosed.

The letter written with the possibility “that it might leak”

Meghan Markle denounced the practices “Without rules” of this publication, which she said made “A simple and extremely convoluted business, in order to generate even more titles and sell more newspapers ? a model that rewards chaos rather than truth ?.

In order to support his claims, the Mail on Sunday highlighted during the appeal hearings the testimony of Jason Knauf, the couple’s former communications secretary, who said that the draft letter had been drafted with in mind “That she could flee”. In a written testimony, Meghan had refuted this claim, believing it to be only a “Possibility”.

Bringing water to the tabloid mill, which wanted to demonstrate that it regularly sought to influence public opinion, Mr. Knauf had also said to have provided on behalf of Meghan and Harry private information to the authors of the unofficial biography of the royal couple, Finding Freedom (Harry and Meghan, free, in its French translation). Mme Markle finally recognized it and apologized for having misled justice by not having specified it in the first instance, a backpedal which earned him the mockery of the tabloids.

Read also Article reserved for our subscribers Meghan Markle and Harry’s interview, new crisis for the British royal family

She argued, however, that the information shared with the authors was “Far from very detailed personal information” published by the Mail on Sunday. But the ANL spokesperson stressed that“No evidence has been subjected to cross-examination, as it should be, especially when the evidence provided by Mr Knauf raises questions as to the credibility of the Duchess”.

The World with AFP

We would like to thank the author of this write-up for this remarkable content

Meghan Markle wins legal battle against British tabloid

[date_timestamp] => 1638490418 ) [1] => Array ( [title] => Ancient lineage of algae found to include five ?cryptic? species [link] => https://redhatbeauty.com/healthandscience/ancient-lineage-of-algae-found-to-include-five-cryptic-species/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 23:45:43 +0000 [category] => Health And Sciencealgaeancientcrypticincludelineagespecies [guid] => https://redhatbeauty.com/?p=7999 [description] => Journal Reference: Iker Irisarri, Tatyana Darienko, Thomas Pröschold, Janine M. R. Fürst-Jansen, Mahwash Jamy, Jan de Vries. Unexpected cryptic species among streptophyte algae most distant to land plants. Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1963) DOI: 10.1098/rspb.2021.2168 While small in number and vanishingly rare, these humble algae are valuable in terms ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Iker Irisarri, Tatyana Darienko, Thomas Pröschold, Janine M. R. Fürst-Jansen, Mahwash Jamy, Jan de Vries. Unexpected cryptic species among streptophyte algae most distant to land plants. Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1963) DOI: 10.1098/rspb.2021.2168

While small in number and vanishingly rare, these humble algae are valuable in terms of the evolutionary pathways they reveal. They diverged from land plants over a billion years ago, making them descendants of the ancient algal ancestor that also gave rise to modern land plants (and various other algae). The study started by tracking down and screening all known algae that can be assigned to Chlorokybus, including cultures from public algal collections and fresh samples obtained in Ukraine, Chile, and Costa Rica. ?We even tried to collect Chlorokybus in the place where it was first described in the 1940s, living on a stone monument in the Schönbrunn Palace in Vienna. But we could not find it, probably because the monument had been recently restored,? says Dr Tatyana Darienko.

The researchers then conducted genetic analyses on the collected samples. The first analysis, based on just a few genes, showed marked genetic divergences among the various isolated algae. Hundreds of gene sequences obtained through large-scale genomic sequencing confirmed these unexpected results. This led the authors to recognize that there were actually five distinct species hiding under a single common name. These are called ?cryptic species? to reflect the difficulty or impossibility of telling them apart by simple observation. In fact, traditional microscopy revealed no obvious differences between the five species. However, the genetic data told a different story: there were clear differences in gene expression, proving there were genetic differences among the species that are not observable to the naked eye.

Lead author Dr Iker Irisarri, University of Göttingen, explained, ?The fact that these algae look so similar is a real surprise, given that some of these species might have diverged from each other over 70 million years ago! But the genetic data are unambiguous.? This study sheds new light into the biodiversity of a little studied algal group that occupies a key evolutionary position, being a close relative of land plants. This has important implications for our understanding of plant form and function. ?Accounting for the real species diversity of this group of algae is paramount for ongoing comparative genomic studies that help explain the origin, adaptation and development of land plants and their algal relatives? says Professor Jan de Vries, University of Göttingen.

We want to give thanks to the author of this write-up for this outstanding content

Ancient lineage of algae found to include five ?cryptic? species

) [summary] => Journal Reference: Iker Irisarri, Tatyana Darienko, Thomas Pröschold, Janine M. R. Fürst-Jansen, Mahwash Jamy, Jan de Vries. Unexpected cryptic species among streptophyte algae most distant to land plants. Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1963) DOI: 10.1098/rspb.2021.2168 While small in number and vanishingly rare, these humble algae are valuable in terms ... Read more [atom_content] =>

Journal Reference:

  1. Iker Irisarri, Tatyana Darienko, Thomas Pröschold, Janine M. R. Fürst-Jansen, Mahwash Jamy, Jan de Vries. Unexpected cryptic species among streptophyte algae most distant to land plants. Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1963) DOI: 10.1098/rspb.2021.2168

While small in number and vanishingly rare, these humble algae are valuable in terms of the evolutionary pathways they reveal. They diverged from land plants over a billion years ago, making them descendants of the ancient algal ancestor that also gave rise to modern land plants (and various other algae). The study started by tracking down and screening all known algae that can be assigned to Chlorokybus, including cultures from public algal collections and fresh samples obtained in Ukraine, Chile, and Costa Rica. ?We even tried to collect Chlorokybus in the place where it was first described in the 1940s, living on a stone monument in the Schönbrunn Palace in Vienna. But we could not find it, probably because the monument had been recently restored,? says Dr Tatyana Darienko.

The researchers then conducted genetic analyses on the collected samples. The first analysis, based on just a few genes, showed marked genetic divergences among the various isolated algae. Hundreds of gene sequences obtained through large-scale genomic sequencing confirmed these unexpected results. This led the authors to recognize that there were actually five distinct species hiding under a single common name. These are called ?cryptic species? to reflect the difficulty or impossibility of telling them apart by simple observation. In fact, traditional microscopy revealed no obvious differences between the five species. However, the genetic data told a different story: there were clear differences in gene expression, proving there were genetic differences among the species that are not observable to the naked eye.

Lead author Dr Iker Irisarri, University of Göttingen, explained, ?The fact that these algae look so similar is a real surprise, given that some of these species might have diverged from each other over 70 million years ago! But the genetic data are unambiguous.? This study sheds new light into the biodiversity of a little studied algal group that occupies a key evolutionary position, being a close relative of land plants. This has important implications for our understanding of plant form and function. ?Accounting for the real species diversity of this group of algae is paramount for ongoing comparative genomic studies that help explain the origin, adaptation and development of land plants and their algal relatives? says Professor Jan de Vries, University of Göttingen.

We want to give thanks to the author of this write-up for this outstanding content

Ancient lineage of algae found to include five ?cryptic? species

[date_timestamp] => 1638488743 ) [2] => Array ( [title] => Volcanic fertilization of the oceans drove severe mass extinction [link] => https://redhatbeauty.com/healthandscience/volcanic-fertilization-of-the-oceans-drove-severe-mass-extinction/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 22:28:38 +0000 [category] => Health And SciencedroveextinctionfertilizationmassoceanssevereVolcanic [guid] => https://redhatbeauty.com/?p=7995 [description] => Journal Reference: Jack Longman, Benjamin J. W. Mills, Hayley R. Manners, Thomas M. Gernon & Martin R. Palmer. Late Ordovician climate change and extinctions driven by elevated volcanic nutrient supply. Nature Geoscience, 2021 DOI: 10.1038/s41561-021-00855-5 The researchers, working with colleagues at the University of Oldenburg, the University of Leeds and the University of Plymouth, studied ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Jack Longman, Benjamin J. W. Mills, Hayley R. Manners, Thomas M. Gernon & Martin R. Palmer. Late Ordovician climate change and extinctions driven by elevated volcanic nutrient supply. Nature Geoscience, 2021 DOI: 10.1038/s41561-021-00855-5

The researchers, working with colleagues at the University of Oldenburg, the University of Leeds and the University of Plymouth, studied the effects of volcanic ash and lava on ocean chemistry during a period of extreme environmental change around 450 million years ago. Their findings are published in the journal Nature Geoscience.

This period brought about intense planetary cooling, which culminated in a glaciation and the major ?Late Ordovician Mass Extinction?. This extinction led to the loss of about 85% of species dwelling in the oceans, reshaping the course of evolution of life on Earth.

?It?s been suggested that global cooling was driven by an increase in phosphorus input to the oceans? says Dr Jack Longman, lead author of the study based at the University of Oldenburg, and previously a postdoctoral researcher at Southampton. ?Phosphorus is one of the key elements of life, determining the pace at which tiny aquatic organisms like algae can use photosynthesis to convert carbon dioxide (CO2) into organic matter.? These organisms eventually settle to the seabed and are buried, ultimately reducing levels of carbon dioxide in the atmosphere, which then causes cooling.

?The unresolved puzzle is why glaciation and extinction occurred in two distinct phases at this time, separated by about 10 million years,? states Dr Tom Gernon, Associate Professor at the University of Southampton and co-author of the study. ?That requires some mechanism to pulse the supply of phosphorus, which is hard to explain.?

The team identified that two exceptionally large pulses of volcanic activity across the globe, occurring in parts of present-day North America and South China, coincided very closely with the two peaks in glaciation and extinction. ?But intense bursts of volcanism are more typically linked to massive CO2 release, which should drive global warming, so another process must be responsible for sudden cooling events,? explains Dr Gernon.

This prompted the team to consider whether a secondary process ? natural breakdown or ?weathering? of the volcanic material ? may have provided the surge in phosphorus need to explain the glaciations.

?When volcanic material is deposited in the oceans it undergoes rapid and profound chemical alteration, including release of phosphorus, effectively fertilizing the oceans,? states co-author Professor Martin Palmer from the University of Southampton. ?So, it is seemed viable hypothesis and certainly one worth testing.?

?This led our team to study volcanic ash layers in much younger marine sediments to compare their phosphorus contents before and after they were modified by interactions with seawater? said Dr Hayley Manners, a lecturer in Organic Chemistry at the University of Plymouth. Equipped with this information, the team were better placed to understand the potential geochemical impact of extensive volcanic layers from enormous eruptions during the Ordovician.

?This prompted us to develop a global biogeochemical model to understand the knock-on effects on the carbon cycle of rapidly adding a surge of phosphorus leached from volcanic deposits into the ocean,? says Dr Benjamin Mills, Associate Professor at the University of Leeds and co-author on the study.

The team discovered that widespread blankets of volcanic material laid down on the seafloor during the Ordovician Period would have released sufficient phosphorus into the ocean to drive a chain of events, including climatic cooling, glaciation, widespread reduction in ocean oxygen levels, and mass extinction.

Whilst it might be tempting to think that seeding the oceans with phosphorus may help solve the current climate crisis, the scientists caution that this may have more damaging consequences. ?Excess nutrient runoff from sources like agricultural fertilisers is a major cause of marine eutrophication ? where algae grow rapidly and then decay, consuming oxygen and causing substantial damage to ecosystems at the present day,? cautions Dr Mills.

The scientists conclude that whilst on short timescales massive volcanic eruptions can warm the climate via CO2 emissions, equally they can drive global cooling on multimillion-year timescales. ?Our study may prompt reinvestigations of other mass extinctions during Earth history,? concludes Dr Longman.

We would love to thank the writer of this short article for this remarkable web content

Volcanic fertilization of the oceans drove severe mass extinction

) [summary] => Journal Reference: Jack Longman, Benjamin J. W. Mills, Hayley R. Manners, Thomas M. Gernon & Martin R. Palmer. Late Ordovician climate change and extinctions driven by elevated volcanic nutrient supply. Nature Geoscience, 2021 DOI: 10.1038/s41561-021-00855-5 The researchers, working with colleagues at the University of Oldenburg, the University of Leeds and the University of Plymouth, studied ... Read more [atom_content] =>

Journal Reference:

  1. Jack Longman, Benjamin J. W. Mills, Hayley R. Manners, Thomas M. Gernon & Martin R. Palmer. Late Ordovician climate change and extinctions driven by elevated volcanic nutrient supply. Nature Geoscience, 2021 DOI: 10.1038/s41561-021-00855-5

The researchers, working with colleagues at the University of Oldenburg, the University of Leeds and the University of Plymouth, studied the effects of volcanic ash and lava on ocean chemistry during a period of extreme environmental change around 450 million years ago. Their findings are published in the journal Nature Geoscience.

This period brought about intense planetary cooling, which culminated in a glaciation and the major ?Late Ordovician Mass Extinction?. This extinction led to the loss of about 85% of species dwelling in the oceans, reshaping the course of evolution of life on Earth.

?It?s been suggested that global cooling was driven by an increase in phosphorus input to the oceans? says Dr Jack Longman, lead author of the study based at the University of Oldenburg, and previously a postdoctoral researcher at Southampton. ?Phosphorus is one of the key elements of life, determining the pace at which tiny aquatic organisms like algae can use photosynthesis to convert carbon dioxide (CO2) into organic matter.? These organisms eventually settle to the seabed and are buried, ultimately reducing levels of carbon dioxide in the atmosphere, which then causes cooling.

?The unresolved puzzle is why glaciation and extinction occurred in two distinct phases at this time, separated by about 10 million years,? states Dr Tom Gernon, Associate Professor at the University of Southampton and co-author of the study. ?That requires some mechanism to pulse the supply of phosphorus, which is hard to explain.?

The team identified that two exceptionally large pulses of volcanic activity across the globe, occurring in parts of present-day North America and South China, coincided very closely with the two peaks in glaciation and extinction. ?But intense bursts of volcanism are more typically linked to massive CO2 release, which should drive global warming, so another process must be responsible for sudden cooling events,? explains Dr Gernon.

This prompted the team to consider whether a secondary process ? natural breakdown or ?weathering? of the volcanic material ? may have provided the surge in phosphorus need to explain the glaciations.

?When volcanic material is deposited in the oceans it undergoes rapid and profound chemical alteration, including release of phosphorus, effectively fertilizing the oceans,? states co-author Professor Martin Palmer from the University of Southampton. ?So, it is seemed viable hypothesis and certainly one worth testing.?

?This led our team to study volcanic ash layers in much younger marine sediments to compare their phosphorus contents before and after they were modified by interactions with seawater? said Dr Hayley Manners, a lecturer in Organic Chemistry at the University of Plymouth. Equipped with this information, the team were better placed to understand the potential geochemical impact of extensive volcanic layers from enormous eruptions during the Ordovician.

?This prompted us to develop a global biogeochemical model to understand the knock-on effects on the carbon cycle of rapidly adding a surge of phosphorus leached from volcanic deposits into the ocean,? says Dr Benjamin Mills, Associate Professor at the University of Leeds and co-author on the study.

The team discovered that widespread blankets of volcanic material laid down on the seafloor during the Ordovician Period would have released sufficient phosphorus into the ocean to drive a chain of events, including climatic cooling, glaciation, widespread reduction in ocean oxygen levels, and mass extinction.

Whilst it might be tempting to think that seeding the oceans with phosphorus may help solve the current climate crisis, the scientists caution that this may have more damaging consequences. ?Excess nutrient runoff from sources like agricultural fertilisers is a major cause of marine eutrophication ? where algae grow rapidly and then decay, consuming oxygen and causing substantial damage to ecosystems at the present day,? cautions Dr Mills.

The scientists conclude that whilst on short timescales massive volcanic eruptions can warm the climate via CO2 emissions, equally they can drive global cooling on multimillion-year timescales. ?Our study may prompt reinvestigations of other mass extinctions during Earth history,? concludes Dr Longman.

We would love to thank the writer of this short article for this remarkable web content

Volcanic fertilization of the oceans drove severe mass extinction

[date_timestamp] => 1638484118 ) [3] => Array ( [title] => Machine learning helps mathematicians make new connections [link] => https://redhatbeauty.com/healthandscience/machine-learning-helps-mathematicians-make-new-connections/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 21:11:30 +0000 [category] => Health And ScienceconnectionshelpslearningMachinemathematicians [guid] => https://redhatbeauty.com/?p=7990 [description] => Journal Reference: Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x While computers have long been used to generate data for ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x

While computers have long been used to generate data for mathematicians, the task of identifying interesting patterns has relied mainly on the intuition of the mathematicians themselves. However, it?s now possible to generate more data than any mathematician can reasonably expect to study in a lifetime. Which is where machine learning comes in.

A paper, published today in Nature, describes how DeepMind was set the task of discerning patterns and connections in the fields of knot theory and representation theory. To the surprise of the mathematicians, new connections were suggested; the mathematicians were then able to examine these connections and prove the conjecture suggested by the AI. These results suggest that machine learning can complement mathematical research, guiding intuition about a problem.

Using the patterns identified by machine learning, mathematicians from the University of Oxford discovered a surprising connection between algebraic and geometric invariants of knots, establishing a completely new theorem in the field. The University of Sydney, meanwhile, used the connections made by the AI to bring them close to proving an old conjecture about Kazhdan-Lusztig polynomials, which has been unsolved for 40 years.

Professor Andras Juhasz, of the Mathematical Institute at the University of Oxford and co-author on the paper, said: ?Pure mathematicians work by formulating conjectures and proving these, resulting in theorems. But where do the conjectures come from?

?We have demonstrated that, when guided by mathematical intuition, machine learning provides a powerful framework that can uncover interesting and provable conjectures in areas where a large amount of data is available, or where the objects are too large to study with classical methods.?

Professor Marc Lackeby, of the Mathematical Institute at the University of Oxford and co-author, said: ?It has been fascinating to use machine learning to discover new and unexpected connections between different areas of mathematics. I believe that the work that we have done in Oxford and in Sydney in collaboration with DeepMind demonstrates that machine learning can be a genuinely useful tool in mathematical research.?

Professor Geordie Williamson, Professor of Mathematics at the University of Sydney and director of the Sydney Mathematical Research Institute and co-author, said: ?AI is an extraordinary tool. This work is one of the first times it has demonstrated its usefulness for pure mathematicians, like me.

?Intuition can take us a long way, but AI can help us find connections the human mind might not always easily spot.?

We would love to thank the writer of this post for this outstanding material

Machine learning helps mathematicians make new connections

) [summary] => Journal Reference: Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x While computers have long been used to generate data for ... Read more [atom_content] =>

Journal Reference:

  1. Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x

While computers have long been used to generate data for mathematicians, the task of identifying interesting patterns has relied mainly on the intuition of the mathematicians themselves. However, it?s now possible to generate more data than any mathematician can reasonably expect to study in a lifetime. Which is where machine learning comes in.

A paper, published today in Nature, describes how DeepMind was set the task of discerning patterns and connections in the fields of knot theory and representation theory. To the surprise of the mathematicians, new connections were suggested; the mathematicians were then able to examine these connections and prove the conjecture suggested by the AI. These results suggest that machine learning can complement mathematical research, guiding intuition about a problem.

Using the patterns identified by machine learning, mathematicians from the University of Oxford discovered a surprising connection between algebraic and geometric invariants of knots, establishing a completely new theorem in the field. The University of Sydney, meanwhile, used the connections made by the AI to bring them close to proving an old conjecture about Kazhdan-Lusztig polynomials, which has been unsolved for 40 years.

Professor Andras Juhasz, of the Mathematical Institute at the University of Oxford and co-author on the paper, said: ?Pure mathematicians work by formulating conjectures and proving these, resulting in theorems. But where do the conjectures come from?

?We have demonstrated that, when guided by mathematical intuition, machine learning provides a powerful framework that can uncover interesting and provable conjectures in areas where a large amount of data is available, or where the objects are too large to study with classical methods.?

Professor Marc Lackeby, of the Mathematical Institute at the University of Oxford and co-author, said: ?It has been fascinating to use machine learning to discover new and unexpected connections between different areas of mathematics. I believe that the work that we have done in Oxford and in Sydney in collaboration with DeepMind demonstrates that machine learning can be a genuinely useful tool in mathematical research.?

Professor Geordie Williamson, Professor of Mathematics at the University of Sydney and director of the Sydney Mathematical Research Institute and co-author, said: ?AI is an extraordinary tool. This work is one of the first times it has demonstrated its usefulness for pure mathematicians, like me.

?Intuition can take us a long way, but AI can help us find connections the human mind might not always easily spot.?

We would love to thank the writer of this post for this outstanding material

Machine learning helps mathematicians make new connections

[date_timestamp] => 1638479490 ) [4] => Array ( [title] => Toro show for half an hour, then red in Singo and Empoli comeback [link] => https://redhatbeauty.com/motoring/toro-show-for-half-an-hour-then-red-in-singo-and-empoli-comeback/ [dc] => Array ( [creator] => Debby Kent ) [pubdate] => Thu, 02 Dec 2021 20:21:05 +0000 [category] => MotoringcomebackEmpolihourredSingoToro [guid] => https://redhatbeauty.com/?p=7984 [description] => The goals of Pobega and Pjaca in the first quarter of an hour are not enough for Juric: in 10 the grenades suffer the attacks of the Tuscans, who tear the tie with Romagnoli and La Mantia From our correspondent Mario Pagliara 2 December – TORINO It is the point of regrets, both for Toro ... Read more [content] => Array ( [encoded] =>

The goals of Pobega and Pjaca in the first quarter of an hour are not enough for Juric: in 10 the grenades suffer the attacks of the Tuscans, who tear the tie with Romagnoli and La Mantia

From our correspondent Mario Pagliara

It is the point of regrets, both for Toro and for Empoli. For the grenades because two to zero ahead of the quarter of an hour with Pobega and Pjaca did not manage to win on the evening when Torino celebrates its 115 years. Regrets also for Empoli, with the extra man for seventy minutes: he manages to go upstream with Romagnoli and La Mantia but does not find the knockout blow Game conditioned by the error of the referee Colombo and by Var Mazzoleni: the foul Singo at half an hour was not from direct red.

ONE TWO

?

The signature on the 115th anniversary of Toro is placed at the bottom by Tommaso Pobega. Because after just ten minutes the grenade midfielder presses Zurkowski very high with a devastating force: the result is a rebound that still favors Pobega, skilled in signing the grenade advantage. The evening of the grenade birthday seems to start immediately downhill for Juric’s team, lined up with its traditional 3-4-2-1: in the offensive trident Juric raises Marko Pjaca, missing from the first minute from 12 September against Salernitana. To make up the attacking department are Praet and Sanabria, the latter in place of the injured captain Belotti. All as expected also in Empoli, on the field with a 4-3-2-1 with Di Francesco, Henderson behind Pinamonti. The start of the Bull is overwhelming: if at the tenth minute he already puts his head forward, also at the fourth minute it is necessary to note the bursting descent of a Singo who makes 70 meters ball and chain before concluding (on the side). Pjaca is in the evening and you can guess it after eight minutes when an assist for Sanabria comes out of his shot dirty from Ricci’s back: the Paraguayan hits comfortable with his head but does not frame the goal. Once he takes the lead with Pobega (by the way, he’s on his third goal in the league), it’s time to enjoy the Pjaca-show: in the quarter of an hour, the Croatian seats two Tuscan defenders, before exploding a right perfect round the corner. After fifteen minutes of play Toro 2 Empoli 0. Third goal in Serie A also for Pjaca.

RED A SINGLE

?

If we want to find a fault in this first half of the grenade it is to have thought, probably, that he had already brought home the game too soon. And instead at half an hour comes the episode that reopens everything: Singo lands Di Francesco thrown at the goal. Referee Colombo (a ’90 class whistle, his first run in Serie A) rightly assigns the penalty and a yellow card. At the Var there is the more experienced Mazzoleni who calls him to the monitor, invoking an in-depth analysis to verify if there could be the extremes for a direct red (which is triggered in the case of a clear opportunity from the net). Colombo goes to the video and changes the card: from yellow to direct red. The second decision is wrong. At half an hour Toro therefore in ten men, and four minutes later on the developments of a corner Romagnoli catches the header that reopens the games. Taken the goal, Juric runs for cover: pulls out an excellent Pjaca on the bench, inserting Vojvoda on the right. In the final half, Toro still dances but Milinkovic is careful on Pinamonti (40 ‘).

2-2 LA MANTIA

?

When the recovery begins, a shiver immediately runs on Toro’s back: after just fifty seconds a cross from Di Francesco hits Bremer’s back with the ball caroming Milinkovic’s crossbar. The game rises in tone, becomes nasty: there are different entries of the Empoli defenders at the limits of the regulation, with the young referee Colombo who does not give the feeling of knowing how to control the spirits on the pitch. Aina, Juric and Marchizza pay the price: warned. Despite the man in minus the grenades try to withstand the impact, but slowly the petrol runs out and no supplies arrive from the bench. Yet at 21 ‘Toro devours the blow of the knockout: Bremer opposes Luperto in front of his own area, runs away using the open field and shoots a diagonal that almost ends at the corner. The law of retaliation is relentless: six minutes later, from a perfect cross by Luperto, the head of La Mantia arrives to place the 2-2. Late, Juric makes the changes: Rincon for Praet, Zaza in place of Sanabria. In the end, the Bull suffers but manages to bring home a precious point, albeit full of regrets.

We want to say thanks to the writer of this short article for this remarkable web content

Toro show for half an hour, then red in Singo and Empoli comeback

) [summary] => The goals of Pobega and Pjaca in the first quarter of an hour are not enough for Juric: in 10 the grenades suffer the attacks of the Tuscans, who tear the tie with Romagnoli and La Mantia From our correspondent Mario Pagliara 2 December – TORINO It is the point of regrets, both for Toro ... Read more [atom_content] =>

The goals of Pobega and Pjaca in the first quarter of an hour are not enough for Juric: in 10 the grenades suffer the attacks of the Tuscans, who tear the tie with Romagnoli and La Mantia

From our correspondent Mario Pagliara

It is the point of regrets, both for Toro and for Empoli. For the grenades because two to zero ahead of the quarter of an hour with Pobega and Pjaca did not manage to win on the evening when Torino celebrates its 115 years. Regrets also for Empoli, with the extra man for seventy minutes: he manages to go upstream with Romagnoli and La Mantia but does not find the knockout blow Game conditioned by the error of the referee Colombo and by Var Mazzoleni: the foul Singo at half an hour was not from direct red.

ONE TWO

?

The signature on the 115th anniversary of Toro is placed at the bottom by Tommaso Pobega. Because after just ten minutes the grenade midfielder presses Zurkowski very high with a devastating force: the result is a rebound that still favors Pobega, skilled in signing the grenade advantage. The evening of the grenade birthday seems to start immediately downhill for Juric’s team, lined up with its traditional 3-4-2-1: in the offensive trident Juric raises Marko Pjaca, missing from the first minute from 12 September against Salernitana. To make up the attacking department are Praet and Sanabria, the latter in place of the injured captain Belotti. All as expected also in Empoli, on the field with a 4-3-2-1 with Di Francesco, Henderson behind Pinamonti. The start of the Bull is overwhelming: if at the tenth minute he already puts his head forward, also at the fourth minute it is necessary to note the bursting descent of a Singo who makes 70 meters ball and chain before concluding (on the side). Pjaca is in the evening and you can guess it after eight minutes when an assist for Sanabria comes out of his shot dirty from Ricci’s back: the Paraguayan hits comfortable with his head but does not frame the goal. Once he takes the lead with Pobega (by the way, he’s on his third goal in the league), it’s time to enjoy the Pjaca-show: in the quarter of an hour, the Croatian seats two Tuscan defenders, before exploding a right perfect round the corner. After fifteen minutes of play Toro 2 Empoli 0. Third goal in Serie A also for Pjaca.

RED A SINGLE

?

If we want to find a fault in this first half of the grenade it is to have thought, probably, that he had already brought home the game too soon. And instead at half an hour comes the episode that reopens everything: Singo lands Di Francesco thrown at the goal. Referee Colombo (a ’90 class whistle, his first run in Serie A) rightly assigns the penalty and a yellow card. At the Var there is the more experienced Mazzoleni who calls him to the monitor, invoking an in-depth analysis to verify if there could be the extremes for a direct red (which is triggered in the case of a clear opportunity from the net). Colombo goes to the video and changes the card: from yellow to direct red. The second decision is wrong. At half an hour Toro therefore in ten men, and four minutes later on the developments of a corner Romagnoli catches the header that reopens the games. Taken the goal, Juric runs for cover: pulls out an excellent Pjaca on the bench, inserting Vojvoda on the right. In the final half, Toro still dances but Milinkovic is careful on Pinamonti (40 ‘).

2-2 LA MANTIA

?

When the recovery begins, a shiver immediately runs on Toro’s back: after just fifty seconds a cross from Di Francesco hits Bremer’s back with the ball caroming Milinkovic’s crossbar. The game rises in tone, becomes nasty: there are different entries of the Empoli defenders at the limits of the regulation, with the young referee Colombo who does not give the feeling of knowing how to control the spirits on the pitch. Aina, Juric and Marchizza pay the price: warned. Despite the man in minus the grenades try to withstand the impact, but slowly the petrol runs out and no supplies arrive from the bench. Yet at 21 ‘Toro devours the blow of the knockout: Bremer opposes Luperto in front of his own area, runs away using the open field and shoots a diagonal that almost ends at the corner. The law of retaliation is relentless: six minutes later, from a perfect cross by Luperto, the head of La Mantia arrives to place the 2-2. Late, Juric makes the changes: Rincon for Praet, Zaza in place of Sanabria. In the end, the Bull suffers but manages to bring home a precious point, albeit full of regrets.

We want to say thanks to the writer of this short article for this remarkable web content

Toro show for half an hour, then red in Singo and Empoli comeback

[date_timestamp] => 1638476465 ) [5] => Array ( [title] => Breastfeeding: my history, silicone nipples and lessons learned ? Fashionism [link] => https://redhatbeauty.com/celebrities/breastfeeding-my-history-silicone-nipples-and-lessons-learned-fashionism/ [dc] => Array ( [creator] => River Tents ) [pubdate] => Thu, 02 Dec 2021 20:15:16 +0000 [category] => CelebritiesbreastfeedingFashionismhistorylearnedlessonsnipplessilicone [guid] => https://redhatbeauty.com/?p=7978 [description] => This is probably the most important post I’ve ever written here on the blog. It’s the post that causes me the most emotion. (more than post delivery), memory, pain, struggle. It’s a post about resilience. Talking about breastfeeding is difficult, it is personal, but necessary and important, I wish I had read a report like ... Read more [content] => Array ( [encoded] =>

This is probably the most important post I’ve ever written here on the blog. It’s the post that causes me the most emotion. (more than post delivery), memory, pain, struggle. It’s a post about resilience. Talking about breastfeeding is difficult, it is personal, but necessary and important, I wish I had read a report like this so that I wouldn’t go through what I went through.

First of all, it is necessary to say: information about breastfeeding should be in the basic outfit of any pregnant woman. Talking about the subject consciously – and not romanticized or propertyless – it should be an obligation among public people, influencers, groups of friends, neighbors inside the elevator, in short, it is a subject that needs to be addressed, it cannot be put into perspective and, I don’t know if I’ve already said, it is necessary to be AWARE of the acts and decisions of any mother. NIt’s not about judgment, but about being aware.

That said, I’ll talk about my experience.

I always considered myself an informed pregnant woman, I looked for information, I had 2 meetings with a breastfeeding consultant, I felt, not necessarily prepared, but DELIVERED to the act of breastfeeding for at least 2 years and I can already say: I was completely wrong. I fell into the system that doesn’t care about breastfeeding but works, silently, for this industry and culture of weaning.

Cut to 10/21/2020, Maria Eduarda was born in great health and I felt excited to breastfeed. At first I thought that “feel pain” it was normal, maybe even part of the process in some cases, but it needs to pass and soon. But my question wasn’t about bruises from the wrong catch, but from an outside intervention I didn’t expect. During pregnancy, I was told that ~suddenly my beak could be too flat and that could make it difficult to catch, and apparently that’s what happened.

In the 36 hours that I stayed in the hospital, she took it and took it out, breastfed very little and did not evolve. There were 4, 5, 6 nurses from all shifts and few were able to help evolve with attachment. Duda took it, nursed it, but not too much. Until then that was ok for a newborn and, with all the exams perfect, we headed home.

And that’s when it all really started, armed with Duda and all the information, I tried to breastfeed and nothing? not even a sip. I got in touch with my consultant and her visit in practice (aka with the baby on her lap) it would only be the next day and then something came in that changed my whole relationship with breastfeeding: the intermediate silicone nozzle. She soon recommended using it to breastfeed my daughter, as she was unable to reach the breast.

I, who thought I had all the information possible and was fully aware of the nozzle confusion, didn’t even know what that silicone nozzle was. For a short moment I thought he would be the salvation not only of my breastfeeding, but of my daughter’s FOOD, but I soon saw that he was the big problem that almost reaped an experience I wanted so much to live, since the chances of weaning on his account are high.

After all, what is the silicone tip? It is a thin silicone artifact, almost invisible and with a more protruding nipple with holes to pass the milk. Through the baby’s suction, the milk comes out and ?ready?, it is breastfed without pain and with supposed ease. Sounds amazing, right? But not. It is not natural, it is something improvised and that can end your breastfeeding. I’m talking about it in a radical way because this was the most traumatic and exhausting experience of my life and I wouldn’t want anyone to go through it. The idea is not to scare, but to alert and help mothers not to go through this and, if they are, to seek specialized help.

bico de silicone terror

Back to my 1st day with a silicone nipple, Duda finally took the breast (or would it be the silicone nipple?) and managed to breastfeed “fully”. The next day, at the breastfeeding consultation, there was 1 (one) attempt to breastfeed without the artificial nipple, one and nothing. “And let’s just drop it, Thereza, it’ll be fine”. So, I thought the beak would be something of 1 or 2 days… it came in to stay and, honestly, there was no professional help from the person who introduced it? to take it out. It was for that very reason and I was so lost IN FULL BABY BLUES PUERPERIO PANDEMIC.

With that, days passed and I remained unattended. I tried to take out and nothing, I looked for information and nothing, entered forums, groups and nothing, watched videos and read posts and nothing. I tried to exhaustion and I felt 100% FRUSTRATED, FAILED, DEFEATED, GUILTY. Do you know the most common reports of mothers who suffer from injuries from the wrong attachment? My disease had it, my injury was psychological and wouldn’t heal for anything. Apart from the fact that there were few reports on the subject, I felt like an ET. That’s when my pilgrimage began, seeking to remove the beak:

I hired another breastfeeding consultant and we didn’t get it.

I hired another breastfeeding consultant and, oh, she did it, I breastfed for 3 minutes without a nipple. She left and I couldn’t do it anymore.

I hired a consultant in SP with super experience in the subject, she was great, but the consultation via zoom made it a little difficult in practice, because to teach a more complex grip like this it usually has to be live.

And this all lasted 2 months, a lot of suffocation, fatigue, stress. I gave up, I felt resigned, abstracted, passed, I was dissatisfied, I didn’t want to give up. I even ?could?, but I didn’t want to.

In the meantime, I tried every trick and tutorial I read and nothing. I also spent an absurd amount of money on products that promised to make the beak grow. There were the most diverse types of suckers, from the most basic to the most outrageous, from R$30 to R$300, I tried EVERYTHING. They pulled my chest like a piece of gum, some of them even worked, but the beak ?withered? then, as did my energy to continue in this battle that I didn’t ask to enter.

During this period, Duda even picked up and hitched, but it lasted 2 minutes, 5 minutes, but this was not continuous. Catch and release, euphoria and frustration, a roller coaster of emotions I’ve never felt anything like before.

On this journey, if it wasn’t for Rodrigo, my husband, I would have already given up. Ok, he didn’t do more than his obligation lol, but he didn’t give up for a minute, he supported me all the time and also acted technically to keep her breastfeeding. What does that mean?

At one point, I had EIGHT SILICONES ON my bedside. For what reason? It could be a source of bacteria and contamination for Duda, it needed to be sanitized at each feeding and this was very boring and tiring to do and Rodrigo would do it all the time, day or night, so I would always have a clean beak around, since, BY HURT AND BARRANCOS, we made a free demand.

amamentac?a?o bico de silicone

Another issue that worried me was the fact that she wasn’t gaining much weight, she grew, but at the limit. We didn’t get to the point of introducing a formula, but that was a fear I had, as it could lead to weaning. The question is that with the artificial nipple you can’t know how much milk is coming out and, most importantly, the baby’s grip and sucking power are not the same, so Less milk comes out, production gradually decreases, which leads to weaning.

And everywhere I read, that was the consequence, you could be able to breastfeed for 1 month, 3 months, there was even that cousin of a friend who breastfed for 6 months with a silicone nipple, but in this case, there is no way to personalize stories, the call always led to weaning.

And I wanted to breastfeed, I really wanted to breastfeed, pure and freely, without nipples, nor crying, nor candles. I wanted to get my chest out of my clothes at any time, take my daughter in my arms and breastfeed without any intervention, without any intermediary.

amamentac?a?o consultora rj

And with a lot of struggle, crying, suffering, giving up and resilience, day December 18, Maria Eduarda with 57 days, I got a last minute consultation with an expert in Consultancy in Breastfeeding and who understood a lot about this ~universe of removal of such a silicone nipple. THE Bianca Balassiano was an angel that fell into my life – and met after tireless searches on Instagram ? and, in just one consultation, a PROPER HANDLING TECHNIQUE that I had never done (and that involved my beak type and even my breast size) and that’s it, Maria Eduarda engaged in the feeding and never let go until today at that exact moment (yes, during this huge post I stopped for her to nurse lol).

I thought that, as had happened the other time, when I was breastfeeding at home without assistance, I would not be able to? BUT NOTHING, I arrived home FULL OF FEAR, AFFLICTED, ANXIOUS and danada took it and suckled and suckled and suckled and suckled until today, 1 year, 1 month and 10 days of very free demand, highs, lows, silicone and skin, a lot of skin. It’s tiring, it’s exhausting, sometimes I hide in the bathroom for 15 minutes, I cry, laugh, she pinches me, bites me, breasts one, radio-teas another, but it’s also good, it’s pure, it’s essential for her, is important to me.

I had expectations about breastfeeding, but I didn’t imagine it would be this deep and intense. I think that my extremely negative experience showed me the strength and desire to breastfeed that I didn’t even know I had.

amamentac?a?o the duda

Now it is important to mention a few points: the silicone nipple has been highly recommended by professionals, whether breastfeeding or in the hospital itself and, make no mistake, it may even seem practical and comfortable, BUT IT IS NOT. In the medium term it is not. Do you want to breastfeed for a long time? That nipple is half the way to weaning, yes. Look for responsible professionals who do not romanticize or trivialize the product.

Generally (ok, 99% of the time) who recommends the beak is because they lack knowledge or, mainly, PATIENCE to reach the correct grip and it exists and is totally possible. It may take time, but it’s the right way and not the tip.

Now, if a professional in the area recommended the beak and for some reason you REALLY need it: it’s her duty to lead you to the removal at the right time. Instruct you until the end for you to pass this stage.

I spent very many reais with FOUR other consultants and DOZENS of contraptions to get rid of the bill, but if I had had this driving from the beginning, I could have gone through it all, but in a faster and less traumatic way. Remembering that I experienced this at the height of the pandemic, which makes everything more difficult.

The Flat Nipple Matter (or even inverted ones) it can even be a complicating factor for breastfeeding, but it will not stop you from breastfeeding, but it will probably need more time, patience and instruction for proper attachment., She exists. Then I found out that mine wasn’t even flat, but a little protruding, but today it’s a little bottle #intimacy lol.

I know that many mothers are using the silicone nipple ? which is also called a nipple protector, to protect from bruises from the first days of getting caught. Then I say: choose your battles. The wound is a terrible pain, I’ve been experiencing it more now because the lady here has a habit of biting, but silicone is a more long-term problem and it’s difficult to solve. So understand that the protection that the beak is supposed to give (not always right, because he’s also there rubbing the wound), causes worse problems to arise.

amamentac?a?o bico silicone

Finally, as I said at the beginning, breastfeeding is information and awareness. Whether it’s time to accept the silicone nipple or consciously opt for pacifiers and bottles, we know that nipple confusion is a reality and that it is a major cause of weaning. Are you aware of this? Okay. Did you look for the right information and that goes with your ideas and even your lifestyle? Go ahead.

Now what usually surrounds us, and must be fought, is this c.ulture that insists on misinforming, confusing and interfering with something as important as breastfeeding. It’s not about judging mothers and their choices, but about questioning this industry that leads to weaning, identifying those responsible and, most importantly, welcome mothers who are in this battle and learning.

amamentac?a?o scaled

As an influencer, I’ve already made mistakes and learned about this universe of motherhood and now I do the least sharing my story and trying to help other mothers to have a calmer mother! May this post of mine help other women and, if you know other pregnant women, share this content!

We want to say thanks to the author of this write-up for this outstanding web content

Breastfeeding: my history, silicone nipples and lessons learned – Fashionism

) [summary] => This is probably the most important post I’ve ever written here on the blog. It’s the post that causes me the most emotion. (more than post delivery), memory, pain, struggle. It’s a post about resilience. Talking about breastfeeding is difficult, it is personal, but necessary and important, I wish I had read a report like ... Read more [atom_content] =>

This is probably the most important post I’ve ever written here on the blog. It’s the post that causes me the most emotion. (more than post delivery), memory, pain, struggle. It’s a post about resilience. Talking about breastfeeding is difficult, it is personal, but necessary and important, I wish I had read a report like this so that I wouldn’t go through what I went through.

First of all, it is necessary to say: information about breastfeeding should be in the basic outfit of any pregnant woman. Talking about the subject consciously – and not romanticized or propertyless – it should be an obligation among public people, influencers, groups of friends, neighbors inside the elevator, in short, it is a subject that needs to be addressed, it cannot be put into perspective and, I don’t know if I’ve already said, it is necessary to be AWARE of the acts and decisions of any mother. NIt’s not about judgment, but about being aware.

That said, I’ll talk about my experience.

I always considered myself an informed pregnant woman, I looked for information, I had 2 meetings with a breastfeeding consultant, I felt, not necessarily prepared, but DELIVERED to the act of breastfeeding for at least 2 years and I can already say: I was completely wrong. I fell into the system that doesn’t care about breastfeeding but works, silently, for this industry and culture of weaning.

Cut to 10/21/2020, Maria Eduarda was born in great health and I felt excited to breastfeed. At first I thought that “feel pain” it was normal, maybe even part of the process in some cases, but it needs to pass and soon. But my question wasn’t about bruises from the wrong catch, but from an outside intervention I didn’t expect. During pregnancy, I was told that ~suddenly my beak could be too flat and that could make it difficult to catch, and apparently that’s what happened.

In the 36 hours that I stayed in the hospital, she took it and took it out, breastfed very little and did not evolve. There were 4, 5, 6 nurses from all shifts and few were able to help evolve with attachment. Duda took it, nursed it, but not too much. Until then that was ok for a newborn and, with all the exams perfect, we headed home.

And that’s when it all really started, armed with Duda and all the information, I tried to breastfeed and nothing? not even a sip. I got in touch with my consultant and her visit in practice (aka with the baby on her lap) it would only be the next day and then something came in that changed my whole relationship with breastfeeding: the intermediate silicone nozzle. She soon recommended using it to breastfeed my daughter, as she was unable to reach the breast.

I, who thought I had all the information possible and was fully aware of the nozzle confusion, didn’t even know what that silicone nozzle was. For a short moment I thought he would be the salvation not only of my breastfeeding, but of my daughter’s FOOD, but I soon saw that he was the big problem that almost reaped an experience I wanted so much to live, since the chances of weaning on his account are high.

After all, what is the silicone tip? It is a thin silicone artifact, almost invisible and with a more protruding nipple with holes to pass the milk. Through the baby’s suction, the milk comes out and ?ready?, it is breastfed without pain and with supposed ease. Sounds amazing, right? But not. It is not natural, it is something improvised and that can end your breastfeeding. I’m talking about it in a radical way because this was the most traumatic and exhausting experience of my life and I wouldn’t want anyone to go through it. The idea is not to scare, but to alert and help mothers not to go through this and, if they are, to seek specialized help.

bico de silicone terror

Back to my 1st day with a silicone nipple, Duda finally took the breast (or would it be the silicone nipple?) and managed to breastfeed “fully”. The next day, at the breastfeeding consultation, there was 1 (one) attempt to breastfeed without the artificial nipple, one and nothing. “And let’s just drop it, Thereza, it’ll be fine”. So, I thought the beak would be something of 1 or 2 days… it came in to stay and, honestly, there was no professional help from the person who introduced it? to take it out. It was for that very reason and I was so lost IN FULL BABY BLUES PUERPERIO PANDEMIC.

With that, days passed and I remained unattended. I tried to take out and nothing, I looked for information and nothing, entered forums, groups and nothing, watched videos and read posts and nothing. I tried to exhaustion and I felt 100% FRUSTRATED, FAILED, DEFEATED, GUILTY. Do you know the most common reports of mothers who suffer from injuries from the wrong attachment? My disease had it, my injury was psychological and wouldn’t heal for anything. Apart from the fact that there were few reports on the subject, I felt like an ET. That’s when my pilgrimage began, seeking to remove the beak:

I hired another breastfeeding consultant and we didn’t get it.

I hired another breastfeeding consultant and, oh, she did it, I breastfed for 3 minutes without a nipple. She left and I couldn’t do it anymore.

I hired a consultant in SP with super experience in the subject, she was great, but the consultation via zoom made it a little difficult in practice, because to teach a more complex grip like this it usually has to be live.

And this all lasted 2 months, a lot of suffocation, fatigue, stress. I gave up, I felt resigned, abstracted, passed, I was dissatisfied, I didn’t want to give up. I even ?could?, but I didn’t want to.

In the meantime, I tried every trick and tutorial I read and nothing. I also spent an absurd amount of money on products that promised to make the beak grow. There were the most diverse types of suckers, from the most basic to the most outrageous, from R$30 to R$300, I tried EVERYTHING. They pulled my chest like a piece of gum, some of them even worked, but the beak ?withered? then, as did my energy to continue in this battle that I didn’t ask to enter.

During this period, Duda even picked up and hitched, but it lasted 2 minutes, 5 minutes, but this was not continuous. Catch and release, euphoria and frustration, a roller coaster of emotions I’ve never felt anything like before.

On this journey, if it wasn’t for Rodrigo, my husband, I would have already given up. Ok, he didn’t do more than his obligation lol, but he didn’t give up for a minute, he supported me all the time and also acted technically to keep her breastfeeding. What does that mean?

At one point, I had EIGHT SILICONES ON my bedside. For what reason? It could be a source of bacteria and contamination for Duda, it needed to be sanitized at each feeding and this was very boring and tiring to do and Rodrigo would do it all the time, day or night, so I would always have a clean beak around, since, BY HURT AND BARRANCOS, we made a free demand.

amamentac?a?o bico de silicone

Another issue that worried me was the fact that she wasn’t gaining much weight, she grew, but at the limit. We didn’t get to the point of introducing a formula, but that was a fear I had, as it could lead to weaning. The question is that with the artificial nipple you can’t know how much milk is coming out and, most importantly, the baby’s grip and sucking power are not the same, so Less milk comes out, production gradually decreases, which leads to weaning.

And everywhere I read, that was the consequence, you could be able to breastfeed for 1 month, 3 months, there was even that cousin of a friend who breastfed for 6 months with a silicone nipple, but in this case, there is no way to personalize stories, the call always led to weaning.

And I wanted to breastfeed, I really wanted to breastfeed, pure and freely, without nipples, nor crying, nor candles. I wanted to get my chest out of my clothes at any time, take my daughter in my arms and breastfeed without any intervention, without any intermediary.

amamentac?a?o consultora rj

And with a lot of struggle, crying, suffering, giving up and resilience, day December 18, Maria Eduarda with 57 days, I got a last minute consultation with an expert in Consultancy in Breastfeeding and who understood a lot about this ~universe of removal of such a silicone nipple. THE Bianca Balassiano was an angel that fell into my life – and met after tireless searches on Instagram ? and, in just one consultation, a PROPER HANDLING TECHNIQUE that I had never done (and that involved my beak type and even my breast size) and that’s it, Maria Eduarda engaged in the feeding and never let go until today at that exact moment (yes, during this huge post I stopped for her to nurse lol).

I thought that, as had happened the other time, when I was breastfeeding at home without assistance, I would not be able to? BUT NOTHING, I arrived home FULL OF FEAR, AFFLICTED, ANXIOUS and danada took it and suckled and suckled and suckled and suckled until today, 1 year, 1 month and 10 days of very free demand, highs, lows, silicone and skin, a lot of skin. It’s tiring, it’s exhausting, sometimes I hide in the bathroom for 15 minutes, I cry, laugh, she pinches me, bites me, breasts one, radio-teas another, but it’s also good, it’s pure, it’s essential for her, is important to me.

I had expectations about breastfeeding, but I didn’t imagine it would be this deep and intense. I think that my extremely negative experience showed me the strength and desire to breastfeed that I didn’t even know I had.

amamentac?a?o the duda

Now it is important to mention a few points: the silicone nipple has been highly recommended by professionals, whether breastfeeding or in the hospital itself and, make no mistake, it may even seem practical and comfortable, BUT IT IS NOT. In the medium term it is not. Do you want to breastfeed for a long time? That nipple is half the way to weaning, yes. Look for responsible professionals who do not romanticize or trivialize the product.

Generally (ok, 99% of the time) who recommends the beak is because they lack knowledge or, mainly, PATIENCE to reach the correct grip and it exists and is totally possible. It may take time, but it’s the right way and not the tip.

Now, if a professional in the area recommended the beak and for some reason you REALLY need it: it’s her duty to lead you to the removal at the right time. Instruct you until the end for you to pass this stage.

I spent very many reais with FOUR other consultants and DOZENS of contraptions to get rid of the bill, but if I had had this driving from the beginning, I could have gone through it all, but in a faster and less traumatic way. Remembering that I experienced this at the height of the pandemic, which makes everything more difficult.

The Flat Nipple Matter (or even inverted ones) it can even be a complicating factor for breastfeeding, but it will not stop you from breastfeeding, but it will probably need more time, patience and instruction for proper attachment., She exists. Then I found out that mine wasn’t even flat, but a little protruding, but today it’s a little bottle #intimacy lol.

I know that many mothers are using the silicone nipple ? which is also called a nipple protector, to protect from bruises from the first days of getting caught. Then I say: choose your battles. The wound is a terrible pain, I’ve been experiencing it more now because the lady here has a habit of biting, but silicone is a more long-term problem and it’s difficult to solve. So understand that the protection that the beak is supposed to give (not always right, because he’s also there rubbing the wound), causes worse problems to arise.

amamentac?a?o bico silicone

Finally, as I said at the beginning, breastfeeding is information and awareness. Whether it’s time to accept the silicone nipple or consciously opt for pacifiers and bottles, we know that nipple confusion is a reality and that it is a major cause of weaning. Are you aware of this? Okay. Did you look for the right information and that goes with your ideas and even your lifestyle? Go ahead.

Now what usually surrounds us, and must be fought, is this c.ulture that insists on misinforming, confusing and interfering with something as important as breastfeeding. It’s not about judging mothers and their choices, but about questioning this industry that leads to weaning, identifying those responsible and, most importantly, welcome mothers who are in this battle and learning.

amamentac?a?o scaled

As an influencer, I’ve already made mistakes and learned about this universe of motherhood and now I do the least sharing my story and trying to help other mothers to have a calmer mother! May this post of mine help other women and, if you know other pregnant women, share this content!

We want to say thanks to the author of this write-up for this outstanding web content

Breastfeeding: my history, silicone nipples and lessons learned – Fashionism

[date_timestamp] => 1638476116 ) [6] => Array ( [title] => One of the most important Final Fantasy, and its role in Endwalker [link] => https://redhatbeauty.com/sport/one-of-the-most-important-final-fantasy-and-its-role-in-endwalker/ [dc] => Array ( [creator] => Toby Peters ) [pubdate] => Thu, 02 Dec 2021 20:14:16 +0000 [category] => SportEndwalkerFantasyfinalrole [guid] => https://redhatbeauty.com/?p=7972 [description] => Final Fantasy IV will play a fundamental role in the story of Final Fantasy XIV, not only in secondary aspects such as mounts and minions. Here because. To prepare you worthily for the new chapter in the history of Final Fantasy XIV, it’s worth taking a look at Endwalker’s references to Final Fantasy IV, which, ... Read more [content] => Array ( [encoded] =>

Final Fantasy IV will play a fundamental role in the story of Final Fantasy XIV, not only in secondary aspects such as mounts and minions. Here because.

To prepare you worthily for the new chapter in the history of Final Fantasy XIV, it’s worth taking a look at Endwalker’s references to Final Fantasy IV, which, you’ll soon find out, go far beyond mounts and minions. A few days after the release of Final Fantasy XIV: Endwalker, it’s time to get ready for all the news coming: finish the main story quests and level up your side jobs, first of all. Not only that, though: it’s also time to fortify your knowledge of FFIV, so that you can deepen the story by grasping every aspect. To help you on this journey, here’s an explanation of the more explicit elements taken from Final Fantasy IV, as well as the story passages the two games have in common.

Add 4 to 14 –

Although Endwalker isn’t out yet, you can see FFIV influences all over the place. Towards the end of Shadowbringers, the previous expansion, the development team began this process of implementing Lunar Bahamut. Fandaniel, an ascian who wants to kill lots of people and destroy the world of Eorzea, summons an altered version of many primals, including il Lunar Bahamut. This creature is only an optional boss in FFIV, but the Lunar Bahamut has created a connection between that game and FFXIV, at the same time indicating that the Moon will play an important role in the story from here on out.

The connection between the two games was confirmed at the FFXIV Fan Festival, when the trailer for Endwalker was unveiled. Square Enix also announced new items for the Mogstation shop: three new minions and a new mount, all originally part of the main FFIV story.

The three minions are based on the main cast of characters from FFIV. You can buy Rosa for your collection: she is a childhood friend of the main character, Cecil. There’s also Edge, an edgy ninja and prince of Eblan. The third character you can have with you is a miniaturized version of Rydia. As a young man, Rydia met Cecil after he and his friend Kain attacked her village and killed her mother, defeating the eidolon she had summoned. Eventually, she finds herself following Cecil and her party. During their journey, however, she falls into the ocean and is taken from Leviathan to Feymarch, where time passes faster. When she reunites with Cecil and the others, she is already a young woman and a powerful summoner.

As if that weren’t enough, having these three important characters reunited with the Warrior of Light in Eorzea, players can also fly in their next adventure in full FFIV style. The Lunar Whale eight-player mount It may attract a lot of attention due to its size and price, but it’s also an integral part of the FFIV story. Once they discover the truth about what is happening, the characters must leave for the moon. To do this, they have to use a strange whale-shaped spaceship.

Other FFIV-inspired elements were teased in the latest Live Letter, which unveiled the tomestone gear sets. In FFXIV, these sets can be bought using tomestone, a specific currency that is acquired by completing various tasks. They are an important part of a player’s routine, as they usually need to be used to get the best pieces of gear that can be obtained with a new patch. New sets have been introduced at the beginning and during the life cycle of the new expansions, and that won’t change with Endwalker. Some of the new pieces of equipment have been shown since producer e director Naoki Yoshida, and among them are some based on the main characters of FFIV. For example, tank players will be able to purchase Cecil’s armor, ninjas will be able to use Edge’s, and Rydia’s outfit will likely be suited to summoners. The connections go beyond the aesthetic aspects, however. Cecil’s story is the heart of Endwalker.

The end of a journey –

Ever since it came out, Final Fantasy XIV has always been a playground for fans of the series. There have been tons of crossovers with other titles in the saga but choosing FFIV for this specific moment in the game’s history it’s really symbolic by the development team.

SS 04

Upon the announcement of Endwalker, Naoki Yoshida explained that it would be the last expansion that would cover the story that began with A Realm Reborn. His statement was misunderstood and many thought it would be the end of the game, but this chapter is meant only to close the story of the conflict between the two entities involved in the main narrative so far: Hydaelyn e Zodiark. After that, the game will take new directions, immersing fans in different stories.

New stories, changes, perspectives and the idea of ??transition are key parts of both FFIV and FFXIV. In each expansion of FFXIV, the protagonist acquires new jobs (the classes of this MMO). In Shadowbringers, you start out as a knight. In the Endwalker trailer, the Warrior of Light appears, walking on the moon and wearing the glittering metal armor of a paladin complete with a sword and shield. This same change happens to the protagonist of FFIV, Cecil. At the beginning of the game, Cecil is a dark knight who works as the captain of an airship called Red Wings. During his journey, after defeating his demons, he transforms into a paladin.

Final Fantasy XIV influenced by FFIV: how and why

The transformation Cecil arrives when he discovers that his father was a Lunarian, a member of the advanced civilization hibernating on the Moon. Changing his job (i.e. class) symbolizes his inner transformation as a person. This gives players a lot to think about what we might see in Endwalker. In Shadowbringers, it is shown that even Hydaelyn is not purity embodied as previously thought and that too much light can hurt a world that should aim for balance. The main story implies that the main character’s spirit may have come from the original Ascians, another little piece of information that ends up relativizing the world as known until then. Will players uncover the truth behind the Warrior of Light’s origins? Is something fundamental about to change in the protagonist?

It’s unclear if the new expansion will delve into these themes, but it would make sense if the story pointed to reflect that of FFIV. The expectations are huge for Endwalker, considering the position that Final Fantasy XIV occupies today – that is, that of one of the best Final Fantasy ever made. Whether or not it respects these expectations, it is not yet known. But, considering what has already been shown to the public and all the possibilities that FFIV opens up to the Endwalker narrative, it is clear how much the development team is striving to create a memorable experience for fans of the saga.

Written by Paulo Kawanishi for GLHF

We would like to give thanks to the writer of this post for this incredible material

One of the most important Final Fantasy, and its role in Endwalker

) [summary] => Final Fantasy IV will play a fundamental role in the story of Final Fantasy XIV, not only in secondary aspects such as mounts and minions. Here because. To prepare you worthily for the new chapter in the history of Final Fantasy XIV, it’s worth taking a look at Endwalker’s references to Final Fantasy IV, which, ... Read more [atom_content] =>

Final Fantasy IV will play a fundamental role in the story of Final Fantasy XIV, not only in secondary aspects such as mounts and minions. Here because.

To prepare you worthily for the new chapter in the history of Final Fantasy XIV, it’s worth taking a look at Endwalker’s references to Final Fantasy IV, which, you’ll soon find out, go far beyond mounts and minions. A few days after the release of Final Fantasy XIV: Endwalker, it’s time to get ready for all the news coming: finish the main story quests and level up your side jobs, first of all. Not only that, though: it’s also time to fortify your knowledge of FFIV, so that you can deepen the story by grasping every aspect. To help you on this journey, here’s an explanation of the more explicit elements taken from Final Fantasy IV, as well as the story passages the two games have in common.

Add 4 to 14 –

Although Endwalker isn’t out yet, you can see FFIV influences all over the place. Towards the end of Shadowbringers, the previous expansion, the development team began this process of implementing Lunar Bahamut. Fandaniel, an ascian who wants to kill lots of people and destroy the world of Eorzea, summons an altered version of many primals, including il Lunar Bahamut. This creature is only an optional boss in FFIV, but the Lunar Bahamut has created a connection between that game and FFXIV, at the same time indicating that the Moon will play an important role in the story from here on out.

The connection between the two games was confirmed at the FFXIV Fan Festival, when the trailer for Endwalker was unveiled. Square Enix also announced new items for the Mogstation shop: three new minions and a new mount, all originally part of the main FFIV story.

The three minions are based on the main cast of characters from FFIV. You can buy Rosa for your collection: she is a childhood friend of the main character, Cecil. There’s also Edge, an edgy ninja and prince of Eblan. The third character you can have with you is a miniaturized version of Rydia. As a young man, Rydia met Cecil after he and his friend Kain attacked her village and killed her mother, defeating the eidolon she had summoned. Eventually, she finds herself following Cecil and her party. During their journey, however, she falls into the ocean and is taken from Leviathan to Feymarch, where time passes faster. When she reunites with Cecil and the others, she is already a young woman and a powerful summoner.

As if that weren’t enough, having these three important characters reunited with the Warrior of Light in Eorzea, players can also fly in their next adventure in full FFIV style. The Lunar Whale eight-player mount It may attract a lot of attention due to its size and price, but it’s also an integral part of the FFIV story. Once they discover the truth about what is happening, the characters must leave for the moon. To do this, they have to use a strange whale-shaped spaceship.

Other FFIV-inspired elements were teased in the latest Live Letter, which unveiled the tomestone gear sets. In FFXIV, these sets can be bought using tomestone, a specific currency that is acquired by completing various tasks. They are an important part of a player’s routine, as they usually need to be used to get the best pieces of gear that can be obtained with a new patch. New sets have been introduced at the beginning and during the life cycle of the new expansions, and that won’t change with Endwalker. Some of the new pieces of equipment have been shown since producer e director Naoki Yoshida, and among them are some based on the main characters of FFIV. For example, tank players will be able to purchase Cecil’s armor, ninjas will be able to use Edge’s, and Rydia’s outfit will likely be suited to summoners. The connections go beyond the aesthetic aspects, however. Cecil’s story is the heart of Endwalker.

The end of a journey –

Ever since it came out, Final Fantasy XIV has always been a playground for fans of the series. There have been tons of crossovers with other titles in the saga but choosing FFIV for this specific moment in the game’s history it’s really symbolic by the development team.

SS 04

Upon the announcement of Endwalker, Naoki Yoshida explained that it would be the last expansion that would cover the story that began with A Realm Reborn. His statement was misunderstood and many thought it would be the end of the game, but this chapter is meant only to close the story of the conflict between the two entities involved in the main narrative so far: Hydaelyn e Zodiark. After that, the game will take new directions, immersing fans in different stories.

New stories, changes, perspectives and the idea of ??transition are key parts of both FFIV and FFXIV. In each expansion of FFXIV, the protagonist acquires new jobs (the classes of this MMO). In Shadowbringers, you start out as a knight. In the Endwalker trailer, the Warrior of Light appears, walking on the moon and wearing the glittering metal armor of a paladin complete with a sword and shield. This same change happens to the protagonist of FFIV, Cecil. At the beginning of the game, Cecil is a dark knight who works as the captain of an airship called Red Wings. During his journey, after defeating his demons, he transforms into a paladin.

Final Fantasy XIV influenced by FFIV: how and why

The transformation Cecil arrives when he discovers that his father was a Lunarian, a member of the advanced civilization hibernating on the Moon. Changing his job (i.e. class) symbolizes his inner transformation as a person. This gives players a lot to think about what we might see in Endwalker. In Shadowbringers, it is shown that even Hydaelyn is not purity embodied as previously thought and that too much light can hurt a world that should aim for balance. The main story implies that the main character’s spirit may have come from the original Ascians, another little piece of information that ends up relativizing the world as known until then. Will players uncover the truth behind the Warrior of Light’s origins? Is something fundamental about to change in the protagonist?

It’s unclear if the new expansion will delve into these themes, but it would make sense if the story pointed to reflect that of FFIV. The expectations are huge for Endwalker, considering the position that Final Fantasy XIV occupies today – that is, that of one of the best Final Fantasy ever made. Whether or not it respects these expectations, it is not yet known. But, considering what has already been shown to the public and all the possibilities that FFIV opens up to the Endwalker narrative, it is clear how much the development team is striving to create a memorable experience for fans of the saga.

Written by Paulo Kawanishi for GLHF

We would like to give thanks to the writer of this post for this incredible material

One of the most important Final Fantasy, and its role in Endwalker

[date_timestamp] => 1638476056 ) [7] => Array ( [title] => Targeting the brain?s immune cells may help prevent or treat Alzheimer?s disease [link] => https://redhatbeauty.com/healthandscience/targeting-the-brains-immune-cells-may-help-prevent-or-treat-alzheimers-disease/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 19:54:27 +0000 [category] => Health And ScienceAlzheimersbrainscellsdiseaseimmunepreventTargetingtreat [guid] => https://redhatbeauty.com/?p=7967 [description] => Journal Reference: Faten A. Sayed, Lay Kodama, Li Fan, Gillian K. Carling, Joe C. Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew Brendel, Maria Telpoukhovskaia, Tara E. Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Faten A. Sayed, Lay Kodama, Li Fan, Gillian K. Carling, Joe C. Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew Brendel, Maria Telpoukhovskaia, Tara E. Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, Yue Qiu, Zuolin Cheng, Guoqiang Yu, John Hardy, Giovanni Coppola, Fei Wang, Michael A. DeTure, Bin Zhang, Lei Xie, John Q. Trajnowski, Virginia M. Y. Lee, Shiaoching Gong, Subhash C. Sinha, Dennis W. Dickson, Wenjie Luo, Li Gan. AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science Translational Medicine, 2021; 13 (622) DOI: 10.1126/scitranslmed.abe3947

The study, published Dec. 1 in Science Translational Medicine, focused on microglia, immune cells of the central nervous system that are the first to respond when something goes wrong in the brain. Studies have identified many genetic variants linked to Alzheimer?s disease that are highly expressed in microglia, providing compelling evidence that alterations within these cells may play a role in the disease?s onset and progression.

?Microglia are guardians of the brain under healthy conditions, but can turn detrimental in disease conditions. Our goal is to identify how they become toxic and contribute to Alzheimer?s disease pathogenesis and whether we can identify immune modulators to reverse the toxicity without diminishing their normal protective function,? said senior author Dr. Li Gan, director of the Helen and Robert Appel Alzheimer?s Disease Research Institute and the Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine.

Alzheimer?s disease is the most prevalent neurodegenerative disease in ageing, affecting approximately 46 million people worldwide. Theories point to a number of potential causes, including age-related changes in the brain, along with genetic, environmental, and lifestyle factors. These lead to the accumulation of toxic proteins in the brain ? and according to recent evidence, immune system changes ? that result in loss of neurons and their connections.

To examine how the brain?s immune cells may contribute to Alzheimer?s disease, Dr. Gan and her colleagues first established the molecule fingerprint of individual microglia in the brains of patients with Alzheimer?s disease who carry a mutation in the TREM2 gene that markedly elevates individual?s risk for developing Alzheimer?s disease. TREM2 is a receptor mainly expressed by microglia in the brain, and among other functions, it signals through an enzyme named AKT to modulate inflammation and metabolism.

The team then established a mouse model by combining two strains; one that carries the AD-linked mutation in the TREM2 gene and another that exhibits Tau aggregates, one of the major pathological hallmarks in Alzheimer brains. Both patients and mice with the mutation demonstrated memory-related deficits, and their microglia expressed high levels of inflammatory molecules and exhibited an overactive AKT signaling pathway. In the mice, inhibiting AKT with a drug called MK-2206 reversed the inflammatory properties of microglia and protected against synaptic toxicity ? a type of damage to the brain?s neurons that is a hallmark of Alzheimer?s disease.

Importantly, because AKT signaling also contributes to the pathogenesis of many types of cancer, MK-2206 is currently being evaluated in multiple cancer clinical trials. Therefore, the safety of the drug is already under investigation.

?We identified a small molecule compound that has been tested in patients with cancer, readily enters the brain, potently modulates the brain?s immune responses, and protects against synaptic loss in animal models of Alzheimer?s disease,? Dr. Gan said. ?Our findings support further study of this compound as a potential therapy for Alzheimer?s disease.?

Dr. Li Gan is a co-founder with equity and consultant for Aeton Therapeutics, Inc.

We want to say thanks to the author of this write-up for this incredible web content

Targeting the brain?s immune cells may help prevent or treat Alzheimer?s disease

) [summary] => Journal Reference: Faten A. Sayed, Lay Kodama, Li Fan, Gillian K. Carling, Joe C. Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew Brendel, Maria Telpoukhovskaia, Tara E. Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, ... Read more [atom_content] =>

Journal Reference:

  1. Faten A. Sayed, Lay Kodama, Li Fan, Gillian K. Carling, Joe C. Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew Brendel, Maria Telpoukhovskaia, Tara E. Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, Yue Qiu, Zuolin Cheng, Guoqiang Yu, John Hardy, Giovanni Coppola, Fei Wang, Michael A. DeTure, Bin Zhang, Lei Xie, John Q. Trajnowski, Virginia M. Y. Lee, Shiaoching Gong, Subhash C. Sinha, Dennis W. Dickson, Wenjie Luo, Li Gan. AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science Translational Medicine, 2021; 13 (622) DOI: 10.1126/scitranslmed.abe3947

The study, published Dec. 1 in Science Translational Medicine, focused on microglia, immune cells of the central nervous system that are the first to respond when something goes wrong in the brain. Studies have identified many genetic variants linked to Alzheimer?s disease that are highly expressed in microglia, providing compelling evidence that alterations within these cells may play a role in the disease?s onset and progression.

?Microglia are guardians of the brain under healthy conditions, but can turn detrimental in disease conditions. Our goal is to identify how they become toxic and contribute to Alzheimer?s disease pathogenesis and whether we can identify immune modulators to reverse the toxicity without diminishing their normal protective function,? said senior author Dr. Li Gan, director of the Helen and Robert Appel Alzheimer?s Disease Research Institute and the Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine.

Alzheimer?s disease is the most prevalent neurodegenerative disease in ageing, affecting approximately 46 million people worldwide. Theories point to a number of potential causes, including age-related changes in the brain, along with genetic, environmental, and lifestyle factors. These lead to the accumulation of toxic proteins in the brain ? and according to recent evidence, immune system changes ? that result in loss of neurons and their connections.

To examine how the brain?s immune cells may contribute to Alzheimer?s disease, Dr. Gan and her colleagues first established the molecule fingerprint of individual microglia in the brains of patients with Alzheimer?s disease who carry a mutation in the TREM2 gene that markedly elevates individual?s risk for developing Alzheimer?s disease. TREM2 is a receptor mainly expressed by microglia in the brain, and among other functions, it signals through an enzyme named AKT to modulate inflammation and metabolism.

The team then established a mouse model by combining two strains; one that carries the AD-linked mutation in the TREM2 gene and another that exhibits Tau aggregates, one of the major pathological hallmarks in Alzheimer brains. Both patients and mice with the mutation demonstrated memory-related deficits, and their microglia expressed high levels of inflammatory molecules and exhibited an overactive AKT signaling pathway. In the mice, inhibiting AKT with a drug called MK-2206 reversed the inflammatory properties of microglia and protected against synaptic toxicity ? a type of damage to the brain?s neurons that is a hallmark of Alzheimer?s disease.

Importantly, because AKT signaling also contributes to the pathogenesis of many types of cancer, MK-2206 is currently being evaluated in multiple cancer clinical trials. Therefore, the safety of the drug is already under investigation.

?We identified a small molecule compound that has been tested in patients with cancer, readily enters the brain, potently modulates the brain?s immune responses, and protects against synaptic loss in animal models of Alzheimer?s disease,? Dr. Gan said. ?Our findings support further study of this compound as a potential therapy for Alzheimer?s disease.?

Dr. Li Gan is a co-founder with equity and consultant for Aeton Therapeutics, Inc.

We want to say thanks to the author of this write-up for this incredible web content

Targeting the brain?s immune cells may help prevent or treat Alzheimer?s disease

[date_timestamp] => 1638474867 ) [8] => Array ( [title] => MLB: It?s official, Major League Baseball?s work stoppage begins, the first in 27 years [link] => https://redhatbeauty.com/popular-sports/mlb-its-official-major-league-baseballs-work-stoppage-begins-the-first-in-27-years/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 19:11:37 +0000 [category] => Popular SportsBaseballsLeagueMajorMlbOfficialstoppage [guid] => https://redhatbeauty.com/?p=7961 [description] => Major League Baseball has officially instituted a lockout (Strike). The 2016-2021 collective bargaining agreement between MLB owners and the players’ union expired at 10:59 p.m. Central Time tonight. Commissioner Rob Manfred announced the lockout as part of a previously prepared letter to fans (the full text is available here), Manfred wrote in part: Simply put, ... Read more [content] => Array ( [encoded] =>

Major League Baseball has officially instituted a lockout (Strike). The 2016-2021 collective bargaining agreement between MLB owners and the players’ union expired at 10:59 p.m. Central Time tonight.

Commissioner Rob Manfred announced the lockout as part of a previously prepared letter to fans (the full text is available here), Manfred wrote in part:

Simply put, we believe that an offseason lockout is the best mechanism to protect the 2022 season. We hope that the lockout will jump-start negotiations and lead us to an agreement that allows the season to start on time. This defensive blocking was necessary because the vision of the Major League Baseball Players Association (MLBPA) threatened the ability of most teams to be competitive. It is simply not a viable option. From the beginning, the MLBPA has not been willing to move from its initial position, compromise or collaborate on solutions. “

Manfred went on to assert that the MLBPA “came to the bargaining table with a confrontational strategy on compromise” and “never wavered collectively from the most extreme set of proposals in its history, including significant cuts to the revenue sharing system, a weakening of the competitive balance tax, and shortening the length of time players play for their teams. All of these changes would make our game less competitive, not more. “

The MLB Players Association issued a statement of its own (on Twitter). Read in part:

Major League Baseball has announced a player lockout, shutting down our industry. This closure is a dramatic move, regardless of the timing. It is not required by law or for any other reason. It was the owners’ decision, plain and simple, to calculate specifically to pressure Players to relinquish rights and benefits, and abandon good faith negotiation proposals that will benefit not only Players, but the game and the industry as a whole. . ? We remain determined to return to the field under the terms of a collective bargaining agreement that is fair to all parties and provides fans with the best version of the game we all love. “

A transaction freeze will be the most visible appearance of the lockdown to fans, at least until the possibility of game cancellations if no deal is reached within a couple of months.

However, the ban on transactions is not the only effect. ESPN’s Jeff Passan explored some intricacies of the situation earlier this week in an article worth reading in its entirety.

Some of the less visible effects: Injured players will not be able to communicate with team coaching staff, players can no longer use team-run mental health services, and some foreign-born players may have visa issues. Also don’t expect press conferences for newly hired players or interviews with GMs:

The lockout is uncharted territory for a generation of baseball fans; This is the first work stoppage in the history of this website. It will be the first official work stoppage since 1994, breaking a streak of almost three decades of labor peace. The parties had discussions every day this week, but it does not appear that they have made much progress.

The league declined to make a counter offer on the time-of-service structure and luxury tax thresholds unless the MLBPA abandoned its efforts to boost players’ eligibility for free agency, a lawsuit the union allegedly rejected.

The league gave up some ground on the competitive equilibrium tax, and MLB proposed gradually increasing the lower tax threshold to an endpoint of $ 220 million:

However, that remains slightly below the MLBPA’s $ 240MM target, and it’s unclear whether the league’s proposed increase also involved a corresponding increase in penalties paid for exceeding those markers.

Certainly, there is a lot to work on beyond the luxury tax. The league’s time of service system, umpiring, and fundamental competitive structure (including the number of playoff teams) will be discussed at least for the next several weeks.

That says nothing about potential field rule changes like the extra inning runner and universal designated hitter. With so much to be determined, it is generally not expected that a deal will be reached in a short time:

The 2022 spring training schedule could potentially dictate when the lockout ends, with owners likely reluctant to give up the revenue from exhibition games.

It may interest you: MLB Major League Baseball Unemployment Almost Certain Dec. 2

The Winter Meetings, originally scheduled for December 6-9 in Orlando, have been canceled, reports ESPN’s Jeff Passan (Twitter link). The commissioner is scheduled to hold a press conference tomorrow, Thursday morning.

Rafael Martinez

I am a fan of the King of Sports, especially the Boston Red Sox in MLB and in general all of Mexican baseball. This profession has given me the opportunity to cover major events such as the Caribbean Series, the LMB All Star, LMP (uninterrupted since 2009), signings of important players. I had the chance to attend the 2013 World Classic in Arizona, USA, albeit as a fan. Apart from this beautiful sport, I love basketball, where I have also narrated games and even an NBA friendly 10 years ago, but I carry baseball in my veins. Graduated in Communication Sciences from the Autonomous University of Sinaloa (UAS) , from which I graduated in 2011. I was born in Mazatlán, Sinaloa and started in the world of sports journalism in 2004 in the newspaper El Sol de Mazatlán, where I was a baseball columnist and reporter at the same time. In January 2009 I came to El Debate as a journalist reporter and it was almost six years (in the first stage), until in November 2014 I emigrated to the radio providing my services in Línea Directa-Grupo RSN. My cycle there ended in July 2019 and within days, El Debate gave me another opportunity to work and opened the doors for me again. That is how I came to Al Bat, where I have been since 2019 as a web journalist.

see more

We would like to give thanks to the writer of this write-up for this outstanding content

MLB: It’s official, Major League Baseball’s work stoppage begins, the first in 27 years

) [summary] => Major League Baseball has officially instituted a lockout (Strike). The 2016-2021 collective bargaining agreement between MLB owners and the players’ union expired at 10:59 p.m. Central Time tonight. Commissioner Rob Manfred announced the lockout as part of a previously prepared letter to fans (the full text is available here), Manfred wrote in part: Simply put, ... Read more [atom_content] =>

Major League Baseball has officially instituted a lockout (Strike). The 2016-2021 collective bargaining agreement between MLB owners and the players’ union expired at 10:59 p.m. Central Time tonight.

Commissioner Rob Manfred announced the lockout as part of a previously prepared letter to fans (the full text is available here), Manfred wrote in part:

Simply put, we believe that an offseason lockout is the best mechanism to protect the 2022 season. We hope that the lockout will jump-start negotiations and lead us to an agreement that allows the season to start on time. This defensive blocking was necessary because the vision of the Major League Baseball Players Association (MLBPA) threatened the ability of most teams to be competitive. It is simply not a viable option. From the beginning, the MLBPA has not been willing to move from its initial position, compromise or collaborate on solutions. “

Manfred went on to assert that the MLBPA “came to the bargaining table with a confrontational strategy on compromise” and “never wavered collectively from the most extreme set of proposals in its history, including significant cuts to the revenue sharing system, a weakening of the competitive balance tax, and shortening the length of time players play for their teams. All of these changes would make our game less competitive, not more. “

The MLB Players Association issued a statement of its own (on Twitter). Read in part:

Major League Baseball has announced a player lockout, shutting down our industry. This closure is a dramatic move, regardless of the timing. It is not required by law or for any other reason. It was the owners’ decision, plain and simple, to calculate specifically to pressure Players to relinquish rights and benefits, and abandon good faith negotiation proposals that will benefit not only Players, but the game and the industry as a whole. . ? We remain determined to return to the field under the terms of a collective bargaining agreement that is fair to all parties and provides fans with the best version of the game we all love. “

A transaction freeze will be the most visible appearance of the lockdown to fans, at least until the possibility of game cancellations if no deal is reached within a couple of months.

However, the ban on transactions is not the only effect. ESPN’s Jeff Passan explored some intricacies of the situation earlier this week in an article worth reading in its entirety.

Some of the less visible effects: Injured players will not be able to communicate with team coaching staff, players can no longer use team-run mental health services, and some foreign-born players may have visa issues. Also don’t expect press conferences for newly hired players or interviews with GMs:

The lockout is uncharted territory for a generation of baseball fans; This is the first work stoppage in the history of this website. It will be the first official work stoppage since 1994, breaking a streak of almost three decades of labor peace. The parties had discussions every day this week, but it does not appear that they have made much progress.

The league declined to make a counter offer on the time-of-service structure and luxury tax thresholds unless the MLBPA abandoned its efforts to boost players’ eligibility for free agency, a lawsuit the union allegedly rejected.

The league gave up some ground on the competitive equilibrium tax, and MLB proposed gradually increasing the lower tax threshold to an endpoint of $ 220 million:

However, that remains slightly below the MLBPA’s $ 240MM target, and it’s unclear whether the league’s proposed increase also involved a corresponding increase in penalties paid for exceeding those markers.

Certainly, there is a lot to work on beyond the luxury tax. The league’s time of service system, umpiring, and fundamental competitive structure (including the number of playoff teams) will be discussed at least for the next several weeks.

That says nothing about potential field rule changes like the extra inning runner and universal designated hitter. With so much to be determined, it is generally not expected that a deal will be reached in a short time:

The 2022 spring training schedule could potentially dictate when the lockout ends, with owners likely reluctant to give up the revenue from exhibition games.

It may interest you: MLB Major League Baseball Unemployment Almost Certain Dec. 2

The Winter Meetings, originally scheduled for December 6-9 in Orlando, have been canceled, reports ESPN’s Jeff Passan (Twitter link). The commissioner is scheduled to hold a press conference tomorrow, Thursday morning.

Rafael Martinez

I am a fan of the King of Sports, especially the Boston Red Sox in MLB and in general all of Mexican baseball. This profession has given me the opportunity to cover major events such as the Caribbean Series, the LMB All Star, LMP (uninterrupted since 2009), signings of important players. I had the chance to attend the 2013 World Classic in Arizona, USA, albeit as a fan. Apart from this beautiful sport, I love basketball, where I have also narrated games and even an NBA friendly 10 years ago, but I carry baseball in my veins. Graduated in Communication Sciences from the Autonomous University of Sinaloa (UAS) , from which I graduated in 2011. I was born in Mazatlán, Sinaloa and started in the world of sports journalism in 2004 in the newspaper El Sol de Mazatlán, where I was a baseball columnist and reporter at the same time. In January 2009 I came to El Debate as a journalist reporter and it was almost six years (in the first stage), until in November 2014 I emigrated to the radio providing my services in Línea Directa-Grupo RSN. My cycle there ended in July 2019 and within days, El Debate gave me another opportunity to work and opened the doors for me again. That is how I came to Al Bat, where I have been since 2019 as a web journalist.

see more

We would like to give thanks to the writer of this write-up for this outstanding content

MLB: It’s official, Major League Baseball’s work stoppage begins, the first in 27 years

[date_timestamp] => 1638472297 ) [9] => Array ( [title] => New computational approach predicts chemical reactions at high temperatures [link] => https://redhatbeauty.com/healthandscience/new-computational-approach-predicts-chemical-reactions-at-high-temperatures/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 18:37:26 +0000 [category] => Health And ScienceapproachchemicalComputationalpredictsreactionstemperatures [guid] => https://redhatbeauty.com/?p=7956 [description] => Journal Reference: Jose Antonio Garrido Torres, Vahe Gharakhanyan, Nongnuch Artrith, Tobias Hoffmann Eegholm, Alexander Urban. Augmenting zero-Kelvin quantum mechanics with machine learning for the prediction of chemical reactions at high temperatures. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27154-2 A Columbia Engineering team reports that they have developed a new computation technique that, through combining quantum ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Jose Antonio Garrido Torres, Vahe Gharakhanyan, Nongnuch Artrith, Tobias Hoffmann Eegholm, Alexander Urban. Augmenting zero-Kelvin quantum mechanics with machine learning for the prediction of chemical reactions at high temperatures. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27154-2

A Columbia Engineering team reports that they have developed a new computation technique that, through combining quantum mechanics and machine learning, can accurately predict the reduction temperature of metal oxides to their base metals. Their approach is computationally as efficient as conventional calculations at zero temperature and, in their tests, more accurate than computationally demanding simulations of temperature effects using quantum chemistry methods. The study, led by Alexander Urban, assistant professor of chemical engineering, is published today by Nature Communications ASAP.

?Decarbonizing the chemical industry is critical if we are to transition to a more sustainable future, but developing alternatives for established industrial processes is very cost-intensive and time-consuming,? Urban said. ?A bottom-up computational process design that doesn?t require initial experimental input would be an attractive alternative but has so far not been realized. This new study is, to our knowledge, the first time that a hybrid approach, combining computational calculations with AI, has been attempted for this application. And it?s the first demonstration that quantum-mechanics-based calculations can be used for the design of high-temperature processes.?

The researchers knew that, at very low temperatures, quantum-mechanics-based calculations can accurately predict the energy that chemical reactions require or release. They augmented this zero-temperature theory with a machine-learning model that learned the temperature dependence from publicly available high-temperature measurements. They designed their approach, which focused on extracting metal at high temperatures, to also predict the change of the ?free energy? with the temperature, whether it was high or low.

?Free energy is a key quantity of thermodynamics and other temperature-dependent quantities can, in principle, be derived from it,? said José A. Garrido Torres, the paper?s first author who was a postdoctoral fellow in Urban?s lab and is now a research scientist at Princeton. ?So we expect that our approach will also be useful to predict, for example, melting temperatures and solubilities for the design of clean electrolytic metal extraction processes that are powered by renewable electric energy.?

?The future just got a little bit closer,? said Nick Birbilis, Deputy Dean of the Australian National University College of Engineering and Computer Science and an expert for materials design with a focus on corrosion durability, who was not involved in the study. ?Much of the human effort and sunken capital over the past century has been in the development of materials that we use every day ? and that we rely on for our power, flight, and entertainment. Materials development is slow and costly, which makes machine learning a critical development for future materials design. In order for machine learning and AI to meet its potential, models must be mechanistically relevant and interpretable. This is precisely what the work of Urban and Garrido Torres demonstrates. Furthermore, the work takes a whole-of-system approach for one of the first times, linking atomistic simulations on one end engineering applications on the other ? via advanced algorithms.?

The team is now working on extending the approach to other temperature-dependent materials properties, such as solubility, conductivity, and melting, that are needed to design electrolytic metal extraction processes that are carbon-free and powered by clean electric energy.

We wish to say thanks to the author of this article for this incredible material

New computational approach predicts chemical reactions at high temperatures

) [summary] => Journal Reference: Jose Antonio Garrido Torres, Vahe Gharakhanyan, Nongnuch Artrith, Tobias Hoffmann Eegholm, Alexander Urban. Augmenting zero-Kelvin quantum mechanics with machine learning for the prediction of chemical reactions at high temperatures. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27154-2 A Columbia Engineering team reports that they have developed a new computation technique that, through combining quantum ... Read more [atom_content] =>

Journal Reference:

  1. Jose Antonio Garrido Torres, Vahe Gharakhanyan, Nongnuch Artrith, Tobias Hoffmann Eegholm, Alexander Urban. Augmenting zero-Kelvin quantum mechanics with machine learning for the prediction of chemical reactions at high temperatures. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27154-2

A Columbia Engineering team reports that they have developed a new computation technique that, through combining quantum mechanics and machine learning, can accurately predict the reduction temperature of metal oxides to their base metals. Their approach is computationally as efficient as conventional calculations at zero temperature and, in their tests, more accurate than computationally demanding simulations of temperature effects using quantum chemistry methods. The study, led by Alexander Urban, assistant professor of chemical engineering, is published today by Nature Communications ASAP.

?Decarbonizing the chemical industry is critical if we are to transition to a more sustainable future, but developing alternatives for established industrial processes is very cost-intensive and time-consuming,? Urban said. ?A bottom-up computational process design that doesn?t require initial experimental input would be an attractive alternative but has so far not been realized. This new study is, to our knowledge, the first time that a hybrid approach, combining computational calculations with AI, has been attempted for this application. And it?s the first demonstration that quantum-mechanics-based calculations can be used for the design of high-temperature processes.?

The researchers knew that, at very low temperatures, quantum-mechanics-based calculations can accurately predict the energy that chemical reactions require or release. They augmented this zero-temperature theory with a machine-learning model that learned the temperature dependence from publicly available high-temperature measurements. They designed their approach, which focused on extracting metal at high temperatures, to also predict the change of the ?free energy? with the temperature, whether it was high or low.

?Free energy is a key quantity of thermodynamics and other temperature-dependent quantities can, in principle, be derived from it,? said José A. Garrido Torres, the paper?s first author who was a postdoctoral fellow in Urban?s lab and is now a research scientist at Princeton. ?So we expect that our approach will also be useful to predict, for example, melting temperatures and solubilities for the design of clean electrolytic metal extraction processes that are powered by renewable electric energy.?

?The future just got a little bit closer,? said Nick Birbilis, Deputy Dean of the Australian National University College of Engineering and Computer Science and an expert for materials design with a focus on corrosion durability, who was not involved in the study. ?Much of the human effort and sunken capital over the past century has been in the development of materials that we use every day ? and that we rely on for our power, flight, and entertainment. Materials development is slow and costly, which makes machine learning a critical development for future materials design. In order for machine learning and AI to meet its potential, models must be mechanistically relevant and interpretable. This is precisely what the work of Urban and Garrido Torres demonstrates. Furthermore, the work takes a whole-of-system approach for one of the first times, linking atomistic simulations on one end engineering applications on the other ? via advanced algorithms.?

The team is now working on extending the approach to other temperature-dependent materials properties, such as solubility, conductivity, and melting, that are needed to design electrolytic metal extraction processes that are carbon-free and powered by clean electric energy.

We wish to say thanks to the author of this article for this incredible material

New computational approach predicts chemical reactions at high temperatures

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