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Moustache Brothers
Rinaldi, Locatelli, Bassani: the Italian trio that can amaze in 2022
Ancient lineage of algae found to include five ?cryptic? species
Grand Prix Final, Dell?Aquila enterprise: it?s gold! Korean Jang beaten
Volcanic fertilization of the oceans drove severe mass extinction
Machine learning helps mathematicians make new connections
Toro show for half an hour, then red in Singo and Empoli comeback
Blue, first step towards the World Cup: overwhelmed the Scots
One of the most important Final Fantasy, and its role in Endwalker
Targeting the brain?s immune cells may help prevent or treat Alzheimer?s disease
Bottas? nightmare: ?In 2014 obsessed with weight: I was close to leaving F1?

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                    [title] => Rinaldi, Locatelli, Bassani: the Italian trio that can amaze in 2022
                    [link] => https://moustachebrothers.com/rinaldi-locatelli-bassani-the-italian-trio-that-can-amaze-in-2022/
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                            [creator] => Eden Kently
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                    [pubdate] => Fri, 03 Dec 2021 00:26:00 +0000
                    [category] => MotorcyclingamazeBassaniItalianLocatelliRinalditrio
                    [guid] => https://moustachebrothers.com/?p=8696
                    [description] => Will next year’s World SBK be just a three-way fight between Razgatlioglu, Rea and Bautista? Watch out for the Italian trio, which has the technical means and speed to enter the title race The World Sbk 2021 has just ended with the triumph of Toprak Razgatlioglu (Yamaha) who after a fierce fight until the last ... Read more
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Will next year’s World SBK be just a three-way fight between Razgatlioglu, Rea and Bautista? Watch out for the Italian trio, which has the technical means and speed to enter the title race

The World Sbk 2021 has just ended with the triumph of Toprak Razgatlioglu (Yamaha) who after a fierce fight until the last round on the Indonesian track of Mandalika has dethroned the ruler of the last six years Jonathan Rea (Kawasaki), and we already think to next season.

sbk 2022, i team

?

The official 2022 deployments are almost defined. Yamaha confirms the Razgatlioglu-Locatelli duo, as does the junior team Grt with Kohta Nozane and Garrett Gerloff and the Gil Motor Sport team with Cristophe Ponsson. Ditto Kawasaki with the officers Rea and Lowes, with Luca Mahias in Team Puccetti and probably Isaac Vińales again with Orelac Verdnatura and with Loris Cresson and another to be defined in Team Pedercini. News from Ducati, with Alvaro Bautista returning after two years on the Panigale V4, together with the reconfirmed Michael Ruben Rinaldi. News also in the three ?private? teams: Go Eleven replaced the outgoing Chaz Davies with Philipp Oettl; Totocorsa Racing confirmed Bassani; Barni Racing focuses on the twenty year old Luca Bernardi from San Marino. BMW renews with the arrival of Michael Van der Mark’s teammate Redding, plus Loris Baz together with Eugene Laverty as test driver. Almost certain a fifth M 1000 RR of Team B-Max with 21-year-old Gabriele Ruiu from Rome. Honda is betting on the almost 22-year-old Iker Lecuona out of MotoGP and on the 24-year-old Xavi Vierge who has been in Moto2 for seven seasons. Waiting for confirmation in the Mie Racing Team, Leandro Tati Mercado, flanked by a new entry.

sbk 2022, and topics

?

In 2022, therefore, the World SBK deployment should count on six Kawasakis, five Yamahas, five Ducatis, four Hondas, four (perhaps five) BMWs for a total of 24/26 riders, three or four more than in 2021. It is not difficult to identify which will be the main themes of interest of the 2022 championship: with Razgatlioglu aiming for an encore also as a push towards MotoGP since 2023; with Rea who wants to recover “his” number 1 by trying to attack the title number 7 (then also the eighth?) before the farewell to racing; with Alvaro Bautista, on his return with the Ducati V4 to make us forget the fluctuating (and ultimately disappointing) 2019 season on the red and cancel 2020 and 2021 with Hondas. Of the three “bigs”, the one who could encounter more difficulties is Bautista, a great handle but swinging and with less “impact force” than two lions such as Razgatlioglu and Rea, especially in hand-to-hand combat, which is now the leitmotiv of the SBK . Bautista, however, since his first two-day test in Jerez on the red V4, has already performed well in his 84 laps, certainly not desperate, but at the end finishing half a second behind Pirro’s Ducati MotoGP, demonstrating an immediately recovered feeling , which bodes well. Put this way, it is not difficult to hypothesize that it will be very difficult for the other drivers to get involved in the fight of the “trio of aces” Razgatlioglu-Rea-Bautista. After evaluating the forces on the field, the podium is therefore ?booked? by the axes of Yamaha, Kawasaki, Ducati. But, as we know, the predictions are made to be proven wrong.

the outsiders of the sbk

?

If someone managed to wedge himself into the ?noble? trio he could go from outsider to winner and even, from 2023, aim to become the new ?king of the forest?. We will see. In particular, there is expectation for the Italian riders who reached fourth place this year with Andrea Locatelli (Yamaha), in fifth place with Michael Ruben Rinaldi (Ducati), in ninth place with Alex Bassani (Ducati). The question is: will they be able to do even better than they did in 2021, fully entering the fight for the SBK 2022 world title? These are three young people who certainly cannot boast the roster of the most mature and accredited protagonists of Sbk 2021: Razgatlioglu, Rea, Redding. The three Italians have very different technical-competitive characteristics, different experiences and different results. All three are good, indeed excellent drivers, but placing them today on the level of the big three (especially the Turkish and Northern Irishmen) seems a stretch, if not a gamble.

the chances of the three Italians

?

Of these three steel peaks (talking about spearheads is exaggerated) it is Rinaldi (25 years old) who has the best potential: an experienced, run-in, fast runner, he knows how to win even though he has little continuity. The cup as winner of the Sbk 2020 Independent Trophy is a good omen for the Rimini player and even more so are the three victories, the two second places and the two thirds obtained this year. Locatelli (25 years as Rinaldi and like his new world champion Turkish teammate) has a good pace, he is a good hammer, he scores (4th place in the final with four podiums): however (still) missing in Sbk of the winning twist, of the “hook” that knocks out the opponent. Bassani is the youngest (22 years old) but also the one with a poorer curriculum that however came to the attention with a nice crescendo at the end of 2021: a 2nd place, two quarters, two fifths demonstrating a strong character, of a handle driven by a fine talent and a great desire to do well, to do better and better, a young man who does not seem to suffer from any inferiority complex. For now, all that remains is to enjoy a qualitatively and quantitatively strong presence of Italian drivers in all the world speed championships. In particular, in Sbk it is not forbidden to dream, finally renewing the triumphs of Max Biaggi and Aprilia in 2010 and 2012.

We wish to say thanks to the author of this post for this remarkable web content

Rinaldi, Locatelli, Bassani: the Italian trio that can amaze in 2022

) [summary] => Will next year’s World SBK be just a three-way fight between Razgatlioglu, Rea and Bautista? Watch out for the Italian trio, which has the technical means and speed to enter the title race The World Sbk 2021 has just ended with the triumph of Toprak Razgatlioglu (Yamaha) who after a fierce fight until the last ... Read more [atom_content] =>

Will next year’s World SBK be just a three-way fight between Razgatlioglu, Rea and Bautista? Watch out for the Italian trio, which has the technical means and speed to enter the title race

The World Sbk 2021 has just ended with the triumph of Toprak Razgatlioglu (Yamaha) who after a fierce fight until the last round on the Indonesian track of Mandalika has dethroned the ruler of the last six years Jonathan Rea (Kawasaki), and we already think to next season.

sbk 2022, i team

?

The official 2022 deployments are almost defined. Yamaha confirms the Razgatlioglu-Locatelli duo, as does the junior team Grt with Kohta Nozane and Garrett Gerloff and the Gil Motor Sport team with Cristophe Ponsson. Ditto Kawasaki with the officers Rea and Lowes, with Luca Mahias in Team Puccetti and probably Isaac Vińales again with Orelac Verdnatura and with Loris Cresson and another to be defined in Team Pedercini. News from Ducati, with Alvaro Bautista returning after two years on the Panigale V4, together with the reconfirmed Michael Ruben Rinaldi. News also in the three ?private? teams: Go Eleven replaced the outgoing Chaz Davies with Philipp Oettl; Totocorsa Racing confirmed Bassani; Barni Racing focuses on the twenty year old Luca Bernardi from San Marino. BMW renews with the arrival of Michael Van der Mark’s teammate Redding, plus Loris Baz together with Eugene Laverty as test driver. Almost certain a fifth M 1000 RR of Team B-Max with 21-year-old Gabriele Ruiu from Rome. Honda is betting on the almost 22-year-old Iker Lecuona out of MotoGP and on the 24-year-old Xavi Vierge who has been in Moto2 for seven seasons. Waiting for confirmation in the Mie Racing Team, Leandro Tati Mercado, flanked by a new entry.

sbk 2022, and topics

?

In 2022, therefore, the World SBK deployment should count on six Kawasakis, five Yamahas, five Ducatis, four Hondas, four (perhaps five) BMWs for a total of 24/26 riders, three or four more than in 2021. It is not difficult to identify which will be the main themes of interest of the 2022 championship: with Razgatlioglu aiming for an encore also as a push towards MotoGP since 2023; with Rea who wants to recover “his” number 1 by trying to attack the title number 7 (then also the eighth?) before the farewell to racing; with Alvaro Bautista, on his return with the Ducati V4 to make us forget the fluctuating (and ultimately disappointing) 2019 season on the red and cancel 2020 and 2021 with Hondas. Of the three “bigs”, the one who could encounter more difficulties is Bautista, a great handle but swinging and with less “impact force” than two lions such as Razgatlioglu and Rea, especially in hand-to-hand combat, which is now the leitmotiv of the SBK . Bautista, however, since his first two-day test in Jerez on the red V4, has already performed well in his 84 laps, certainly not desperate, but at the end finishing half a second behind Pirro’s Ducati MotoGP, demonstrating an immediately recovered feeling , which bodes well. Put this way, it is not difficult to hypothesize that it will be very difficult for the other drivers to get involved in the fight of the “trio of aces” Razgatlioglu-Rea-Bautista. After evaluating the forces on the field, the podium is therefore ?booked? by the axes of Yamaha, Kawasaki, Ducati. But, as we know, the predictions are made to be proven wrong.

the outsiders of the sbk

?

If someone managed to wedge himself into the ?noble? trio he could go from outsider to winner and even, from 2023, aim to become the new ?king of the forest?. We will see. In particular, there is expectation for the Italian riders who reached fourth place this year with Andrea Locatelli (Yamaha), in fifth place with Michael Ruben Rinaldi (Ducati), in ninth place with Alex Bassani (Ducati). The question is: will they be able to do even better than they did in 2021, fully entering the fight for the SBK 2022 world title? These are three young people who certainly cannot boast the roster of the most mature and accredited protagonists of Sbk 2021: Razgatlioglu, Rea, Redding. The three Italians have very different technical-competitive characteristics, different experiences and different results. All three are good, indeed excellent drivers, but placing them today on the level of the big three (especially the Turkish and Northern Irishmen) seems a stretch, if not a gamble.

the chances of the three Italians

?

Of these three steel peaks (talking about spearheads is exaggerated) it is Rinaldi (25 years old) who has the best potential: an experienced, run-in, fast runner, he knows how to win even though he has little continuity. The cup as winner of the Sbk 2020 Independent Trophy is a good omen for the Rimini player and even more so are the three victories, the two second places and the two thirds obtained this year. Locatelli (25 years as Rinaldi and like his new world champion Turkish teammate) has a good pace, he is a good hammer, he scores (4th place in the final with four podiums): however (still) missing in Sbk of the winning twist, of the “hook” that knocks out the opponent. Bassani is the youngest (22 years old) but also the one with a poorer curriculum that however came to the attention with a nice crescendo at the end of 2021: a 2nd place, two quarters, two fifths demonstrating a strong character, of a handle driven by a fine talent and a great desire to do well, to do better and better, a young man who does not seem to suffer from any inferiority complex. For now, all that remains is to enjoy a qualitatively and quantitatively strong presence of Italian drivers in all the world speed championships. In particular, in Sbk it is not forbidden to dream, finally renewing the triumphs of Max Biaggi and Aprilia in 2010 and 2012.

We wish to say thanks to the author of this post for this remarkable web content

Rinaldi, Locatelli, Bassani: the Italian trio that can amaze in 2022

[date_timestamp] => 1638491160 ) [1] => Array ( [title] => Ancient lineage of algae found to include five ?cryptic? species [link] => https://moustachebrothers.com/ancient-lineage-of-algae-found-to-include-five-cryptic-species/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 23:53:35 +0000 [category] => Health And Sciencealgaeancientcrypticincludelineagespecies [guid] => https://moustachebrothers.com/?p=8691 [description] => Journal Reference: Iker Irisarri, Tatyana Darienko, Thomas Pröschold, Janine M. R. Fürst-Jansen, Mahwash Jamy, Jan de Vries. Unexpected cryptic species among streptophyte algae most distant to land plants. Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1963) DOI: 10.1098/rspb.2021.2168 While small in number and vanishingly rare, these humble algae are valuable in terms ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Iker Irisarri, Tatyana Darienko, Thomas Pröschold, Janine M. R. Fürst-Jansen, Mahwash Jamy, Jan de Vries. Unexpected cryptic species among streptophyte algae most distant to land plants. Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1963) DOI: 10.1098/rspb.2021.2168

While small in number and vanishingly rare, these humble algae are valuable in terms of the evolutionary pathways they reveal. They diverged from land plants over a billion years ago, making them descendants of the ancient algal ancestor that also gave rise to modern land plants (and various other algae). The study started by tracking down and screening all known algae that can be assigned to Chlorokybus, including cultures from public algal collections and fresh samples obtained in Ukraine, Chile, and Costa Rica. ?We even tried to collect Chlorokybus in the place where it was first described in the 1940s, living on a stone monument in the Schönbrunn Palace in Vienna. But we could not find it, probably because the monument had been recently restored,? says Dr Tatyana Darienko.

The researchers then conducted genetic analyses on the collected samples. The first analysis, based on just a few genes, showed marked genetic divergences among the various isolated algae. Hundreds of gene sequences obtained through large-scale genomic sequencing confirmed these unexpected results. This led the authors to recognize that there were actually five distinct species hiding under a single common name. These are called ?cryptic species? to reflect the difficulty or impossibility of telling them apart by simple observation. In fact, traditional microscopy revealed no obvious differences between the five species. However, the genetic data told a different story: there were clear differences in gene expression, proving there were genetic differences among the species that are not observable to the naked eye.

Lead author Dr Iker Irisarri, University of Göttingen, explained, ?The fact that these algae look so similar is a real surprise, given that some of these species might have diverged from each other over 70 million years ago! But the genetic data are unambiguous.? This study sheds new light into the biodiversity of a little studied algal group that occupies a key evolutionary position, being a close relative of land plants. This has important implications for our understanding of plant form and function. ?Accounting for the real species diversity of this group of algae is paramount for ongoing comparative genomic studies that help explain the origin, adaptation and development of land plants and their algal relatives? says Professor Jan de Vries, University of Göttingen.

We want to say thanks to the author of this post for this awesome material

Ancient lineage of algae found to include five ?cryptic? species

) [summary] => Journal Reference: Iker Irisarri, Tatyana Darienko, Thomas Pröschold, Janine M. R. Fürst-Jansen, Mahwash Jamy, Jan de Vries. Unexpected cryptic species among streptophyte algae most distant to land plants. Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1963) DOI: 10.1098/rspb.2021.2168 While small in number and vanishingly rare, these humble algae are valuable in terms ... Read more [atom_content] =>

Journal Reference:

  1. Iker Irisarri, Tatyana Darienko, Thomas Pröschold, Janine M. R. Fürst-Jansen, Mahwash Jamy, Jan de Vries. Unexpected cryptic species among streptophyte algae most distant to land plants. Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1963) DOI: 10.1098/rspb.2021.2168

While small in number and vanishingly rare, these humble algae are valuable in terms of the evolutionary pathways they reveal. They diverged from land plants over a billion years ago, making them descendants of the ancient algal ancestor that also gave rise to modern land plants (and various other algae). The study started by tracking down and screening all known algae that can be assigned to Chlorokybus, including cultures from public algal collections and fresh samples obtained in Ukraine, Chile, and Costa Rica. ?We even tried to collect Chlorokybus in the place where it was first described in the 1940s, living on a stone monument in the Schönbrunn Palace in Vienna. But we could not find it, probably because the monument had been recently restored,? says Dr Tatyana Darienko.

The researchers then conducted genetic analyses on the collected samples. The first analysis, based on just a few genes, showed marked genetic divergences among the various isolated algae. Hundreds of gene sequences obtained through large-scale genomic sequencing confirmed these unexpected results. This led the authors to recognize that there were actually five distinct species hiding under a single common name. These are called ?cryptic species? to reflect the difficulty or impossibility of telling them apart by simple observation. In fact, traditional microscopy revealed no obvious differences between the five species. However, the genetic data told a different story: there were clear differences in gene expression, proving there were genetic differences among the species that are not observable to the naked eye.

Lead author Dr Iker Irisarri, University of Göttingen, explained, ?The fact that these algae look so similar is a real surprise, given that some of these species might have diverged from each other over 70 million years ago! But the genetic data are unambiguous.? This study sheds new light into the biodiversity of a little studied algal group that occupies a key evolutionary position, being a close relative of land plants. This has important implications for our understanding of plant form and function. ?Accounting for the real species diversity of this group of algae is paramount for ongoing comparative genomic studies that help explain the origin, adaptation and development of land plants and their algal relatives? says Professor Jan de Vries, University of Göttingen.

We want to say thanks to the author of this post for this awesome material

Ancient lineage of algae found to include five ?cryptic? species

[date_timestamp] => 1638489215 ) [2] => Array ( [title] => Grand Prix Final, Dell?Aquila enterprise: it?s gold! Korean Jang beaten [link] => https://moustachebrothers.com/grand-prix-final-dellaquila-enterprise-its-gold-korean-jang-beaten/ [dc] => Array ( [creator] => Tim Hall ) [pubdate] => Thu, 02 Dec 2021 23:04:55 +0000 [category] => TaekwondobeatenDellAquilaenterprisefinalgoldgrandJangKoreanPrix [guid] => https://moustachebrothers.com/?p=8685 [description] => In Moscow Vito beats the number one in the world for 21-18: “As a child I watched the race in streaming, now I not only participate in it, but I win. Tokyo 2020? I will prove that it is no coincidence” “It is not enough for me to be qualified for Tokyo 2020, I want ... Read more [content] => Array ( [encoded] =>

In Moscow Vito beats the number one in the world for 21-18: “As a child I watched the race in streaming, now I not only participate in it, but I win. Tokyo 2020? I will prove that it is no coincidence”

“It is not enough for me to be qualified for Tokyo 2020, I want to win gold”. No sooner said than done. Vito Dell’Aquila climbs on the first step of the podium in the -58 kg at the Grand Prix Final in Moscow, beating the Korean Jun Jang 21-18. The 19-year-old from Mesagne, former European Champion, wins and convinces in what is among the most important competitions of the year which can only be accessed by the best 16 in the world. And the final sees him impose himself on the number 1 of the ranking that seemed unbeatable, until today: “I still can’t realize that I have this gold medal around my neck”. A success that crowns the official validity of the Olympic pass obtained yesterday, the points obtained already in overcoming the preliminaries have in fact delivered the direct qualification through ranking to the blue: “I am very happy, I want to be competitive also in Tokyo 2020 and to be found ready I will have to continue to train hard. I will show that this victory is not the result of chance “.

THE FINAL

?

The final with the Korean Jun Jang is fiery, then defined by the commentators among the most exciting of the day. The athlete from the Carabinieri Sports Center starts immediately convinced, closing the lead in both the first round (8-5) and the second (10-8), but it is the last round to give a show with a back and forth between two top athletes level: on 17-16, the rise of the blue begins at 7 seconds from the end and definitively ends the match at 21-18. “In the final I was good because I was in the lead, but he threw himself in and I managed to anticipate him well. With the technical director Claudio Nolano, I prepared this final from every point: it is the third time that I have clashed with Jang” . And the first to win.

DREAM AND REALITY

?

Vito has been waiting for this gold for a long time. After the two bronzes obtained at the Grand Prix of Chiba and Sofia, he finally put the brightest medal around his neck, overcoming the strongest in the category, number one in the ranking and twice World Champion. “When I was little I used to stream the race dreaming of one day being among those champions. Now not only do I step on these mats, but I also win. I don’t feel the strongest and I’m not, the Korean is still the best and he’s not a race to change everything, but I certainly want to show that this victory is not the result of chance. Other results will come and in Tokyo I will be ready “. And after a great joy, the moment of thanks arrives: “This gold is everything for my family, I have never dedicated a medal to them, but my parents are always there for me and this is the right opportunity. to thank the President Angelo Cito, the technical director Claudio Nolano, the Maestro Roberto Baglivo, the physiotherapist Francesco Zambrella, the blue staff and obviously the Carabinieri Sports Center “.

We would like to give thanks to the writer of this post for this outstanding content

Grand Prix Final, Dell’Aquila enterprise: it’s gold! Korean Jang beaten

) [summary] => In Moscow Vito beats the number one in the world for 21-18: “As a child I watched the race in streaming, now I not only participate in it, but I win. Tokyo 2020? I will prove that it is no coincidence” “It is not enough for me to be qualified for Tokyo 2020, I want ... Read more [atom_content] =>

In Moscow Vito beats the number one in the world for 21-18: “As a child I watched the race in streaming, now I not only participate in it, but I win. Tokyo 2020? I will prove that it is no coincidence”

“It is not enough for me to be qualified for Tokyo 2020, I want to win gold”. No sooner said than done. Vito Dell’Aquila climbs on the first step of the podium in the -58 kg at the Grand Prix Final in Moscow, beating the Korean Jun Jang 21-18. The 19-year-old from Mesagne, former European Champion, wins and convinces in what is among the most important competitions of the year which can only be accessed by the best 16 in the world. And the final sees him impose himself on the number 1 of the ranking that seemed unbeatable, until today: “I still can’t realize that I have this gold medal around my neck”. A success that crowns the official validity of the Olympic pass obtained yesterday, the points obtained already in overcoming the preliminaries have in fact delivered the direct qualification through ranking to the blue: “I am very happy, I want to be competitive also in Tokyo 2020 and to be found ready I will have to continue to train hard. I will show that this victory is not the result of chance “.

THE FINAL

?

The final with the Korean Jun Jang is fiery, then defined by the commentators among the most exciting of the day. The athlete from the Carabinieri Sports Center starts immediately convinced, closing the lead in both the first round (8-5) and the second (10-8), but it is the last round to give a show with a back and forth between two top athletes level: on 17-16, the rise of the blue begins at 7 seconds from the end and definitively ends the match at 21-18. “In the final I was good because I was in the lead, but he threw himself in and I managed to anticipate him well. With the technical director Claudio Nolano, I prepared this final from every point: it is the third time that I have clashed with Jang” . And the first to win.

DREAM AND REALITY

?

Vito has been waiting for this gold for a long time. After the two bronzes obtained at the Grand Prix of Chiba and Sofia, he finally put the brightest medal around his neck, overcoming the strongest in the category, number one in the ranking and twice World Champion. “When I was little I used to stream the race dreaming of one day being among those champions. Now not only do I step on these mats, but I also win. I don’t feel the strongest and I’m not, the Korean is still the best and he’s not a race to change everything, but I certainly want to show that this victory is not the result of chance. Other results will come and in Tokyo I will be ready “. And after a great joy, the moment of thanks arrives: “This gold is everything for my family, I have never dedicated a medal to them, but my parents are always there for me and this is the right opportunity. to thank the President Angelo Cito, the technical director Claudio Nolano, the Maestro Roberto Baglivo, the physiotherapist Francesco Zambrella, the blue staff and obviously the Carabinieri Sports Center “.

We would like to give thanks to the writer of this post for this outstanding content

Grand Prix Final, Dell’Aquila enterprise: it’s gold! Korean Jang beaten

[date_timestamp] => 1638486295 ) [3] => Array ( [title] => Volcanic fertilization of the oceans drove severe mass extinction [link] => https://moustachebrothers.com/volcanic-fertilization-of-the-oceans-drove-severe-mass-extinction/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 22:36:24 +0000 [category] => Health And SciencedroveextinctionfertilizationmassoceanssevereVolcanic [guid] => https://moustachebrothers.com/?p=8681 [description] => Journal Reference: Jack Longman, Benjamin J. W. Mills, Hayley R. Manners, Thomas M. Gernon & Martin R. Palmer. Late Ordovician climate change and extinctions driven by elevated volcanic nutrient supply. Nature Geoscience, 2021 DOI: 10.1038/s41561-021-00855-5 The researchers, working with colleagues at the University of Oldenburg, the University of Leeds and the University of Plymouth, studied ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Jack Longman, Benjamin J. W. Mills, Hayley R. Manners, Thomas M. Gernon & Martin R. Palmer. Late Ordovician climate change and extinctions driven by elevated volcanic nutrient supply. Nature Geoscience, 2021 DOI: 10.1038/s41561-021-00855-5

The researchers, working with colleagues at the University of Oldenburg, the University of Leeds and the University of Plymouth, studied the effects of volcanic ash and lava on ocean chemistry during a period of extreme environmental change around 450 million years ago. Their findings are published in the journal Nature Geoscience.

This period brought about intense planetary cooling, which culminated in a glaciation and the major ?Late Ordovician Mass Extinction?. This extinction led to the loss of about 85% of species dwelling in the oceans, reshaping the course of evolution of life on Earth.

?It?s been suggested that global cooling was driven by an increase in phosphorus input to the oceans? says Dr Jack Longman, lead author of the study based at the University of Oldenburg, and previously a postdoctoral researcher at Southampton. ?Phosphorus is one of the key elements of life, determining the pace at which tiny aquatic organisms like algae can use photosynthesis to convert carbon dioxide (CO2) into organic matter.? These organisms eventually settle to the seabed and are buried, ultimately reducing levels of carbon dioxide in the atmosphere, which then causes cooling.

?The unresolved puzzle is why glaciation and extinction occurred in two distinct phases at this time, separated by about 10 million years,? states Dr Tom Gernon, Associate Professor at the University of Southampton and co-author of the study. ?That requires some mechanism to pulse the supply of phosphorus, which is hard to explain.?

The team identified that two exceptionally large pulses of volcanic activity across the globe, occurring in parts of present-day North America and South China, coincided very closely with the two peaks in glaciation and extinction. ?But intense bursts of volcanism are more typically linked to massive CO2 release, which should drive global warming, so another process must be responsible for sudden cooling events,? explains Dr Gernon.

This prompted the team to consider whether a secondary process ? natural breakdown or ?weathering? of the volcanic material ? may have provided the surge in phosphorus need to explain the glaciations.

?When volcanic material is deposited in the oceans it undergoes rapid and profound chemical alteration, including release of phosphorus, effectively fertilizing the oceans,? states co-author Professor Martin Palmer from the University of Southampton. ?So, it is seemed viable hypothesis and certainly one worth testing.?

?This led our team to study volcanic ash layers in much younger marine sediments to compare their phosphorus contents before and after they were modified by interactions with seawater? said Dr Hayley Manners, a lecturer in Organic Chemistry at the University of Plymouth. Equipped with this information, the team were better placed to understand the potential geochemical impact of extensive volcanic layers from enormous eruptions during the Ordovician.

?This prompted us to develop a global biogeochemical model to understand the knock-on effects on the carbon cycle of rapidly adding a surge of phosphorus leached from volcanic deposits into the ocean,? says Dr Benjamin Mills, Associate Professor at the University of Leeds and co-author on the study.

The team discovered that widespread blankets of volcanic material laid down on the seafloor during the Ordovician Period would have released sufficient phosphorus into the ocean to drive a chain of events, including climatic cooling, glaciation, widespread reduction in ocean oxygen levels, and mass extinction.

Whilst it might be tempting to think that seeding the oceans with phosphorus may help solve the current climate crisis, the scientists caution that this may have more damaging consequences. ?Excess nutrient runoff from sources like agricultural fertilisers is a major cause of marine eutrophication ? where algae grow rapidly and then decay, consuming oxygen and causing substantial damage to ecosystems at the present day,? cautions Dr Mills.

The scientists conclude that whilst on short timescales massive volcanic eruptions can warm the climate via CO2 emissions, equally they can drive global cooling on multimillion-year timescales. ?Our study may prompt reinvestigations of other mass extinctions during Earth history,? concludes Dr Longman.

We would like to give thanks to the writer of this short article for this amazing web content

Volcanic fertilization of the oceans drove severe mass extinction

) [summary] => Journal Reference: Jack Longman, Benjamin J. W. Mills, Hayley R. Manners, Thomas M. Gernon & Martin R. Palmer. Late Ordovician climate change and extinctions driven by elevated volcanic nutrient supply. Nature Geoscience, 2021 DOI: 10.1038/s41561-021-00855-5 The researchers, working with colleagues at the University of Oldenburg, the University of Leeds and the University of Plymouth, studied ... Read more [atom_content] =>

Journal Reference:

  1. Jack Longman, Benjamin J. W. Mills, Hayley R. Manners, Thomas M. Gernon & Martin R. Palmer. Late Ordovician climate change and extinctions driven by elevated volcanic nutrient supply. Nature Geoscience, 2021 DOI: 10.1038/s41561-021-00855-5

The researchers, working with colleagues at the University of Oldenburg, the University of Leeds and the University of Plymouth, studied the effects of volcanic ash and lava on ocean chemistry during a period of extreme environmental change around 450 million years ago. Their findings are published in the journal Nature Geoscience.

This period brought about intense planetary cooling, which culminated in a glaciation and the major ?Late Ordovician Mass Extinction?. This extinction led to the loss of about 85% of species dwelling in the oceans, reshaping the course of evolution of life on Earth.

?It?s been suggested that global cooling was driven by an increase in phosphorus input to the oceans? says Dr Jack Longman, lead author of the study based at the University of Oldenburg, and previously a postdoctoral researcher at Southampton. ?Phosphorus is one of the key elements of life, determining the pace at which tiny aquatic organisms like algae can use photosynthesis to convert carbon dioxide (CO2) into organic matter.? These organisms eventually settle to the seabed and are buried, ultimately reducing levels of carbon dioxide in the atmosphere, which then causes cooling.

?The unresolved puzzle is why glaciation and extinction occurred in two distinct phases at this time, separated by about 10 million years,? states Dr Tom Gernon, Associate Professor at the University of Southampton and co-author of the study. ?That requires some mechanism to pulse the supply of phosphorus, which is hard to explain.?

The team identified that two exceptionally large pulses of volcanic activity across the globe, occurring in parts of present-day North America and South China, coincided very closely with the two peaks in glaciation and extinction. ?But intense bursts of volcanism are more typically linked to massive CO2 release, which should drive global warming, so another process must be responsible for sudden cooling events,? explains Dr Gernon.

This prompted the team to consider whether a secondary process ? natural breakdown or ?weathering? of the volcanic material ? may have provided the surge in phosphorus need to explain the glaciations.

?When volcanic material is deposited in the oceans it undergoes rapid and profound chemical alteration, including release of phosphorus, effectively fertilizing the oceans,? states co-author Professor Martin Palmer from the University of Southampton. ?So, it is seemed viable hypothesis and certainly one worth testing.?

?This led our team to study volcanic ash layers in much younger marine sediments to compare their phosphorus contents before and after they were modified by interactions with seawater? said Dr Hayley Manners, a lecturer in Organic Chemistry at the University of Plymouth. Equipped with this information, the team were better placed to understand the potential geochemical impact of extensive volcanic layers from enormous eruptions during the Ordovician.

?This prompted us to develop a global biogeochemical model to understand the knock-on effects on the carbon cycle of rapidly adding a surge of phosphorus leached from volcanic deposits into the ocean,? says Dr Benjamin Mills, Associate Professor at the University of Leeds and co-author on the study.

The team discovered that widespread blankets of volcanic material laid down on the seafloor during the Ordovician Period would have released sufficient phosphorus into the ocean to drive a chain of events, including climatic cooling, glaciation, widespread reduction in ocean oxygen levels, and mass extinction.

Whilst it might be tempting to think that seeding the oceans with phosphorus may help solve the current climate crisis, the scientists caution that this may have more damaging consequences. ?Excess nutrient runoff from sources like agricultural fertilisers is a major cause of marine eutrophication ? where algae grow rapidly and then decay, consuming oxygen and causing substantial damage to ecosystems at the present day,? cautions Dr Mills.

The scientists conclude that whilst on short timescales massive volcanic eruptions can warm the climate via CO2 emissions, equally they can drive global cooling on multimillion-year timescales. ?Our study may prompt reinvestigations of other mass extinctions during Earth history,? concludes Dr Longman.

We would like to give thanks to the writer of this short article for this amazing web content

Volcanic fertilization of the oceans drove severe mass extinction

[date_timestamp] => 1638484584 ) [4] => Array ( [title] => Machine learning helps mathematicians make new connections [link] => https://moustachebrothers.com/machine-learning-helps-mathematicians-make-new-connections/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 21:19:40 +0000 [category] => Health And ScienceconnectionshelpslearningMachinemathematicians [guid] => https://moustachebrothers.com/?p=8676 [description] => Journal Reference: Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x While computers have long been used to generate data for ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x

While computers have long been used to generate data for mathematicians, the task of identifying interesting patterns has relied mainly on the intuition of the mathematicians themselves. However, it?s now possible to generate more data than any mathematician can reasonably expect to study in a lifetime. Which is where machine learning comes in.

A paper, published today in Nature, describes how DeepMind was set the task of discerning patterns and connections in the fields of knot theory and representation theory. To the surprise of the mathematicians, new connections were suggested; the mathematicians were then able to examine these connections and prove the conjecture suggested by the AI. These results suggest that machine learning can complement mathematical research, guiding intuition about a problem.

Using the patterns identified by machine learning, mathematicians from the University of Oxford discovered a surprising connection between algebraic and geometric invariants of knots, establishing a completely new theorem in the field. The University of Sydney, meanwhile, used the connections made by the AI to bring them close to proving an old conjecture about Kazhdan-Lusztig polynomials, which has been unsolved for 40 years.

Professor Andras Juhasz, of the Mathematical Institute at the University of Oxford and co-author on the paper, said: ?Pure mathematicians work by formulating conjectures and proving these, resulting in theorems. But where do the conjectures come from?

?We have demonstrated that, when guided by mathematical intuition, machine learning provides a powerful framework that can uncover interesting and provable conjectures in areas where a large amount of data is available, or where the objects are too large to study with classical methods.?

Professor Marc Lackeby, of the Mathematical Institute at the University of Oxford and co-author, said: ?It has been fascinating to use machine learning to discover new and unexpected connections between different areas of mathematics. I believe that the work that we have done in Oxford and in Sydney in collaboration with DeepMind demonstrates that machine learning can be a genuinely useful tool in mathematical research.?

Professor Geordie Williamson, Professor of Mathematics at the University of Sydney and director of the Sydney Mathematical Research Institute and co-author, said: ?AI is an extraordinary tool. This work is one of the first times it has demonstrated its usefulness for pure mathematicians, like me.

?Intuition can take us a long way, but AI can help us find connections the human mind might not always easily spot.?

We would love to thank the writer of this short article for this remarkable content

Machine learning helps mathematicians make new connections

) [summary] => Journal Reference: Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x While computers have long been used to generate data for ... Read more [atom_content] =>

Journal Reference:

  1. Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x

While computers have long been used to generate data for mathematicians, the task of identifying interesting patterns has relied mainly on the intuition of the mathematicians themselves. However, it?s now possible to generate more data than any mathematician can reasonably expect to study in a lifetime. Which is where machine learning comes in.

A paper, published today in Nature, describes how DeepMind was set the task of discerning patterns and connections in the fields of knot theory and representation theory. To the surprise of the mathematicians, new connections were suggested; the mathematicians were then able to examine these connections and prove the conjecture suggested by the AI. These results suggest that machine learning can complement mathematical research, guiding intuition about a problem.

Using the patterns identified by machine learning, mathematicians from the University of Oxford discovered a surprising connection between algebraic and geometric invariants of knots, establishing a completely new theorem in the field. The University of Sydney, meanwhile, used the connections made by the AI to bring them close to proving an old conjecture about Kazhdan-Lusztig polynomials, which has been unsolved for 40 years.

Professor Andras Juhasz, of the Mathematical Institute at the University of Oxford and co-author on the paper, said: ?Pure mathematicians work by formulating conjectures and proving these, resulting in theorems. But where do the conjectures come from?

?We have demonstrated that, when guided by mathematical intuition, machine learning provides a powerful framework that can uncover interesting and provable conjectures in areas where a large amount of data is available, or where the objects are too large to study with classical methods.?

Professor Marc Lackeby, of the Mathematical Institute at the University of Oxford and co-author, said: ?It has been fascinating to use machine learning to discover new and unexpected connections between different areas of mathematics. I believe that the work that we have done in Oxford and in Sydney in collaboration with DeepMind demonstrates that machine learning can be a genuinely useful tool in mathematical research.?

Professor Geordie Williamson, Professor of Mathematics at the University of Sydney and director of the Sydney Mathematical Research Institute and co-author, said: ?AI is an extraordinary tool. This work is one of the first times it has demonstrated its usefulness for pure mathematicians, like me.

?Intuition can take us a long way, but AI can help us find connections the human mind might not always easily spot.?

We would love to thank the writer of this short article for this remarkable content

Machine learning helps mathematicians make new connections

[date_timestamp] => 1638479980 ) [5] => Array ( [title] => Toro show for half an hour, then red in Singo and Empoli comeback [link] => https://moustachebrothers.com/toro-show-for-half-an-hour-then-red-in-singo-and-empoli-comeback/ [dc] => Array ( [creator] => Debby Kent ) [pubdate] => Thu, 02 Dec 2021 20:26:20 +0000 [category] => MotoringcomebackEmpolihourRedSingoToro [guid] => https://moustachebrothers.com/?p=8670 [description] => The goals of Pobega and Pjaca in the first quarter of an hour are not enough for Juric: in 10 the grenades suffer the attacks of the Tuscans, who tear the tie with Romagnoli and La Mantia From our correspondent Mario Pagliara 2 December – TORINO It is the point of regrets, both for Toro ... Read more [content] => Array ( [encoded] =>

The goals of Pobega and Pjaca in the first quarter of an hour are not enough for Juric: in 10 the grenades suffer the attacks of the Tuscans, who tear the tie with Romagnoli and La Mantia

From our correspondent Mario Pagliara

It is the point of regrets, both for Toro and for Empoli. For the grenades because two to zero ahead of the quarter of an hour with Pobega and Pjaca did not manage to win on the evening when Torino celebrates its 115 years. Regrets also for Empoli, with the extra man for seventy minutes: he manages to go upstream with Romagnoli and La Mantia but does not find the knockout blow Game conditioned by the error of the referee Colombo and by Var Mazzoleni: the foul Singo at half an hour was not from direct red.

ONE TWO

?

The signature on the 115th anniversary of Toro is placed at the bottom by Tommaso Pobega. Because after just ten minutes the grenade midfielder presses Zurkowski very high with a devastating force: the result is a rebound that still favors Pobega, skilled in signing the grenade advantage. The evening of the grenade birthday seems to start immediately downhill for Juric’s team, lined up with its traditional 3-4-2-1: in the offensive trident Juric raises Marko Pjaca, missing from the first minute from 12 September against Salernitana. To make up the attacking department are Praet and Sanabria, the latter in place of the injured captain Belotti. All as expected also in Empoli, on the field with a 4-3-2-1 with Di Francesco, Henderson behind Pinamonti. The start of the Bull is overwhelming: if at the tenth minute he already puts his head forward, also at the fourth minute it is necessary to note the bursting descent of a Singo who makes 70 meters ball and chain before concluding (on the side). Pjaca is in the evening and you can guess it after eight minutes when an assist for Sanabria comes out of his shot dirty from Ricci’s back: the Paraguayan hits comfortable with his head but does not frame the goal. Once he takes the lead with Pobega (by the way, he’s on his third goal in the league), it’s time to enjoy the Pjaca-show: in the quarter of an hour, the Croatian seats two Tuscan defenders, before exploding a right perfect round the corner. After fifteen minutes of play Toro 2 Empoli 0. Third goal in Serie A also for Pjaca.

RED A SINGLE

?

If we want to find a fault in this first half of the grenade it is to have thought, probably, that he had already brought home the game too soon. And instead at half an hour comes the episode that reopens everything: Singo lands Di Francesco thrown at the goal. Referee Colombo (a ’90 class whistle, his first run in Serie A) rightly assigns the penalty and a yellow card. At the Var there is the more experienced Mazzoleni who calls him to the monitor, invoking an in-depth analysis to verify if there could be the extremes for a direct red (which is triggered in the case of a clear opportunity from the net). Colombo goes to the video and changes the card: from yellow to direct red. The second decision is wrong. At half an hour Toro therefore in ten men, and four minutes later on the developments of a corner Romagnoli catches the header that reopens the games. Taken the goal, Juric runs for cover: pulls out an excellent Pjaca on the bench, inserting Vojvoda on the right. In the final half, Toro still dances but Milinkovic is careful on Pinamonti (40 ‘).

2-2 LA MANTIA

?

When the recovery begins, a shiver immediately runs on Toro’s back: after just fifty seconds a cross from Di Francesco hits Bremer’s back with the ball caroming Milinkovic’s crossbar. The game rises in tone, becomes nasty: there are different entries of the Empoli defenders at the limits of the regulation, with the young referee Colombo who does not give the feeling of knowing how to control the spirits on the pitch. Aina, Juric and Marchizza pay the price: warned. Despite the man in minus the grenades try to withstand the impact, but slowly the petrol runs out and no supplies arrive from the bench. Yet at 21 ‘Toro devours the blow of the knockout: Bremer opposes Luperto in front of his own area, runs away using the open field and shoots a diagonal that almost ends at the corner. The law of retaliation is relentless: six minutes later, from a perfect cross by Luperto, the head of La Mantia arrives to place the 2-2. Late, Juric makes the changes: Rincon for Praet, Zaza in place of Sanabria. In the end, the Bull suffers but manages to bring home a precious point, albeit full of regrets.

We want to say thanks to the author of this post for this remarkable content

Toro show for half an hour, then red in Singo and Empoli comeback

) [summary] => The goals of Pobega and Pjaca in the first quarter of an hour are not enough for Juric: in 10 the grenades suffer the attacks of the Tuscans, who tear the tie with Romagnoli and La Mantia From our correspondent Mario Pagliara 2 December – TORINO It is the point of regrets, both for Toro ... Read more [atom_content] =>

The goals of Pobega and Pjaca in the first quarter of an hour are not enough for Juric: in 10 the grenades suffer the attacks of the Tuscans, who tear the tie with Romagnoli and La Mantia

From our correspondent Mario Pagliara

It is the point of regrets, both for Toro and for Empoli. For the grenades because two to zero ahead of the quarter of an hour with Pobega and Pjaca did not manage to win on the evening when Torino celebrates its 115 years. Regrets also for Empoli, with the extra man for seventy minutes: he manages to go upstream with Romagnoli and La Mantia but does not find the knockout blow Game conditioned by the error of the referee Colombo and by Var Mazzoleni: the foul Singo at half an hour was not from direct red.

ONE TWO

?

The signature on the 115th anniversary of Toro is placed at the bottom by Tommaso Pobega. Because after just ten minutes the grenade midfielder presses Zurkowski very high with a devastating force: the result is a rebound that still favors Pobega, skilled in signing the grenade advantage. The evening of the grenade birthday seems to start immediately downhill for Juric’s team, lined up with its traditional 3-4-2-1: in the offensive trident Juric raises Marko Pjaca, missing from the first minute from 12 September against Salernitana. To make up the attacking department are Praet and Sanabria, the latter in place of the injured captain Belotti. All as expected also in Empoli, on the field with a 4-3-2-1 with Di Francesco, Henderson behind Pinamonti. The start of the Bull is overwhelming: if at the tenth minute he already puts his head forward, also at the fourth minute it is necessary to note the bursting descent of a Singo who makes 70 meters ball and chain before concluding (on the side). Pjaca is in the evening and you can guess it after eight minutes when an assist for Sanabria comes out of his shot dirty from Ricci’s back: the Paraguayan hits comfortable with his head but does not frame the goal. Once he takes the lead with Pobega (by the way, he’s on his third goal in the league), it’s time to enjoy the Pjaca-show: in the quarter of an hour, the Croatian seats two Tuscan defenders, before exploding a right perfect round the corner. After fifteen minutes of play Toro 2 Empoli 0. Third goal in Serie A also for Pjaca.

RED A SINGLE

?

If we want to find a fault in this first half of the grenade it is to have thought, probably, that he had already brought home the game too soon. And instead at half an hour comes the episode that reopens everything: Singo lands Di Francesco thrown at the goal. Referee Colombo (a ’90 class whistle, his first run in Serie A) rightly assigns the penalty and a yellow card. At the Var there is the more experienced Mazzoleni who calls him to the monitor, invoking an in-depth analysis to verify if there could be the extremes for a direct red (which is triggered in the case of a clear opportunity from the net). Colombo goes to the video and changes the card: from yellow to direct red. The second decision is wrong. At half an hour Toro therefore in ten men, and four minutes later on the developments of a corner Romagnoli catches the header that reopens the games. Taken the goal, Juric runs for cover: pulls out an excellent Pjaca on the bench, inserting Vojvoda on the right. In the final half, Toro still dances but Milinkovic is careful on Pinamonti (40 ‘).

2-2 LA MANTIA

?

When the recovery begins, a shiver immediately runs on Toro’s back: after just fifty seconds a cross from Di Francesco hits Bremer’s back with the ball caroming Milinkovic’s crossbar. The game rises in tone, becomes nasty: there are different entries of the Empoli defenders at the limits of the regulation, with the young referee Colombo who does not give the feeling of knowing how to control the spirits on the pitch. Aina, Juric and Marchizza pay the price: warned. Despite the man in minus the grenades try to withstand the impact, but slowly the petrol runs out and no supplies arrive from the bench. Yet at 21 ‘Toro devours the blow of the knockout: Bremer opposes Luperto in front of his own area, runs away using the open field and shoots a diagonal that almost ends at the corner. The law of retaliation is relentless: six minutes later, from a perfect cross by Luperto, the head of La Mantia arrives to place the 2-2. Late, Juric makes the changes: Rincon for Praet, Zaza in place of Sanabria. In the end, the Bull suffers but manages to bring home a precious point, albeit full of regrets.

We want to say thanks to the author of this post for this remarkable content

Toro show for half an hour, then red in Singo and Empoli comeback

[date_timestamp] => 1638476780 ) [6] => Array ( [title] => Blue, first step towards the World Cup: overwhelmed the Scots [link] => https://moustachebrothers.com/blue-first-step-towards-the-world-cup-overwhelmed-the-scots/ [dc] => Array ( [creator] => Lance Kind ) [pubdate] => Thu, 02 Dec 2021 20:19:24 +0000 [category] => RugbyblueCupoverwhelmedScotsstep [guid] => https://moustachebrothers.com/?p=8664 [description] => In Parma it was easy for Italy to 38-13 (6 tries to one), with a match already scored at half-time. On Sunday the match against Ireland again at Lanfranchi, sensationally defeated by Spain (8-7) The first, important step is taken. In Parma, in the opening match of next year’s World Cup qualifying tournament in New ... Read more [content] => Array ( [encoded] =>

In Parma it was easy for Italy to 38-13 (6 tries to one), with a match already scored at half-time. On Sunday the match against Ireland again at Lanfranchi, sensationally defeated by Spain (8-7)

The first, important step is taken. In Parma, in the opening match of next year’s World Cup qualifying tournament in New Zealand, Italy got rid of Scotland rather easily (38-13, 6 goals to one), also conquering the offensive bonus point already at the end of the first half with four goals that are anything but trivial in their construction. The Azzurre made it clear from kick-off that the intention was to command the match. On the first ball of the match, in fact, Giada Franco went to contend for the oval in the ruck and snatched a free kick that led Italy to attack in the 22 opponents. From the lineout the maul brought the oval close to the goal area for Franco’s winning pick and go.

reaction

?

Scotland tried to react by finding a kick under the posts that Nelson converted in the 7th minute. It was the only visit to the 22 that the Italian defense granted to the Scots who, thanks to the blue pressure but also the heat of the Parmesan afternoon (31st at kick-off), then collapsed in the second half of the first fraction. Italy extended in the 21st minute with a throw-in play in the middle of the pitch: an open oval on the right wing for the first thrust of Ostuni Minozzi who then found the winning support of Maria Magatti. Four minutes and this time from a touch-off stolen by Bettoni a counterattack started in which Arrighetti and Gai showed that Italy has quality even in the hands of the forwards to send Sara Barattin into the goalposts. That Scotland no longer had any was also demonstrated by the choice, at 19-3, to place from halfway with Nelson instead of trying to look for the lineout. Italy thus took advantage of its superiority further by finding the bonus goal with another beautiful play by Veronica Madia for Ilaria Arrighetti’s winning running line.

rest

?

A few too many fouls at the start of the second half allowed Scotland to play for a long time in the attacking half. A sterile territorial supremacy, because the Italian defense proves to be very present at the meeting points to recover the oval. In the meantime, there was room for the debut of the young hooker Vittoria Vecchini just before the fifth Italian try. The action still comes from a recovery ball with the sprint to Magatti’s wing, the support to the center of Barattin and the winning assist for the sprint by Michela Sillari The sixth goal is a Madia soccer for the dive into the goal of the captain Manuela Furlan. Only 10 minutes from the end, with Italy outnumbered by the yellow in Sgorbini, Scotland managed to cross the blue goal line with Lloyd. In the final 5 minutes first cap also for the right prop Sara Seye. Having overcome the first obstacle, now immediately head to the second: Sunday afternoon at 3 pm, again at Lanfranchi di Parma, the match against Ireland which in the second match of the day lost, in a sensational way, against Spain (8-7).

We wish to say thanks to the writer of this article for this awesome material

Blue, first step towards the World Cup: overwhelmed the Scots

) [summary] => In Parma it was easy for Italy to 38-13 (6 tries to one), with a match already scored at half-time. On Sunday the match against Ireland again at Lanfranchi, sensationally defeated by Spain (8-7) The first, important step is taken. In Parma, in the opening match of next year’s World Cup qualifying tournament in New ... Read more [atom_content] =>

In Parma it was easy for Italy to 38-13 (6 tries to one), with a match already scored at half-time. On Sunday the match against Ireland again at Lanfranchi, sensationally defeated by Spain (8-7)

The first, important step is taken. In Parma, in the opening match of next year’s World Cup qualifying tournament in New Zealand, Italy got rid of Scotland rather easily (38-13, 6 goals to one), also conquering the offensive bonus point already at the end of the first half with four goals that are anything but trivial in their construction. The Azzurre made it clear from kick-off that the intention was to command the match. On the first ball of the match, in fact, Giada Franco went to contend for the oval in the ruck and snatched a free kick that led Italy to attack in the 22 opponents. From the lineout the maul brought the oval close to the goal area for Franco’s winning pick and go.

reaction

?

Scotland tried to react by finding a kick under the posts that Nelson converted in the 7th minute. It was the only visit to the 22 that the Italian defense granted to the Scots who, thanks to the blue pressure but also the heat of the Parmesan afternoon (31st at kick-off), then collapsed in the second half of the first fraction. Italy extended in the 21st minute with a throw-in play in the middle of the pitch: an open oval on the right wing for the first thrust of Ostuni Minozzi who then found the winning support of Maria Magatti. Four minutes and this time from a touch-off stolen by Bettoni a counterattack started in which Arrighetti and Gai showed that Italy has quality even in the hands of the forwards to send Sara Barattin into the goalposts. That Scotland no longer had any was also demonstrated by the choice, at 19-3, to place from halfway with Nelson instead of trying to look for the lineout. Italy thus took advantage of its superiority further by finding the bonus goal with another beautiful play by Veronica Madia for Ilaria Arrighetti’s winning running line.

rest

?

A few too many fouls at the start of the second half allowed Scotland to play for a long time in the attacking half. A sterile territorial supremacy, because the Italian defense proves to be very present at the meeting points to recover the oval. In the meantime, there was room for the debut of the young hooker Vittoria Vecchini just before the fifth Italian try. The action still comes from a recovery ball with the sprint to Magatti’s wing, the support to the center of Barattin and the winning assist for the sprint by Michela Sillari The sixth goal is a Madia soccer for the dive into the goal of the captain Manuela Furlan. Only 10 minutes from the end, with Italy outnumbered by the yellow in Sgorbini, Scotland managed to cross the blue goal line with Lloyd. In the final 5 minutes first cap also for the right prop Sara Seye. Having overcome the first obstacle, now immediately head to the second: Sunday afternoon at 3 pm, again at Lanfranchi di Parma, the match against Ireland which in the second match of the day lost, in a sensational way, against Spain (8-7).

We wish to say thanks to the writer of this article for this awesome material

Blue, first step towards the World Cup: overwhelmed the Scots

[date_timestamp] => 1638476364 ) [7] => Array ( [title] => One of the most important Final Fantasy, and its role in Endwalker [link] => https://moustachebrothers.com/one-of-the-most-important-final-fantasy-and-its-role-in-endwalker/ [dc] => Array ( [creator] => Toby Peters ) [pubdate] => Thu, 02 Dec 2021 20:11:41 +0000 [category] => SportEndwalkerFantasyfinalrole [guid] => https://moustachebrothers.com/?p=8658 [description] => Final Fantasy IV will play a fundamental role in the story of Final Fantasy XIV, not only in secondary aspects such as mounts and minions. Here because. To prepare you worthily for the new chapter in the history of Final Fantasy XIV, it’s worth taking a look at Endwalker’s references to Final Fantasy IV, which, ... Read more [content] => Array ( [encoded] =>

Final Fantasy IV will play a fundamental role in the story of Final Fantasy XIV, not only in secondary aspects such as mounts and minions. Here because.

To prepare you worthily for the new chapter in the history of Final Fantasy XIV, it’s worth taking a look at Endwalker’s references to Final Fantasy IV, which, you’ll soon find out, go far beyond mounts and minions. A few days after the release of Final Fantasy XIV: Endwalker, it’s time to get ready for all the news coming: finish the main story quests and level up your side jobs, first of all. Not only that, though: it’s also time to fortify your knowledge of FFIV, so that you can deepen the story by grasping every aspect. To help you on this journey, here’s an explanation of the more explicit elements taken from Final Fantasy IV, as well as the story passages the two games have in common.

Add 4 to 14 –

Although Endwalker isn’t out yet, you can see FFIV influences all over the place. Towards the end of Shadowbringers, the previous expansion, the development team began this process of implementing Lunar Bahamut. Fandaniel, an ascian who wants to kill lots of people and destroy the world of Eorzea, summons an altered version of many primals, including il Lunar Bahamut. This creature is only an optional boss in FFIV, but the Lunar Bahamut has created a connection between that game and FFXIV, at the same time indicating that the Moon will play an important role in the story from here on out.

The connection between the two games was confirmed at the FFXIV Fan Festival, when the trailer for Endwalker was unveiled. Square Enix also announced new items for the Mogstation shop: three new minions and a new mount, all originally part of the main FFIV story.

The three minions are based on the main cast of characters from FFIV. You can buy Rosa for your collection: she is a childhood friend of the main character, Cecil. There’s also Edge, an edgy ninja and prince of Eblan. The third character you can have with you is a miniaturized version of Rydia. As a young man, Rydia met Cecil after he and his friend Kain attacked her village and killed her mother, defeating the eidolon she had summoned. Eventually, she finds herself following Cecil and her party. During their journey, however, she falls into the ocean and is taken from Leviathan to Feymarch, where time passes faster. When she reunites with Cecil and the others, she is already a young woman and a powerful summoner.

As if that weren’t enough, having these three important characters reunited with the Warrior of Light in Eorzea, players can also fly in their next adventure in full FFIV style. The Lunar Whale eight-player mount It may attract a lot of attention due to its size and price, but it’s also an integral part of the FFIV story. Once they discover the truth about what is happening, the characters must leave for the moon. To do this, they have to use a strange whale-shaped spaceship.

Other FFIV-inspired elements were teased in the latest Live Letter, which unveiled the tomestone gear sets. In FFXIV, these sets can be bought using tomestone, a specific currency that is acquired by completing various tasks. They are an important part of a player’s routine, as they usually need to be used to get the best pieces of gear that can be obtained with a new patch. New sets have been introduced at the beginning and during the life cycle of the new expansions, and that won’t change with Endwalker. Some of the new pieces of equipment have been shown since producer e director Naoki Yoshida, and among them are some based on the main characters of FFIV. For example, tank players will be able to purchase Cecil’s armor, ninjas will be able to use Edge’s, and Rydia’s outfit will likely be suited to summoners. The connections go beyond the aesthetic aspects, however. Cecil’s story is the heart of Endwalker.

The end of a journey –

Ever since it came out, Final Fantasy XIV has always been a playground for fans of the series. There have been tons of crossovers with other titles in the saga but choosing FFIV for this specific moment in the game’s history it’s really symbolic by the development team.

SS 04

Upon the announcement of Endwalker, Naoki Yoshida explained that it would be the last expansion that would cover the story that began with A Realm Reborn. His statement was misunderstood and many thought it would be the end of the game, but this chapter is meant only to close the story of the conflict between the two entities involved in the main narrative so far: Hydaelyn e Zodiark. After that, the game will take new directions, immersing fans in different stories.

New stories, changes, perspectives and the idea of ??transition are key parts of both FFIV and FFXIV. In each expansion of FFXIV, the protagonist acquires new jobs (the classes of this MMO). In Shadowbringers, you start out as a knight. In the Endwalker trailer, the Warrior of Light appears, walking on the moon and wearing the glittering metal armor of a paladin complete with a sword and shield. This same change happens to the protagonist of FFIV, Cecil. At the beginning of the game, Cecil is a dark knight who works as the captain of an airship called Red Wings. During his journey, after defeating his demons, he transforms into a paladin.

Final Fantasy XIV influenced by FFIV: how and why

The transformation Cecil arrives when he discovers that his father was a Lunarian, a member of the advanced civilization hibernating on the Moon. Changing his job (i.e. class) symbolizes his inner transformation as a person. This gives players a lot to think about what we might see in Endwalker. In Shadowbringers, it is shown that even Hydaelyn is not purity embodied as previously thought and that too much light can hurt a world that should aim for balance. The main story implies that the main character’s spirit may have come from the original Ascians, another little piece of information that ends up relativizing the world as known until then. Will players uncover the truth behind the Warrior of Light’s origins? Is something fundamental about to change in the protagonist?

It’s unclear if the new expansion will delve into these themes, but it would make sense if the story pointed to reflect that of FFIV. The expectations are huge for Endwalker, considering the position that Final Fantasy XIV occupies today – that is, that of one of the best Final Fantasy ever made. Whether or not it respects these expectations, it is not yet known. But, considering what has already been shown to the public and all the possibilities that FFIV opens up to the Endwalker narrative, it is clear how much the development team is striving to create a memorable experience for fans of the saga.

Written by Paulo Kawanishi for GLHF

We wish to say thanks to the author of this short article for this incredible content

One of the most important Final Fantasy, and its role in Endwalker

) [summary] => Final Fantasy IV will play a fundamental role in the story of Final Fantasy XIV, not only in secondary aspects such as mounts and minions. Here because. To prepare you worthily for the new chapter in the history of Final Fantasy XIV, it’s worth taking a look at Endwalker’s references to Final Fantasy IV, which, ... Read more [atom_content] =>

Final Fantasy IV will play a fundamental role in the story of Final Fantasy XIV, not only in secondary aspects such as mounts and minions. Here because.

To prepare you worthily for the new chapter in the history of Final Fantasy XIV, it’s worth taking a look at Endwalker’s references to Final Fantasy IV, which, you’ll soon find out, go far beyond mounts and minions. A few days after the release of Final Fantasy XIV: Endwalker, it’s time to get ready for all the news coming: finish the main story quests and level up your side jobs, first of all. Not only that, though: it’s also time to fortify your knowledge of FFIV, so that you can deepen the story by grasping every aspect. To help you on this journey, here’s an explanation of the more explicit elements taken from Final Fantasy IV, as well as the story passages the two games have in common.

Add 4 to 14 –

Although Endwalker isn’t out yet, you can see FFIV influences all over the place. Towards the end of Shadowbringers, the previous expansion, the development team began this process of implementing Lunar Bahamut. Fandaniel, an ascian who wants to kill lots of people and destroy the world of Eorzea, summons an altered version of many primals, including il Lunar Bahamut. This creature is only an optional boss in FFIV, but the Lunar Bahamut has created a connection between that game and FFXIV, at the same time indicating that the Moon will play an important role in the story from here on out.

The connection between the two games was confirmed at the FFXIV Fan Festival, when the trailer for Endwalker was unveiled. Square Enix also announced new items for the Mogstation shop: three new minions and a new mount, all originally part of the main FFIV story.

The three minions are based on the main cast of characters from FFIV. You can buy Rosa for your collection: she is a childhood friend of the main character, Cecil. There’s also Edge, an edgy ninja and prince of Eblan. The third character you can have with you is a miniaturized version of Rydia. As a young man, Rydia met Cecil after he and his friend Kain attacked her village and killed her mother, defeating the eidolon she had summoned. Eventually, she finds herself following Cecil and her party. During their journey, however, she falls into the ocean and is taken from Leviathan to Feymarch, where time passes faster. When she reunites with Cecil and the others, she is already a young woman and a powerful summoner.

As if that weren’t enough, having these three important characters reunited with the Warrior of Light in Eorzea, players can also fly in their next adventure in full FFIV style. The Lunar Whale eight-player mount It may attract a lot of attention due to its size and price, but it’s also an integral part of the FFIV story. Once they discover the truth about what is happening, the characters must leave for the moon. To do this, they have to use a strange whale-shaped spaceship.

Other FFIV-inspired elements were teased in the latest Live Letter, which unveiled the tomestone gear sets. In FFXIV, these sets can be bought using tomestone, a specific currency that is acquired by completing various tasks. They are an important part of a player’s routine, as they usually need to be used to get the best pieces of gear that can be obtained with a new patch. New sets have been introduced at the beginning and during the life cycle of the new expansions, and that won’t change with Endwalker. Some of the new pieces of equipment have been shown since producer e director Naoki Yoshida, and among them are some based on the main characters of FFIV. For example, tank players will be able to purchase Cecil’s armor, ninjas will be able to use Edge’s, and Rydia’s outfit will likely be suited to summoners. The connections go beyond the aesthetic aspects, however. Cecil’s story is the heart of Endwalker.

The end of a journey –

Ever since it came out, Final Fantasy XIV has always been a playground for fans of the series. There have been tons of crossovers with other titles in the saga but choosing FFIV for this specific moment in the game’s history it’s really symbolic by the development team.

SS 04

Upon the announcement of Endwalker, Naoki Yoshida explained that it would be the last expansion that would cover the story that began with A Realm Reborn. His statement was misunderstood and many thought it would be the end of the game, but this chapter is meant only to close the story of the conflict between the two entities involved in the main narrative so far: Hydaelyn e Zodiark. After that, the game will take new directions, immersing fans in different stories.

New stories, changes, perspectives and the idea of ??transition are key parts of both FFIV and FFXIV. In each expansion of FFXIV, the protagonist acquires new jobs (the classes of this MMO). In Shadowbringers, you start out as a knight. In the Endwalker trailer, the Warrior of Light appears, walking on the moon and wearing the glittering metal armor of a paladin complete with a sword and shield. This same change happens to the protagonist of FFIV, Cecil. At the beginning of the game, Cecil is a dark knight who works as the captain of an airship called Red Wings. During his journey, after defeating his demons, he transforms into a paladin.

Final Fantasy XIV influenced by FFIV: how and why

The transformation Cecil arrives when he discovers that his father was a Lunarian, a member of the advanced civilization hibernating on the Moon. Changing his job (i.e. class) symbolizes his inner transformation as a person. This gives players a lot to think about what we might see in Endwalker. In Shadowbringers, it is shown that even Hydaelyn is not purity embodied as previously thought and that too much light can hurt a world that should aim for balance. The main story implies that the main character’s spirit may have come from the original Ascians, another little piece of information that ends up relativizing the world as known until then. Will players uncover the truth behind the Warrior of Light’s origins? Is something fundamental about to change in the protagonist?

It’s unclear if the new expansion will delve into these themes, but it would make sense if the story pointed to reflect that of FFIV. The expectations are huge for Endwalker, considering the position that Final Fantasy XIV occupies today – that is, that of one of the best Final Fantasy ever made. Whether or not it respects these expectations, it is not yet known. But, considering what has already been shown to the public and all the possibilities that FFIV opens up to the Endwalker narrative, it is clear how much the development team is striving to create a memorable experience for fans of the saga.

Written by Paulo Kawanishi for GLHF

We wish to say thanks to the author of this short article for this incredible content

One of the most important Final Fantasy, and its role in Endwalker

[date_timestamp] => 1638475901 ) [8] => Array ( [title] => Targeting the brain?s immune cells may help prevent or treat Alzheimer?s disease [link] => https://moustachebrothers.com/targeting-the-brains-immune-cells-may-help-prevent-or-treat-alzheimers-disease/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 02 Dec 2021 20:02:24 +0000 [category] => Health And ScienceAlzheimersbrainscellsdiseaseimmunepreventTargetingtreat [guid] => https://moustachebrothers.com/?p=8653 [description] => Journal Reference: Faten A. Sayed, Lay Kodama, Li Fan, Gillian K. Carling, Joe C. Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew Brendel, Maria Telpoukhovskaia, Tara E. Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Faten A. Sayed, Lay Kodama, Li Fan, Gillian K. Carling, Joe C. Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew Brendel, Maria Telpoukhovskaia, Tara E. Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, Yue Qiu, Zuolin Cheng, Guoqiang Yu, John Hardy, Giovanni Coppola, Fei Wang, Michael A. DeTure, Bin Zhang, Lei Xie, John Q. Trajnowski, Virginia M. Y. Lee, Shiaoching Gong, Subhash C. Sinha, Dennis W. Dickson, Wenjie Luo, Li Gan. AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science Translational Medicine, 2021; 13 (622) DOI: 10.1126/scitranslmed.abe3947

The study, published Dec. 1 in Science Translational Medicine, focused on microglia, immune cells of the central nervous system that are the first to respond when something goes wrong in the brain. Studies have identified many genetic variants linked to Alzheimer?s disease that are highly expressed in microglia, providing compelling evidence that alterations within these cells may play a role in the disease?s onset and progression.

?Microglia are guardians of the brain under healthy conditions, but can turn detrimental in disease conditions. Our goal is to identify how they become toxic and contribute to Alzheimer?s disease pathogenesis and whether we can identify immune modulators to reverse the toxicity without diminishing their normal protective function,? said senior author Dr. Li Gan, director of the Helen and Robert Appel Alzheimer?s Disease Research Institute and the Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine.

Alzheimer?s disease is the most prevalent neurodegenerative disease in ageing, affecting approximately 46 million people worldwide. Theories point to a number of potential causes, including age-related changes in the brain, along with genetic, environmental, and lifestyle factors. These lead to the accumulation of toxic proteins in the brain ? and according to recent evidence, immune system changes ? that result in loss of neurons and their connections.

To examine how the brain?s immune cells may contribute to Alzheimer?s disease, Dr. Gan and her colleagues first established the molecule fingerprint of individual microglia in the brains of patients with Alzheimer?s disease who carry a mutation in the TREM2 gene that markedly elevates individual?s risk for developing Alzheimer?s disease. TREM2 is a receptor mainly expressed by microglia in the brain, and among other functions, it signals through an enzyme named AKT to modulate inflammation and metabolism.

The team then established a mouse model by combining two strains; one that carries the AD-linked mutation in the TREM2 gene and another that exhibits Tau aggregates, one of the major pathological hallmarks in Alzheimer brains. Both patients and mice with the mutation demonstrated memory-related deficits, and their microglia expressed high levels of inflammatory molecules and exhibited an overactive AKT signaling pathway. In the mice, inhibiting AKT with a drug called MK-2206 reversed the inflammatory properties of microglia and protected against synaptic toxicity ? a type of damage to the brain?s neurons that is a hallmark of Alzheimer?s disease.

Importantly, because AKT signaling also contributes to the pathogenesis of many types of cancer, MK-2206 is currently being evaluated in multiple cancer clinical trials. Therefore, the safety of the drug is already under investigation.

?We identified a small molecule compound that has been tested in patients with cancer, readily enters the brain, potently modulates the brain?s immune responses, and protects against synaptic loss in animal models of Alzheimer?s disease,? Dr. Gan said. ?Our findings support further study of this compound as a potential therapy for Alzheimer?s disease.?

Dr. Li Gan is a co-founder with equity and consultant for Aeton Therapeutics, Inc.

We would like to thank the writer of this article for this amazing content

Targeting the brain?s immune cells may help prevent or treat Alzheimer?s disease

) [summary] => Journal Reference: Faten A. Sayed, Lay Kodama, Li Fan, Gillian K. Carling, Joe C. Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew Brendel, Maria Telpoukhovskaia, Tara E. Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, ... Read more [atom_content] =>

Journal Reference:

  1. Faten A. Sayed, Lay Kodama, Li Fan, Gillian K. Carling, Joe C. Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew Brendel, Maria Telpoukhovskaia, Tara E. Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, Yue Qiu, Zuolin Cheng, Guoqiang Yu, John Hardy, Giovanni Coppola, Fei Wang, Michael A. DeTure, Bin Zhang, Lei Xie, John Q. Trajnowski, Virginia M. Y. Lee, Shiaoching Gong, Subhash C. Sinha, Dennis W. Dickson, Wenjie Luo, Li Gan. AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science Translational Medicine, 2021; 13 (622) DOI: 10.1126/scitranslmed.abe3947

The study, published Dec. 1 in Science Translational Medicine, focused on microglia, immune cells of the central nervous system that are the first to respond when something goes wrong in the brain. Studies have identified many genetic variants linked to Alzheimer?s disease that are highly expressed in microglia, providing compelling evidence that alterations within these cells may play a role in the disease?s onset and progression.

?Microglia are guardians of the brain under healthy conditions, but can turn detrimental in disease conditions. Our goal is to identify how they become toxic and contribute to Alzheimer?s disease pathogenesis and whether we can identify immune modulators to reverse the toxicity without diminishing their normal protective function,? said senior author Dr. Li Gan, director of the Helen and Robert Appel Alzheimer?s Disease Research Institute and the Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine.

Alzheimer?s disease is the most prevalent neurodegenerative disease in ageing, affecting approximately 46 million people worldwide. Theories point to a number of potential causes, including age-related changes in the brain, along with genetic, environmental, and lifestyle factors. These lead to the accumulation of toxic proteins in the brain ? and according to recent evidence, immune system changes ? that result in loss of neurons and their connections.

To examine how the brain?s immune cells may contribute to Alzheimer?s disease, Dr. Gan and her colleagues first established the molecule fingerprint of individual microglia in the brains of patients with Alzheimer?s disease who carry a mutation in the TREM2 gene that markedly elevates individual?s risk for developing Alzheimer?s disease. TREM2 is a receptor mainly expressed by microglia in the brain, and among other functions, it signals through an enzyme named AKT to modulate inflammation and metabolism.

The team then established a mouse model by combining two strains; one that carries the AD-linked mutation in the TREM2 gene and another that exhibits Tau aggregates, one of the major pathological hallmarks in Alzheimer brains. Both patients and mice with the mutation demonstrated memory-related deficits, and their microglia expressed high levels of inflammatory molecules and exhibited an overactive AKT signaling pathway. In the mice, inhibiting AKT with a drug called MK-2206 reversed the inflammatory properties of microglia and protected against synaptic toxicity ? a type of damage to the brain?s neurons that is a hallmark of Alzheimer?s disease.

Importantly, because AKT signaling also contributes to the pathogenesis of many types of cancer, MK-2206 is currently being evaluated in multiple cancer clinical trials. Therefore, the safety of the drug is already under investigation.

?We identified a small molecule compound that has been tested in patients with cancer, readily enters the brain, potently modulates the brain?s immune responses, and protects against synaptic loss in animal models of Alzheimer?s disease,? Dr. Gan said. ?Our findings support further study of this compound as a potential therapy for Alzheimer?s disease.?

Dr. Li Gan is a co-founder with equity and consultant for Aeton Therapeutics, Inc.

We would like to thank the writer of this article for this amazing content

Targeting the brain?s immune cells may help prevent or treat Alzheimer?s disease

[date_timestamp] => 1638475344 ) [9] => Array ( [title] => Bottas? nightmare: ?In 2014 obsessed with weight: I was close to leaving F1? [link] => https://moustachebrothers.com/bottas-nightmare-in-2014-obsessed-with-weight-i-was-close-to-leaving-f1/ [dc] => Array ( [creator] => David Lonit ) [pubdate] => Thu, 02 Dec 2021 19:25:30 +0000 [category] => Formula 1Bottascloseleavingnightmareobsessedweight [guid] => https://moustachebrothers.com/?p=8647 [description] => The Finn from Mercedes on a podcast: ?I had become a ghost, I was obsessed with losing weight and I lost control. My ex-wife once wished me ‘good flight’ and I told her I didn’t care if the plane crashed. I was reborn thanks to a psychologist “ Racing in Formula 1? It is not ... Read more [content] => Array ( [encoded] =>

The Finn from Mercedes on a podcast: ?I had become a ghost, I was obsessed with losing weight and I lost control. My ex-wife once wished me ‘good flight’ and I told her I didn’t care if the plane crashed. I was reborn thanks to a psychologist “

Racing in Formula 1? It is not always a virtue. There are also the hard moments, in which the results do not arrive despite the efforts in training, on the simulator and on the track. Negative periods in a driver’s life, which can sometimes be detrimental to their physical and mental well-being. As Valtteri Bottas told the podcast “Direct talk about me”, with words then taken from the Finnish site ‘Iltalehti’: it all started from the complex of losing weight in 2014, the hardest year of his life, up to the thought of wanting say goodbye to the races in the Circus. Before the help of a psychologist gave him back that energy lost among negative thoughts.

To lose control

?

“I had to take a plane and my ex-wife (swimmer Emilia Pikkarainen, ed) wished me the flight went well. I replied by saying that I didn’t care if the plane crashed: in that case I would simply be dead – Bottas’ shocking words on the podcast -. These are the kind of thoughts I started having, as if nothing mattered any more. ” 2014 was a year to forget for the Finn, who at the time took fourth place in the drivers’ classification with Williams: ?I suffered from a serious state of fatigue, purely for my stubbornness – he added -. Then I had to reduce my weight to a minimum and I completely lost control ?.

The arrival of physical problems

?

Each extra kilo, in fact, means slowing down your car more on the track. Losing mass, for Bottas, had thus become an obsession: ?I had to weigh myself every morning and evening and the weight was always less – he continues on the podcast -. I was obsessed and obsessed, sometimes I completed a running exercise twice: once with my coach, the other alone without being seen. I thought it would do me good, but in the long run it obviously didn’t ?. So much so that physical problems arrived: ?I got tired very easily and couldn’t sleep – he says -, every night I woke up at 4 in the morning and couldn’t go back to sleep. This has affected my mental well-being: when you have removed every bit of your physical form, your mental side also empties ?.

The death of Bianchi and the psychologist

?

We couldn’t go on like this any longer, so much so that Emilia ?told me that I should have sought help, because I was no longer myself. I had become a kind of ghost ?. The fatal accident of Jules Bianchi in the 2014 Suzuka GP, the Frenchman from Marussia and product of the FDA who crashed into a racing crane and died in Nice the following year, deeply affected Bottas: “It was a hard blow – comments the driver who will be in Alfa Romeo from 2022 -, it took me two years to recover: I suffered from arrhythmia and sometimes I thought it was the end. I started to feel empty, my whole life was F1 and I didn’t like it at all. I thought about quitting ?. It was the help of a psychologist who gave him the strength to go forward: ?Something had to change, I took too many things too seriously – concludes Valtteri on the podcast -. I got help, I began to take everything more lightly and gradually I found my shape “.

We wish to give thanks to the writer of this short article for this amazing material

Bottas’ nightmare: “In 2014 obsessed with weight: I was close to leaving F1”

) [summary] => The Finn from Mercedes on a podcast: ?I had become a ghost, I was obsessed with losing weight and I lost control. My ex-wife once wished me ‘good flight’ and I told her I didn’t care if the plane crashed. I was reborn thanks to a psychologist “ Racing in Formula 1? It is not ... Read more [atom_content] =>

The Finn from Mercedes on a podcast: ?I had become a ghost, I was obsessed with losing weight and I lost control. My ex-wife once wished me ‘good flight’ and I told her I didn’t care if the plane crashed. I was reborn thanks to a psychologist “

Racing in Formula 1? It is not always a virtue. There are also the hard moments, in which the results do not arrive despite the efforts in training, on the simulator and on the track. Negative periods in a driver’s life, which can sometimes be detrimental to their physical and mental well-being. As Valtteri Bottas told the podcast “Direct talk about me”, with words then taken from the Finnish site ‘Iltalehti’: it all started from the complex of losing weight in 2014, the hardest year of his life, up to the thought of wanting say goodbye to the races in the Circus. Before the help of a psychologist gave him back that energy lost among negative thoughts.

To lose control

?

“I had to take a plane and my ex-wife (swimmer Emilia Pikkarainen, ed) wished me the flight went well. I replied by saying that I didn’t care if the plane crashed: in that case I would simply be dead – Bottas’ shocking words on the podcast -. These are the kind of thoughts I started having, as if nothing mattered any more. ” 2014 was a year to forget for the Finn, who at the time took fourth place in the drivers’ classification with Williams: ?I suffered from a serious state of fatigue, purely for my stubbornness – he added -. Then I had to reduce my weight to a minimum and I completely lost control ?.

The arrival of physical problems

?

Each extra kilo, in fact, means slowing down your car more on the track. Losing mass, for Bottas, had thus become an obsession: ?I had to weigh myself every morning and evening and the weight was always less – he continues on the podcast -. I was obsessed and obsessed, sometimes I completed a running exercise twice: once with my coach, the other alone without being seen. I thought it would do me good, but in the long run it obviously didn’t ?. So much so that physical problems arrived: ?I got tired very easily and couldn’t sleep – he says -, every night I woke up at 4 in the morning and couldn’t go back to sleep. This has affected my mental well-being: when you have removed every bit of your physical form, your mental side also empties ?.

The death of Bianchi and the psychologist

?

We couldn’t go on like this any longer, so much so that Emilia ?told me that I should have sought help, because I was no longer myself. I had become a kind of ghost ?. The fatal accident of Jules Bianchi in the 2014 Suzuka GP, the Frenchman from Marussia and product of the FDA who crashed into a racing crane and died in Nice the following year, deeply affected Bottas: “It was a hard blow – comments the driver who will be in Alfa Romeo from 2022 -, it took me two years to recover: I suffered from arrhythmia and sometimes I thought it was the end. I started to feel empty, my whole life was F1 and I didn’t like it at all. I thought about quitting ?. It was the help of a psychologist who gave him the strength to go forward: ?Something had to change, I took too many things too seriously – concludes Valtteri on the podcast -. I got help, I began to take everything more lightly and gradually I found my shape “.

We wish to give thanks to the writer of this short article for this amazing material

Bottas’ nightmare: “In 2014 obsessed with weight: I was close to leaving F1”

[date_timestamp] => 1638473130 ) ) [channel] => Array ( [title] => Moustache Brothers [link] => https://moustachebrothers.com [lastbuilddate] => Fri, 03 Dec 2021 00:26:00 +0000 [language] => en-US [sy] => Array ( [updateperiod] => hourly [updatefrequency] => 1 ) [generator] => https://wordpress.org/?v=5.8.2 [tagline] => ) [textinput] => Array ( ) [image] => Array ( ) [feed_type] => RSS [feed_version] => 2.0 [encoding] => ISO-8859-1 [_source_encoding] => [ERROR] => [WARNING] => [_CONTENT_CONSTRUCTS] => Array ( [0] => content [1] => summary [2] => info [3] => title [4] => tagline [5] => copyright ) [_KNOWN_ENCODINGS] => Array ( [0] => UTF-8 [1] => US-ASCII [2] => ISO-8859-1 ) [stack] => Array ( ) [inchannel] => [initem] => [incontent] => [intextinput] => [inimage] => [current_namespace] => [last_modified] => Fri, 03 Dec 2021 00:26:00 GMT [etag] => "e03e42bc1b7ceb90e8772d4660ba3c91-gzip" )